Cleveland Guardians vs Minnesota Twins Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Minnesota Twins

Date: Sunday, September 21, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Cleveland (-128) Minnesota (+106)

The Minnesota Twins (66-86) will try to beat the Cleveland Guardians (81-71) at Target Field on Sunday. The odds on this game have Cleveland at -128 while Minnesota opens at +106. The over/under has been set at 8.5. The starting pitchers will be Parker Messick and Joe Ryan.

The Guardians have hit 223 doubles as a team and have hit 157 balls out of the stadium. Cleveland is slugging .372 and have been called out on strikes 1,259 times, while being walked on 464 occasions. As a team, the Cleveland Guardians are earning 3.9 runs per outing, which puts them at 27th in MLB. They have earned 574 RBI's as well as 1,125 hits this year, while their team batting average is at .226. They have earned a total of 594 runs scored and hold an OBP of .297.

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They have earned a strikeout to walk ratio of 2.50 and the pitching staff has a team WHIP of 1.28. Guardians pitchers have surrendered 160 long balls in addition to 617 runs in total (6th in baseball). Cleveland has allowed 1,224 base knocks (8.1 per 9 innings) and 563 earned runs. The Guardians are sitting with a team earned run average of 3.75 this season (5th in baseball), and their staff has struck out 1,268 hitters. Their pitching staff has walked 508 opposing hitters and their FIP is 4.05 as a team so far this season.

Guardians relief pitchers have entered the game with opponents on base 141 times in addition to having 182 appearances in high leverage situations. The bullpen have recorded 108 holds so far this year (2nd in MLB). The Guardians bullpen have recorded a save percentage of 69.7% and have come into the game in 177 save situations. They have earned 46 saves so far this season and have blown 20 of 66 chances to save the game. The relievers have inherited 193 runners for the season and 32.6% of them ended up crossing the plate. The Guardians have dispatched 500 relievers to the hill this season.

The Guardians have turned 69.8% of balls hit into play into outs in their 12,087 innings on the diamond, which has them sitting at 17th in pro baseball. The Cincinnati Reds have notched a total of 4,029 putouts on the campaign, in addition to 1,252 assists and 93 errors. Their fielding percentage sits at .983 which is 27th in the majors, and they have turned 114 double plays.

Messick has taken the ball for 29 innings and is sitting with 22 strikeouts so far in his MLB career. Messick (3-0 career record) holds a FIP of 1.83 while going up against 120 opposing batters in the majors. His ERA is 1.86 (6 earned runs allowed) and he has a WHIP of 1.340. He has conceded 35 hits (10.8 hits per nine innings) and has 4 free passes.

The Minnesota Twins have a team on-base percentage of .314 and a batting average of .240 for the year. They have been rung up on 1,262 occasions (16th in baseball) and have tallied 1,228 base hits. Minnesota has tallied 182 home runs over the course of the season and 619 RBIs. The Twins hold a team slugging percentage of .400 and they tally 4.30 runs per outing (18th in the league). They have 234 two-baggers, while getting a free base 473 times and scoring 653 runs.

The Twins hold a team WHIP of 1.336 in addition to having a FIP of 4.16 as a unit so far this year. They currently have a K/BB ratio of 8.60 (1,278 strikeouts vs 437 walks). They have a ranking of 26th in MLB as a pitching staff in total hits conceded with 1,350. They have surrendered 184 home runs and they allow 4.98 runs per 9 innings (25th in MLB). The Minnesota pitching staff have relinquished 741 runs so far this year while having an ERA of 4.65 (692 earned runs yielded).

Minnesota relievers hold an inherited score percentage of 35.4% out of 164 inherited base runners. Their relievers have stepped onto the mound 165 times in high leverage situations in addition to 114 occasions with runners on. Sitting with 143 save situations, the Twins have 90 holds in addition to 24 blown saves. They sit at 28th in the league with a save rate of 52.9%, and they have dispatched 515 relievers onto the diamond for the season. Minnesota has called on relief pitchers to enter the game in 51 save chances and they have walked away with 27 saves.

Out of their 12,042 innings on the field, the Twins hold a defensive efficiency of 68.1% (29th in pro baseball). The Minnesota Twins have turned 92 double plays and have earned a fielding percentage of .985 (18th in pro baseball). The Twins have accrued 1,146 assists, 78 errors and have a tally of 4,014 putouts during this campaign.

In his pro baseball career, Ryan has allowed 524 base hits while tallying 705 punch outs in 631 innings. Ryan (46-34 record in his career) has a 3.78 earned run average and has surrendered 7.5 hits per 9 innings. He has surrendered 265 earned runs while earning a WHIP of 1.060 and a FIP of 3.7. He has a K/BB ratio of 4.86 and he has gone up against 2,560 batters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Minnesota (+106)

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