Houston Astros vs Sacramento Athletics Prediction, 9/25/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Sacramento Athletics

Date: Thursday, September 25, 2025

Location: Sutter Health Park in Sacramento, CA

TV: NBC Sports California

Odds/Point Spread: Houston (-150) Sacramento (+125)

The Sacramento Athletics (74-83) will compete against the Houston Astros (84-73) at Sutter Health Park on Thursday. The line on this contest has Houston at -150 and Sacramento is sitting at +125. The betting total is set at 9. The pitchers expected to start will be Framber Valdez and J.T. Ginn.

The Astros have hit 237 two-baggers as a unit and have hit 172 balls out of the park. Houston has a slugging rate of .397 and have been called out on strikes 1,254 times, while taking a walk on 457 occasions. As a squad, the Houston Astros are recording 4.2 runs per game, which is 24th in MLB. They have compiled 630 runs batted in and 1,331 base knocks on the campaign, while their average at the plate is .250. They have earned a total of 660 runs scored while having a team on-base percentage of .316.

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The Astros hold a team ERA of 3.87 over the course of the season (10th in baseball), and the staff has rung up 1,461 batters. Astros pitchers have allowed 192 home runs in addition to 647 total runs (9th in MLB). Their pitching staff has walked 492 opposing batters and their FIP comes in at 4.02 as a team on the campaign. Houston has conceded 1,220 base hits (7.8 per 9 innings) as well as 602 earned runs. Their strikeout to walk ratio is 2.97 and the pitching staff has a collective WHIP of 1.22.

The Astros have dispatched 503 relief pitchers to the hill this year. The bullpen pitchers have inherited 177 base runners for the season with 23.2% of them ended up crossing the plate. They have accumulated 45 saves so far this season and have blown 16 of their 61 chances to save the game. The Astros relief pitchers have earned a save percentage of 73.8% and have entered the game in 152 save situations. The bullpen have notched 88 holds this season (15th in MLB). Astros relief pitchers have come into the game with players on base 127 times and also have had 166 appearances in high leverage situations.

The Detroit Tigers have amassed 4,197 putouts this season, as well as 1,239 assists and 67 errors. Their fielding percentage is holding at .988 which ranks 7th in MLB, and have accumulated 102 double plays. The Astros have converted 70.7% of baseballs in play into outs out of their 12,591 innings on the field, which ranks them 8th in baseball.

Valdez has thrown 1,073 innings and has accumulated 1,043 strikeouts so far in his MLB career. Valdez (80-52 win-loss record in his career) holds a FIP of 3.33 and he has gone up against 4,453 opposing hitters during his time in the major leagues. His ERA is 3.38 (403 ER's allowed) and his WHIP is 1.204. He has surrendered 905 base knocks (7.6 hits per 9 innings) and has had 387 free passes.

The Sacramento Athletics hold an OBP of .318 in addition to a team batting average of .253 so far this season. They have been rung up on 1,357 instances (10th in baseball) and have earned 1,362 base hits. Sacramento has knocked in 214 home runs this year to go along with 690 RBIs. The Athletics hold a slugging percentage of .432 and they average 4.55 runs per outing (12th in MLB). They have put up 285 doubles, while taking a walk 486 times as well as notching 714 runs.

The Sacramento pitching staff have relinquished 790 runs on the year and come in with a team ERA of 4.69 (726 earned runs conceded). They have surrendered 217 dingers and they concede 5.11 runs per 9 innings (27th in the league). The Athletics hold a team WHIP of 1.360 in addition to having a FIP of 4.69 as a staff so far this season. Their strikeout to walk ratio comes in at 8.30 (1,282 strikeouts against 551 bases on balls). They rank 23rd in MLB as a staff in total hits relinquished with 1,343.

With 122 save situations, the Athletics have recorded 67 holds and 20 blown saves. Sacramento has had bullpen pitchers enter the game in 55 save chances and they have recorded 35 saves. Their relief pitchers have stepped onto the mound 139 times in high leverage situations and on 155 occasions with runners on base. Sacramento relievers hold an inherited score rate of 27.3% of 227 inherited base runners. They are currently ranked 15th in MLB holding a save percentage of 63.6%, and they have sent 494 relievers to the mound this year.

The Sacramento Athletics have turned 107 double plays and have accounted for a fielding rate of .985 (20th in pro baseball). The Athletics have recorded 1,174 assists, 84 errors and have 4,178 putouts this season. In 12,534 innings played, the Athletics hold a defensive efficiency of 69.8% (16th in baseball).

Ginn (5-7 career record) has a 4.49 ERA and has conceded 9.1 hits per nine innings. His K/BB ratio is 3.35 and he has faced 513 batters during his MLB career. He has conceded 60 earned runs while earning a WHIP of 1.323 and being the owner of a FIP of 4.4. So far in his pro baseball career, Ginn has conceded 122 hits while tallying 124 strikeouts in 120 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Sacramento (+125)

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