Cleveland Guardians vs Detroit Tigers Prediction, 9/18/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Detroit Tigers

Date: Thursday, September 18, 2025

Location: Comerica Park in Detroit, MI

TV: FanDuel Sports Network Detroit

Odds/Point Spread: Cleveland (+120) Detroit (-144)

Comerica Park is where the Detroit Tigers (85-66) will attempt to beat the Cleveland Guardians (79-71) on Thursday. The moneyline on this matchup has the Guardians at +120 and the Tigers are sitting at -144. The over/under is 8. The men taking the mound will be Tanner Bibee and Tarik Skubal.

As a team, the Cleveland Guardians are compiling 3.9 runs per contest, which has them at 27th in the league. They have accounted for 587 runs while having a team on-base percentage of .296. The Guardians have recorded 221 doubles as a team and have knocked 155 baseballs out of the park. They have 567 runs batted in and 1,108 base knocks this year, while their team batting average is at .226. Cleveland is slugging .372 and have been called out on strikes 1,239 times, while being walked on 453 occasions.

Get all of our MLB Picks

The Guardians are sitting with a team ERA of 3.79 on the campaign (6th in baseball), and the staff has struck out 1,245 batters. Guardians pitchers have surrendered 160 home runs in addition to 616 total runs (7th in baseball). They have walked 500 opposing hitters and their FIP comes in at 4.08 as a unit for the year. Cleveland has yielded 1,215 hits (8.2 per 9 innings) and 562 earned runs. They have a K/BB ratio of 2.49 and the pitching staff holds a collective WHIP of 1.29.

The Guardians relief pitchers have a save rate of 69.2% and have entered the game in 170 save situations. The relief pitchers have inherited 191 runners for the year and 33.0% of them crossed the plate. Guardians bullpen pitchers have gone to the mound with opponents on base 139 times as well as having 177 appearances in high leverage situations. The Guardians have dispatched 492 relievers to the mound over the course of the season. The relievers have tallied 102 holds over the course of the season (3rd in the league). They have recorded 45 saves so far this year and have blown 20 of 65 save chances.

The Guardians have turned 69.7% of balls hit into play into outs out of 12,006 innings on the diamond, ranking them 19th in MLB. The Cincinnati Reds have earned 4,002 putouts this season, as well as 1,244 assists and 92 errors. Their fielding percentage sits at .983 which has them ranked 27th in MLB, and they have turned 114 double plays.

Bibee has taken the mound for 485 frames and has earned 477 punch outs in his pro baseball career. Bibee (32-23 career mark) is the owner of a FIP of 3.62 and he has faced 2,009 hitters in the majors. His ERA is 3.67 (198 earned runs allowed) and his WHIP is 1.179. He has given up 433 base hits (8.0 hits per 9 innings) with 139 walks.

The Detroit Tigers have a team on-base percentage of .318 as well as a team batting average of .249 so far this season. They have been called out on strikes on 1,332 occasions (6th in the league) and have 1,268 hits. Detroit has a total of 190 home runs so far this season and 700 runs batted in. The Tigers hold a team slugging percentage of .420 and they average 4.86 runs per game (9th in the league). They have hit 233 two-baggers, while walking 476 times as well as recording 734 runs.

The Tigers have a WHIP of 1.239 in addition to having a FIP of 4.06 as a unit over the course of the season. They currently have a strikeout to walk ratio of 8.60 (1,279 strikeouts against 443 bases on balls). They come in at 13th in MLB as a pitching staff in total hits surrendered with 1,219. They have conceded 175 homers and they allow 4.30 runs per 9 innings (12th in baseball). The Detroit pitching staff have yielded 641 runs this season while having an ERA of 3.92 (584 earned runs conceded).

Detroit has called on relievers to step onto the hill in 58 save opportunities and they have come away with 38 saves. They rank 9th in MLB holding a save rate of 65.5%, and they have sent 465 bullpen pitchers to the mound so far this season. Their relievers have come in 130 times in high leverage situations and on 166 occasions with base runners. Detroit bullpen pitchers hold an inherited score rate of 28.2% of 234 inherited base runners. With 132 save situations, the Tigers have accrued 70 holds in addition to 20 blown saves.

Out of their 12,069 innings on the diamond, the Tigers have a defensive efficiency of 70.2% (14th in professional baseball). The Detroit Tigers have gotten 123 double plays and have accounted for a fielding rate of .986 (16th in professional baseball). The Tigers have recorded 1,299 assists, 75 errors and have earned 4,023 putouts this year.

Thus far in his career, Skubal has surrendered 603 base hits while he has tallied 872 strikeouts in 754 innings pitched. He has allowed 260 earned runs while holding a WHIP of 1.021 and a FIP of 3.1. His K/BB ratio is 5.22 and he has faced 3,005 opposing hitters in his MLB career. Skubal (54-36 career win-loss mark) has earned a 3.10 earned run average and has allowed 7.2 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Detroit (-144)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here