Cleveland Guardians vs Detroit Tigers Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Detroit Tigers

Date: Tuesday, September 16, 2025

Location: Comerica Park in Detroit, MI

TV: FanDuel Sports Network Detroit

Odds/Point Spread: Cleveland (+132) Detroit (-160)

Comerica Park is where the Detroit Tigers (85-65) will take on the Cleveland Guardians (78-71) on Tuesday. The moneyline on this game has the Guardians at +132 while the Tigers are opening at -160. The total comes in at 8.5. The pitchers expected to start will be Joey Cantillo and Casey Mize.

As a team, the Cleveland Guardians are notching 3.9 runs per outing, which ranks them 27th in the league. They have racked up 580 runs while holding a team on-base percentage of .296. The Guardians have tallied 216 doubles as a team and have hit 154 balls out of the park. They have 560 RBI's in addition to 1,095 hits so far this year, and their team batting average sits at .225. Cleveland is slugging .370 and have been rung up 1,224 times, while drawing a walk on 452 occasions.

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The Guardians are sitting with a team ERA of 3.80 for the year (6th in baseball), and the staff has struck out 1,236 hitters. Guardians pitchers have yielded 157 long balls and also 611 runs in total (8th in baseball). They have walked 497 opposing batters and their FIP comes in at 4.06 as a unit so far this year. Cleveland has surrendered 1,207 base hits (8.2 per 9 innings) in addition to 559 earned runs. Their K/BB ratio is 2.49 and their pitching staff sits with a WHIP of 1.29.

The Guardians relievers have a save percentage of 70.3% and have come into the game in 165 save situations. The relievers have inherited 188 runners for the season with 33.5% of them earned a run for their team. Guardians pitchers have come into the game with runners on 135 times in addition to having 174 appearances in high leverage situations. The Guardians have sent 486 relievers to the hill on the season. The relief pitchers have earned 98 holds for the season (5th in the league). They have compiled 45 saves for the year and have blown 19 of 64 save opportunities.

The Cincinnati Reds have a tally of 3,972 putouts this year, in addition to 1,231 assists and 90 errors. Their fielding percentage is currently at .983 which has them sitting 27th in baseball, and have accumulated 114 double plays. The Guardians have converted 69.7% of balls hit into play into outs in their 11,916 innings on the field, which has them ranked 19th in baseball.

Cantillo (7-7 career record) has earned a FIP of 3.82 while he has faced 504 hitters during his time in the major leagues. He has surrendered 102 hits (7.8 hits per 9 innings) and has 53 walks. His ERA is 3.88 (51 ER's allowed) and his WHIP is 1.310. Cantillo has pitched in 118 innings and has racked up 136 strikeouts during his pro baseball career.

The Tigers hold a team SLG% of .420 and they are earning 4.86 runs per outing (8th in the league). They have recorded 232 two-baggers, while walking 473 times and notching 729 runs. Detroit has hit 187 home runs this year and 695 RBIs. They have struck out on 1,323 occasions (6th in the league) and have tallied 1,259 base hits. The Detroit Tigers have a team OBP of .318 and a team batting average of .249 this season.

The Tigers have a WHIP of 1.238 and have a FIP of 4.07 as a team this year. Their K/BB ratio comes in at 8.50 (1,264 strikeouts against 442 free passes). They rank 12th in MLB as a pitching staff in total hits relinquished with 1,206. They have given up 174 home runs and they surrender 4.29 runs per 9 innings (12th in baseball). The Detroit pitching staff have conceded 634 runs for the year while holding a team ERA of 3.91 (578 earned runs yielded).

Detroit relievers have an inherited score percentage of 28.6% out of 231 inherited runners. Their relievers have stepped onto the mound 129 times in high leverage situations and on 163 occasions with runners on. Sitting with 132 save situations, the Tigers have tallied 70 holds in addition to 20 blown saves. They rank 9th in MLB with a save rate of 65.5%, and they have dispatched 461 bullpen pitchers to the mound so far this year. Detroit has called on bullpen pitchers to enter the contest in 58 save opportunities and they have come away with 38 saves.

In 11,979 innings played, the Tigers have earned a defensive efficiency of 70.3% (12th in baseball). The Detroit Tigers have gotten 123 double plays and have accounted for a fielding rate of .986 (16th in pro baseball). The Tigers have recorded 1,290 assists, 75 errors and have earned 3,993 putouts this season.

During his career, Mize has allowed 428 base knocks while he has totaled 344 punch outs in 422 innings pitched. He has given up a total of 197 earned runs while earning a WHIP of 1.291 and a FIP of 4.1. He has a K/BB ratio of 2.94 and he has gone up against 1,796 opposing hitters during his MLB career. Mize (23-24 career record) has a 4.20 earned run average while surrendering 9.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cleveland (+132)

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