Los Angeles Angels vs Milwaukee Brewers Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Angels vs Milwaukee Brewers

Date: Tuesday, September 16, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Los Angeles (+220) Milwaukee (-275)

American Family Field is the site where the Milwaukee Brewers (91-59) will take on the Los Angeles Angels (69-81) on Tuesday. The odds on this game have Los Angeles at +220 and Milwaukee is coming in at -275. The over/under is set at 9. The pitchers expected to start will be Caden Dana and Freddy Peralta.

As a team, the Los Angeles Angels are knocking in 4.3 runs/g, which puts them at 23rd in the league. They are sitting with 639 runs scored and have an on-base percentage of .302. The Angels have accumulated 202 two-baggers as a team and have hit 207 baseballs out of the stadium. They have accumulated 617 runs batted in as well as 1,137 hits on the season, while their team batting average is sitting at .228. Los Angeles is slugging .399 and have struck out 1,496 times, while drawing a walk on 459 occasions.

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They have accumulated a K/BB ratio of 2.05 and the pitching staff has a collective WHIP of 1.44. Angels pitchers have conceded 209 home runs and 770 runs (28th in baseball). Los Angeles has conceded 1,330 hits (9.0 per 9 innings) and also 713 earned runs. The Angels are sitting with a team earned run average of 4.83 this season (28th in baseball), and the staff has struck out 1,186 batters. Their pitching staff has walked 578 opposing batters and their FIP comes in at 4.82 as a team this season.

The Angels relief pitchers have earned a save percentage of 51.5% and have entered the game in 149 save situations. The relief pitchers have inherited 204 base runners so far this season and 36.8% of those runners ended up scoring. Angels bullpen pitchers have gone to the mound with runners on 136 times in addition to having 198 appearances in high leverage situations. The Angels have sent 519 relief pitchers to the mound on the season. The relievers have 78 holds on the campaign (21st in baseball). They have accumulated 35 saves on the season and have blown 33 out of their 68 save chances.

The Angels have turned 68.8% of balls in play into outs out of 11,955 innings on the field, ranking them 24th in the majors. The Kansas City Royals have accumulated 3,985 putouts thus far, as well as 1,311 assists and 90 errors. Their fielding percentage is at .983 which ranks 26th in MLB, and have a total of 151 double plays.

Dana (1-3 career mark) holds a FIP of 7.71 while facing 123 batters in the majors. He has surrendered 28 hits (10.0 hits per nine innings) with 18 walks. His ERA is 7.83 (22 ER's allowed) and he has a WHIP of 1.818. Dana has taken the ball for 25 innings and has 27 punch outs during his career.

The Milwaukee Brewers have accounted for an on-base percentage of .333 as well as a team batting average of .260 so far this season. They have struck out on 1,170 occasions (25th in MLB) and are sitting with 1,330 base hits. Milwaukee has a total of 160 home runs for the year to go along with 707 RBIs. The Brewers hold a slugging % of .408 and they tally 5.08 runs per contest (3rd in MLB). They have hit 243 two-baggers, while walking 516 times as well as earning 762 runs.

The Milwaukee pitching staff have surrendered 589 runs for the year while having a team ERA of 3.63 (538 earned runs yielded). They have given up 154 HR's and they concede 3.97 runs per 9 innings (3rd in MLB). The Brewers have a team WHIP of 1.236 in addition to having a FIP of 3.93 as a staff so far this year. Their K/BB ratio is 8.90 (1,317 strikeouts vs 498 walks). They are currently ranked 3rd in MLB as a pitching staff in total hits conceded with 1,151.

Milwaukee relief pitchers hold an inherited score rate of 30.5% out of 197 inherited base runners. Their relief pitchers have stepped onto the mound 170 times in high leverage situations and on 133 occasions with base runners. With 165 save situations, the Brewers have earned 100 holds and 19 blown saves. They are currently ranked 5th in the league holding a save percentage of 68.9%, and they have dispatched 507 relief pitchers to the mound on the year. Milwaukee has called on relievers to take the mound in 61 save chances and they have come away with 42 saves.

The Milwaukee Brewers have turned 111 double plays and have a fielding percentage of .987 (9th in pro baseball). The Brewers have 1,202 assists, 68 errors and are sitting with 4,004 putouts during this campaign. Out of their 12,012 innings on the diamond, the Brewers have accumulated a defensive efficiency of 70.8% (5th in the majors).

Peralta (69-42 career win-loss record) has a 3.60 earned run average and has given up 6.7 hits per 9 innings. His strikeout to walk ratio is 3.18 and he has faced 3,802 batters during his pro baseball career. He has surrendered 367 earned runs while earning a WHIP of 1.136 and a FIP of 3.5. During his pro baseball career, Peralta has given up 685 base knocks while he has accumulated 1,134 K's in 917 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Milwaukee (-275)

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