Houston Astros vs Los Angeles Angels Prediction, 6/22/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Los Angeles Angels

Date: Sunday, June 22, 2025

Location: Angel Stadium in Anaheim, CA

TV: FanDuel Sports Network West

Odds/Point Spread: Houston (-160) Los Angeles (+132)

The Houston Astros (43-32) are traveling to Angel Stadium on Sunday where they will compete against the Los Angeles Angels (36-38). The moneyline on this contest has the Astros at -160 and the Angels are at +132. The over/under is 8. The pitchers taking the mound are Ryan Gusto and Kyle Hendricks.

Houston has a slugging percentage of .402 and have struck out 575 times, while being walked on 218 occasions. They have tallied 307 runs batted in in addition to 649 hits this year, while their team batting average sits at .258. The Astros have hit 111 doubles as a team and have hit 79 balls out of the park. They have 321 runs and hold an on-base percentage of .324. As a unit, the Houston Astros are recording 4.3 runs per game, which puts them at 15th in the league.

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The Astros have an earned run average of 3.42 this season (6th in MLB), and their staff has struck out 734 hitters. Astros pitchers have relinquished 76 home runs and also 269 runs (3rd in the league). They have walked 229 opposing hitters and their FIP sits at 3.50 as a unit on the campaign. Houston has allowed 534 hits (7.3 per 9 innings) as well as 252 earned runs. Their strikeout to walk ratio sits at 3.21 and the pitching staff holds a collective WHIP of 1.15.

Astros pitchers have entered the game with runners on 55 times as well as having 70 appearances in high leverage situations. The bullpen have tallied 45 holds on the year (14th in MLB). The Astros relievers have accumulated a save percentage of 74.1% and have come into the game in 72 save situations. They have recorded 20 saves over the course of the season and have not converted 7 of 27 save opportunities. The bullpen pitchers have inherited 80 base runners for the season and 30.0% of those runners crossed home plate. The Astros have dispatched 231 relief pitchers to the hill on the year.

The Detroit Tigers have accumulated 1,988 putouts at this point in the season, as well as 564 assists and 35 errors. Their fielding percentage is currently at .986 which ranks 16th in baseball, and have a total of 48 double plays. The Astros have turned 71.1% of balls hit into play into outs in their 5,964 innings on the field, which has them sitting at 7th in professional baseball.

Gusto has pitched in 54 frames and is sitting with 60 K's during his MLB career. Gusto (4-3 win-loss mark in his career) has earned a FIP of 4.26 while facing 246 batters in the major leagues. His earned run average is 4.33 (26 ER's allowed) and his career WHIP is 1.534. He has allowed 60 hits (10.0 hits per nine innings) and has 23 free passes.

Los Angeles has compiled 105 home runs on the campaign as well as 292 RBIs. They have notched 96 doubles, while taking a walk 186 times as well as scoring 303 runs. The Los Angeles Angels have an OBP of .287 as well as a team batting average of .225 on the year. The Angels have a SLG% of .398 and they are recording 4.09 runs per game (22nd in the league). They have been rung up on 719 occasions (2nd in the league) and have earned 553 base knocks.

The Angels have a WHIP of 1.470 in addition to having a FIP of 4.71 as a pitching staff this season. Their strikeout to walk ratio sits at 7.80 (565 strikeouts vs 290 free passes). They come in at 27th in the league as a pitching staff in total hits surrendered with 667. They have given up 97 homers and they concede 5.02 runs per 9 innings (24th in the league). The Los Angeles pitching staff have given up 363 runs this season while having an ERA of 4.67 (338 earned runs yielded).

With 82 save situations, the Angels have 46 holds and also 13 blown saves. Los Angeles has had relief pitchers step onto the mound in 33 save opportunities and they have recorded 20 saves. Their bullpen pitchers have stepped onto the hill 92 times in high leverage situations and also on 74 occasions with runners on. Los Angeles relief pitchers have an inherited score rate of 31.9% of 116 inherited base runners. They are currently ranked 22nd in MLB with a save percentage of 60.6%, and they have sent 244 relievers to the hill for the year.

In their 5,862 innings on the diamond, the Angels have accumulated a defensive efficiency of 68.0% (26th in MLB). The Los Angeles Angels have gotten 86 double plays and have accounted for a fielding rate of .982 (27th in MLB). The Angels have recorded 666 assists, 48 errors and have a total of 1,954 putouts this year.

Hendricks (102-87 mark in his career) has a 3.74 earned run average while surrendering 8.6 hits per nine innings. He has a strikeout to walk ratio of 3.40 and he has faced 6,844 opposing hitters in his MLB career. He has conceded 688 ER's while holding a WHIP of 1.185 and being the owner of a FIP of 3.7. So far in his career, Hendricks has allowed 1,578 base knocks while he has tallied 1,312 strikeouts in 1,657 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Houston (-160)

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