Cleveland Guardians vs Minnesota Twins Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Minnesota Twins

Date: Friday, September 19, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Cleveland (-275) Minnesota (+220)

Target Field is the location where the Minnesota Twins (66-86) will meet the Cleveland Guardians (80-71) on Friday. The odds on this game have the Guardians at -275 and the Twins are opening at +220. The over/under comes in at 8. The starting pitchers are Logan Allen and Pablo Lopez.

As a team, the Cleveland Guardians are putting up 3.9 runs per outing, which has them sitting at 27th in the league. They have accumulated 591 runs scored and hold an OBP of .296. The Guardians have tallied 223 doubles as a team and have knocked 155 balls out of the stadium. They have amassed 571 runs batted in as well as 1,115 hits for the year, while their average at the plate is .225. Cleveland has a slugging % of .371 and have been called out on strikes 1,248 times, while taking a walk on 461 occasions.

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Their strikeout to walk ratio is 2.50 and their pitching staff has recorded a WHIP of 1.28. Guardians pitchers have given up 160 long balls and also 616 runs in total (6th in MLB). Cleveland has allowed 1,219 hits (8.2 per 9 innings) and 562 earned runs. The Guardians are sitting with a team earned run average of 3.77 so far this year (5th in baseball), and their staff has rung up 1,258 hitters. Their pitching staff has walked 504 opposing batters and their FIP comes in at 4.06 as a squad on the year.

The Guardians have dispatched 497 relief pitchers to the mound this season. The relievers have inherited 193 base runners on the season and 32.6% of them ended up scoring. They have earned 45 saves this year and have not converted 20 of their 65 save opportunities. The Guardians relief pitchers have recorded a save percentage of 69.2% and have come into the game in 174 save situations. The relievers have racked up 106 holds so far this season (3rd in MLB). Guardians bullpen pitchers have entered the contest with runners on base 141 times as well as having 179 appearances in high leverage situations.

The Cincinnati Reds have a tally of 4,029 putouts so far this season, as well as 1,252 assists and 93 errors. Their fielding percentage is holding steady at .983 which has them sitting 27th in the majors, and have earned 114 double plays. The Guardians have turned 69.8% of balls hit into play into outs out of their 12,087 innings on the field, ranking them 17th in the majors.

Allen has taken the hill for 366 frames and has tallied 309 strikeouts in his MLB career. Allen (22-24 career record) has a FIP of 4.48 and he has gone up against 1,597 opposing hitters during his time in the major leagues. His ERA is 4.55 (185 earned runs allowed) and he has a WHIP of 1.463. He has allowed 388 base hits (9.5 hits per nine innings) and has had 148 walks.

Minnesota has a total of 182 home runs on the campaign as well as 619 runs batted in. They have recorded 234 doubles, while taking a walk 473 times and notching 653 runs. The Minnesota Twins are sitting with an on-base percentage of .314 in addition to a team batting average of .240 so far this year. The Twins have a team SLG% of .400 and they are recording 4.30 runs per game (18th in baseball). They have been called out on strikes on 1,262 occasions (16th in the league) and have notched a total of 1,228 base hits.

The Twins are sitting with a team WHIP of 1.336 in addition to having a FIP of 4.16 as a pitching staff so far this season. They have earned a strikeout to walk ratio of 8.60 (1,278 strikeouts vs 437 bases on balls). They rank 28th in baseball as a pitching staff in total hits relinquished with 1,350. They have conceded 184 dingers and they surrender 4.98 runs per 9 innings (25th in the league). The Minnesota pitching staff have conceded 741 runs on the campaign and come in with a team ERA of 4.65 (692 earned runs relinquished).

Minnesota has had relief pitchers enter the contest in 51 save chances and they have tallied 27 saves. They rank 28th in the league holding a save percentage of 52.9%, and they have sent 515 relievers to the hill on the season. Their relief pitchers have come in 165 times in high leverage situations in addition to 114 occasions with runners on base. Minnesota bullpen pitchers have an inherited score percentage of 35.4% out of their 164 inherited base runners. Sitting with 143 save situations, the Twins have earned 90 holds in addition to 24 blown saves.

In their 12,042 innings on the field, the Twins have earned a defensive efficiency of 68.1% (29th in professional baseball). The Minnesota Twins have turned 92 double plays and have notched a fielding percentage of .985 (18th in MLB). The Twins have accrued 1,146 assists, 78 errors and are sitting with 4,014 putouts so far this year.

Lopez (59-53 career mark) has a 3.81 ERA while conceding 8.2 hits per nine innings. He has a strikeout to walk ratio of 3.98 and he has gone up against 3,978 hitters in his pro baseball career. He has given up 407 ER's while holding a WHIP of 1.176 and a FIP of 3.8. Thus far in his career, Lopez has allowed 880 hits while totaling 992 strikeouts in 960 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Minnesota (+220)

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