Detroit Tigers vs Cleveland Guardians Prediction, 9/25/2025 MLB Picks, Best Bets & Odds

Game: Detroit Tigers vs Cleveland Guardians

Date: Thursday, September 25, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Detroit (+102) Cleveland (-122)

Progressive Field is the location where the Cleveland Guardians (85-72) will try to beat the Detroit Tigers (85-72) on Thursday. The moneyline on this contest has Detroit at +102 while Cleveland is opening at -122. The over/under is 8.5. The starting pitchers will be Keider Montero and Parker Messick.

The Tigers have hit 241 two-baggers as a team and have knocked 194 baseballs out of the park. Detroit has a slugging percentage of .416 and have been called out on strikes 1,403 times, while drawing a walk on 493 occasions. As a unit, the Detroit Tigers are compiling 4.8 runs per outing, which is 10th in baseball. They have 711 runs batted in and 1,307 base knocks for the year, while their average at the plate is at .247. They have 745 runs while holding a team on-base percentage of .316.

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They have accumulated a K/BB ratio of 2.80 and the pitching staff has a team WHIP of 1.25. Tigers pitchers have surrendered 184 home runs and 675 runs in total (15th in the league). Detroit has surrendered 1,272 base hits (8.2 per 9 innings) in addition to 616 earned runs. The Tigers hold a team earned run average of 3.98 so far this season (16th in MLB), and they have rung up 1,328 hitters. Their pitching staff has walked 475 players from the other team and their FIP is 4.10 as a squad on the season.

The Tigers relief pitchers have compiled a save rate of 64.4% and have stepped onto the mound in 134 save situations. The relief pitchers have inherited 247 runners this year with 28.3% of those runners ended up scoring. Tigers pitchers have stepped onto the hill with runners on 175 times in addition to having 133 appearances in high leverage situations. The Tigers have dispatched 491 relief pitchers to the hill so far this season. The relief pitchers have accumulated 71 holds for the season (25th in the league). They have earned 38 saves for the season and have missed out on 21 of 59 save opportunities.

The Colorado Rockies have earned 4,182 putouts at this point in the season, as well as 1,347 assists and 76 errors. Their fielding percentage is holding steady at .986 which has them sitting 12th in professional baseball, and have accumulated 126 double plays. The Tigers have converted 70.2% of balls hit into play into outs in their 12,546 innings, which ranks them 13th in professional baseball.

Montero has taken the hill for 184 innings and has totaled 142 strikeouts in his MLB career. His ERA is 4.64 (95 earned runs allowed) and his WHIP is 1.368. He has given up 190 base knocks (9.3 hits per nine innings) with 62 walks. Montero (11-9 win-loss mark in his career) sits with a FIP of 4.57 while going up against 783 batters in the major leagues.

The Cleveland Guardians have accumulated an on-base percentage of .297 and a team batting average of .226 so far this year. They have been rung up on 1,299 instances (18th in MLB) and are sitting with 1,164 hits. Cleveland has recorded 163 home runs on the campaign and 599 RBIs. The Guardians hold a team SLG% of .373 and they score 3.96 runs per contest (27th in the league). They have put up 233 two-baggers, while walking 481 times as well as racking up 621 runs.

The Cleveland pitching staff have conceded 627 runs so far this year while having a team ERA of 3.69 (573 earned runs relinquished). They have allowed 163 homers and they yield 4.04 runs per 9 innings (5th in MLB). The Guardians have a WHIP of 1.267 with a FIP of 3.97 as a staff so far this season. They currently have a K/BB ratio of 8.60 (1,332 strikeouts against 517 walks). They come in at 11th in the league as a pitching staff in total hits given up with 1,252.

Cleveland relievers have an inherited score percentage of 33.5% out of their 200 inherited runners. Their relief pitchers have come in 188 times in high leverage situations and on 145 occasions with runners on base. Sitting with 182 save situations, the Guardians have accrued 110 holds and also 22 blown saves. They are currently ranked 4th in MLB with a save rate of 68.1%, and they have dispatched 513 relievers to the mound for the year. Cleveland has had bullpen pitchers enter the game in 69 save opportunities and they have come away with 47 saves.

The Cleveland Guardians have turned 120 double plays and have notched a fielding percentage of .983 (27th in pro baseball). The Guardians have 1,294 assists, 96 errors and have notched a total of 4,188 putouts on the campaign. In their 12,564 innings on the diamond, the Guardians hold a defensive efficiency of 69.8% (17th in professional baseball).

Messick (3-0 career record) has earned a 2.11 ERA and has conceded 10.5 hits per nine innings. He has a K/BB ratio of 6.20 and he has faced 142 opposing hitters in his MLB career. He has surrendered 8 ER's while holding a WHIP of 1.316 and a FIP of 2.1. In his pro baseball career, Messick has surrendered 40 hits while earning 31 strikeouts in 34 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (-122)

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