Houston Astros vs Chicago White Sox Prediction, 5/4/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Chicago White Sox

Date: Sunday, May 4, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Houston (-130) Chicago (+110)

The Chicago White Sox (8-23) welcome the Houston Astros (16-14) at Rate Field on Sunday. The odds on this game have the Astros at -130 and the White Sox are coming in at +110. The over/under has been set at 9. The expected starting pitchers are Ronel Blanco and Bryse Wilson.

Houston has a slugging % of .357 and have been called out on strikes 244 times, while taking a walk on 98 occasions. They have tallied 110 RBI's as well as 233 hits so far this season, while their team batting average is at .236. The Astros have accumulated 38 doubles as a squad and have knocked 25 balls out of the park. They have a total of 117 runs scored and hold an on-base percentage of .310. As a team, the Houston Astros are putting up 3.9 runs per game, which has them at 20th in MLB.

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The Astros have a team ERA of 3.23 on the year (5th in MLB), and the staff has rung up 275 hitters. Astros pitchers have given up 29 long balls and also 104 runs in total (3rd in the league). Their pitching staff has walked 82 opposing batters and their FIP is 3.43 as a unit this season. Houston has surrendered 208 base knocks (7.0 per 9 innings) and 96 earned runs. They have a K/BB ratio of 3.35 and the pitching staff holds a collective WHIP of 1.09.

Astros relief pitchers have stepped onto the hill with runners on base 22 times and also have had 26 appearances in high leverage situations. The relief pitchers are sitting with 22 holds on the campaign (8th in the league). The Astros bullpen have recorded a save rate of 75.0% and have entered the game in 34 save situations. They have accumulated 9 saves on the season and have blown 3 of 12 save opportunities. The relief pitchers have inherited 30 base runners over the course of the season with 30.0% of those players earned a run for their team. The Astros have sent 96 relief pitchers to the hill this year.

The Detroit Tigers have a total of 803 putouts so far this season, as well as 230 assists and 12 errors. Their fielding rate is holding steady at .989 which has them sitting 7th in MLB, and they have turned 17 double plays. The Astros have transformed 73.0% of baseballs in play into outs out of their 2,409 innings, which has them ranked 3rd in the majors.

Blanco has taken the ball for 253 frames and has racked up 251 strikeouts in his pro baseball career. Blanco (17-9 career mark) is the owner of a FIP of 3.46 and he has gone up against 1,054 opposing hitters in the majors. His ERA is 3.52 (99 ER's allowed) and he has a WHIP of 1.216. He has allowed 194 base hits (6.9 hits per nine innings) and has had 114 free passes.

Chicago has recorded 25 home runs on the season and 106 RBIs. They have tallied 40 two-baggers, while getting a free base 106 times and notching 109 runs. The Chicago White Sox have compiled a team on-base percentage of .291 in addition to a team batting average of .213 over the course of the season. The White Sox have a team slugging percentage of .329 and they average 3.52 runs per contest (25th in MLB). They have been called out on strikes on 259 occasions (12th in the league) and have totaled 215 base hits.

The White Sox hold a team WHIP of 1.356 and are the owners of a FIP of 4.67 as a pitching staff over the course of the season. Their K/BB ratio is 8.00 (238 strikeouts against 127 free passes). They are sitting at 7th in MLB as a staff in total hits surrendered with 235. They have allowed 35 long balls and they allow 4.48 runs per 9 innings (17th in the league). The Chicago pitching staff have surrendered 133 runs for the year while holding an ERA of 4.04 (120 earned runs allowed).

With 13 save situations, the White Sox have 9 holds and also 3 blown saves. Chicago has had relief pitchers step onto the mound in 4 save chances and they have come away with 1 save. Their relievers have taken the field 25 times in high leverage situations in addition to 28 occasions with runners on base. Chicago bullpen pitchers have an inherited score rate of 35.0% out of their 40 inherited runners. They are ranked 30th in the league holding a save rate of 25.0%, and they have sent 103 relievers to the hill for the season.

In their 2,403 innings on the diamond, the White Sox have earned a defensive efficiency of 70.8% (12th in the majors). The Chicago White Sox have turned 28 double plays and hold a fielding percentage of .978 (28th in pro baseball). The White Sox have accrued 255 assists, 24 errors and have earned a total of 801 putouts this season.

Wilson (20-22 win-loss mark in his career) has earned a 4.63 ERA while giving up 9.5 hits per 9 innings. His K/BB ratio is 2.24 and he has gone up against 1,868 hitters during his pro baseball career. He has surrendered 222 earned runs while holding a WHIP of 1.380 and being the owner of a FIP of 4.6. So far in his MLB career, Wilson has given up 454 hits while accumulating 316 K's in 431 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+110)

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