Houston Astros vs Los Angeles Angels Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Los Angeles Angels

Date: Saturday, September 27, 2025

Location: Angel Stadium in Anaheim, CA

TV: FanDuel Sports Network West

Odds/Point Spread: Houston (-145) Los Angeles (+125)

The Los Angeles Angels (71-87) welcome the Houston Astros (84-74) at Angel Stadium on Saturday. The odds on this game have the Astros at -145 and the Angels are sitting at +125. The over/under is 9. The starting pitchers will be AJ Blubaugh and Caden Dana.

As a team, the Houston Astros are recording 4.2 runs per outing, which has them sitting at 25th in baseball. They have earned a total of 660 runs scored while holding a team OBP of .315. The Astros have earned 239 doubles as a squad and have knocked 172 balls out of the stadium. They have accounted for 630 runs batted in and 1,336 hits this year, while their batting average is sitting at .250. Houston has a slugging percentage of .396 and have struck out 1,263 times, while being walked on 458 occasions.

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The Astros are sitting with a team ERA of 3.88 this season (12th in MLB), and the staff has rung up 1,468 batters. Astros pitchers have surrendered 194 home runs and also 653 total runs (9th in MLB). They have walked 495 players from the other team and their FIP sits at 4.02 as a squad so far this season. Houston has allowed 1,228 hits (7.9 per 9 innings) and 607 earned runs. Their K/BB ratio is 2.97 and the pitching staff has a team WHIP of 1.22.

The Astros relievers have recorded a save rate of 73.8% and have stepped onto the mound in 152 save situations. The relievers have inherited 177 runners on the campaign and 23.2% of them crossed home plate. Astros pitchers have entered the contest with opponents on base 127 times in addition to having 166 appearances in high leverage situations. The Astros have sent 506 relievers to the hill on the year. The relief pitchers have earned 88 holds so far this year (15th in MLB). They have 45 saves this season and have blown 16 of 61 chances to get a save.

The Astros have transformed 70.7% of baseballs in play into outs in their 12,663 innings on the field, which ranks them 9th in pro baseball. The Detroit Tigers have a tally of 4,221 putouts for the season, in addition to 1,248 assists and 68 errors. Their fielding percentage is holding at .988 which is 8th in pro baseball, and they have turned 102 double plays.

Blubaugh has thrown 28 innings and has tallied 33 punch outs in his career. His earned run average is 1.93 (6 ER's allowed) and he has a career WHIP of 0.821. He has surrendered 16 base hits (5.1 hits per nine innings) with 7 free passes. Blubaugh (3-1 career mark) holds a FIP of 1.90 while he has faced 108 hitters during his time in the majors.

Los Angeles has knocked in 220 home runs on the year and 638 runs batted in. They have put up 209 doubles, while taking a walk 474 times and putting up 662 runs. The Los Angeles Angels have recorded an on-base percentage of .299 in addition to a team batting average of .226 on the campaign. The Angels hold a team slugging % of .398 and they average 4.19 runs per contest (24th in baseball). They have been called out on strikes on 1,590 instances (1st in MLB) and have recorded 1,185 base hits.

The Angels hold a team WHIP of 1.436 and are the owners of a FIP of 4.76 as a unit on the year. They have earned a K/BB ratio of 8.00 (1,243 strikeouts vs 610 bases on balls). They are currently ranked 26th in the league as a pitching staff in total hits relinquished with 1,394. They have given up 213 long balls and they yield 5.24 runs per 9 innings (28th in the league). The Los Angeles pitching staff have surrendered 813 runs over the course of the season while having an ERA of 4.86 (754 earned runs conceded).

Los Angeles has had relief pitchers step onto the mound in 71 save chances and they have converted 37 saves. They are currently ranked 30th in baseball with a save percentage of 52.1%, and they have dispatched 543 relievers onto the diamond for the year. Their bullpen pitchers have stepped onto the mound 204 times in high leverage situations in addition to 140 occasions with runners on base. Los Angeles relievers have an inherited score percentage of 37.7% out of 212 inherited base runners. With 156 save situations, the Angels have 82 holds and 34 blown saves.

In 12,558 innings on the diamond, the Angels have earned a defensive efficiency of 68.8% (24th in baseball). The Los Angeles Angels have gotten 158 double plays and have earned a fielding percentage of .983 (26th in the majors). The Angels have accrued 1,382 assists, 94 errors and have accumulated 4,186 putouts this year.

So far in his pro baseball career, Dana has conceded 39 base hits while he has earned 36 K's in 35 innings pitched. Dana (1-5 career win-loss record) holds a 7.41 ERA while conceding 10.0 hits per 9 innings. He has given up a total of 29 ER's while earning a WHIP of 1.790 and a FIP of 7.3. He has a K/BB ratio of 1.50 and he has gone up against 167 opposing batters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Houston (-145)

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