Cleveland Guardians vs Minnesota Twins Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Minnesota Twins

Date: Wednesday, May 21, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Cleveland (+126) Minnesota (-152)

The Cleveland Guardians (25-21) are on their way to Target Field on Wednesday where they will try to beat the Minnesota Twins (26-21). The moneyline on this matchup has the Guardians at +126 while the Twins are opening at -152. The over/under is 8. The pitchers who are expected to start will be Tanner Bibee and Joe Ryan.

As a squad, the Cleveland Guardians are scoring 4.0 runs per outing, which puts them at 22nd in the league. They have racked up 182 runs scored while holding a team on-base percentage of .307. The Guardians have tallied 60 doubles as a unit and have hit 51 balls out of the park. They have accrued 171 runs batted in and 346 hits so far this season, and their team batting average is sitting at .233. Cleveland has a slugging rate of .380 and have struck out 360 times, while being walked on 149 occasions.

Get all of our MLB Betting Picks

Their strikeout to walk ratio is 2.35 and their pitching staff has a collective WHIP of 1.41. Guardians pitchers have conceded 53 home runs and also 202 runs (16th in the league). Cleveland has surrendered 403 base knocks (9.0 per 9 innings) as well as 186 earned runs. The Guardians have compiled a team earned run average of 4.14 for the season (19th in baseball), and the staff has struck out 392 batters. Their pitching staff has walked 167 hitters and their FIP is 4.18 as a squad so far this year.

Guardians pitchers have come into the game with runners on base 38 times in addition to having 44 appearances in high leverage situations. The bullpen have 38 holds on the year (2nd in baseball). The Guardians bullpen have a save percentage of 73.7% and stepped onto the hill in 57 save situations. They have earned 14 saves this year and have not converted 5 of 19 chances to get a save. The relief pitchers have inherited 55 base runners this season and 32.7% of them crossed home plate. The Guardians have dispatched 158 relief pitchers to the hill for the year.

The Guardians have converted 67.2% of balls in play into outs out of their 3,636 innings on the field, which has them ranked 27th in the majors. The Cincinnati Reds have earned a total of 1,212 putouts at this point in the season, as well as 346 assists and 30 errors. Their fielding percentage is at .981 which has them ranked 27th in professional baseball, and they have turned 37 double plays.

Bibee has thrown 366 frames and is sitting with 363 punch outs in his career. His ERA is 3.37 (137 earned runs allowed) and he has a career WHIP of 1.166. He has given up 321 hits (7.9 hits per 9 innings) and has 106 free passes. Bibee (25-16 career win-loss mark) is the owner of a FIP of 3.32 while he has gone up against 1,508 batters during his time in the major leagues.

The Twins hold a slugging percentage of .386 and they are scoring 4.13 runs per contest (19th in the league). They have recorded 78 doubles, while getting a free base 132 times and putting up 194 runs. Minnesota has compiled 45 home runs so far this year as well as 185 RBIs. They have been rung up on 385 occasions (18th in the league) and have 380 base knocks. The Minnesota Twins have accounted for an OBP of .310 in addition to a batting average of .242 over the course of the season.

The Twins have a WHIP of 1.139 in addition to having a FIP of 3.42 as a staff this year. They are currently ranked 5th in the league as a staff in total hits relinquished with 351. The Minnesota pitching staff have allowed 159 runs on the year while having a team ERA of 3.20 (146 earned runs allowed). Their strikeout to walk ratio sits at 9.20 (421 strikeouts vs 116 walks). They have surrendered 43 homers and they relinquish 3.49 runs per 9 innings (3rd in baseball).

Minnesota has called on bullpen pitchers to take the mound in 19 save opportunities and they have earned 12 saves. They are ranked 17th in baseball holding a save rate of 63.2%, and they have dispatched 161 relievers to the hill for the year. Their relief pitchers have stepped onto the mound 56 times in high leverage situations and on 33 occasions with runners on base. Minnesota relief pitchers hold an inherited score percentage of 34.0% out of their 47 inherited base runners. With 59 save situations, the Twins have compiled 38 holds in addition to 7 blown saves.

In 3,693 innings played, the Twins have accumulated a defensive efficiency of 70.3% (13th in the majors). The Minnesota Twins have gotten 25 double plays and have accounted for a fielding rate of .984 (22nd in baseball). The Twins have accrued 326 assists, 26 errors and have accumulated 1,231 putouts on the season.

During his pro baseball career, Ryan has conceded 431 base hits while tallying 588 punch outs in 522 innings. He has given up 219 earned runs while earning a WHIP of 1.046 and being the owner of a FIP of 3.7. His strikeout to walk ratio is 5.11 and he has gone up against 2,114 batters in his pro baseball career. Ryan (37-28 career record) is the owner of a 3.78 earned run average and has given up 7.4 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cleveland (+126)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here