Los Angeles Dodgers vs San Francisco Giants Prediction, 9/12/2025 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs San Francisco Giants

Date: Friday, September 12, 2025

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Los Angeles (-128) San Francisco (+106)

Oracle Park is the location where the San Francisco Giants (74-72) will meet the Los Angeles Dodgers (82-64) on Friday. The moneyline on this contest has Los Angeles at -128 while San Francisco is priced at +106. The over/under is 9. The pitchers taking the mound will be Yoshinobu Yamamoto and Justin Verlander.

Los Angeles has a slugging % of .437 and have struck out 1,222 times, while being walked on 531 occasions. They have earned 708 runs batted in in addition to 1,243 hits on the year, and their team batting average comes in at .252. The Dodgers have hit 230 doubles as a team and have hit 215 baseballs out of the park. They have a total of 738 runs scored while holding a team OBP of .328. As a unit, the Los Angeles Dodgers are scoring 5.1 runs per contest, which puts them at 2nd in baseball.

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The Dodgers have a team earned run average of 4.03 on the season (18th in baseball), and their staff has rung up 1,324 hitters. Dodgers pitchers have given up 164 home runs and also 627 runs (15th in baseball). They have walked 494 opposing hitters and their FIP comes in at 4.03 as a team so far this year. Los Angeles has surrendered 1,152 base hits (8.0 per 9 innings) and also 580 earned runs. Their strikeout to walk ratio sits at 2.68 and the pitching staff has recorded a WHIP of 1.27.

The Dodgers have dispatched 515 relief pitchers to the hill for the year. The relief pitchers have inherited 207 runners for the year and 26.1% of them ended up scoring. They have accumulated 39 saves over the course of the season and have blown 23 out of their 62 chances to get a save. The Dodgers relievers have a save percentage of 62.9% and have come into the game in 176 save situations. The relievers have a total of 109 holds on the year (1st in the league). Dodgers relief pitchers have stepped onto the hill with opponents on base 131 times in addition to having 157 appearances in high leverage situations.

The Dodgers have converted 70.1% of balls in play into outs out of 11,646 innings, ranking them 14th in baseball. The Los Angeles Angels have 3,882 putouts this year, as well as 1,232 assists and 61 errors. Their fielding percentage sits at .988 which is 6th in professional baseball, and they have turned 94 double plays.

Yamamoto has taken the mound for 245 frames and has racked up 282 strikeouts in his MLB career. His earned run average is 2.83 (77 earned runs allowed) and his WHIP is 1.049. He has surrendered 185 base hits (6.8 hits per 9 innings) and has 72 free passes. Yamamoto (18-10 career win-loss record) holds a FIP of 2.79 while facing 983 opposing batters during his time in the majors.

The Giants have a SLG% of .392 and they have an average of 4.36 runs per contest (16th in MLB). They have hit 217 doubles, while taking a walk 490 times as well as putting up 637 runs. San Francisco has hit 159 home runs this year and 608 runs batted in. They have struck out on 1,236 instances (13th in the league) and have a total of 1,161 base knocks. The San Francisco Giants have recorded an on-base percentage of .314 and a batting average of .239 this season.

The Giants have a WHIP of 1.289 with a FIP of 3.68 as a team on the year. They are currently ranked 19th in the league as a staff in total hits relinquished with 1,211. The San Francisco pitching staff have given up 605 runs on the season while holding a team ERA of 3.76 (539 earned runs yielded). They currently have a strikeout to walk ratio of 8.60 (1,235 strikeouts vs 453 bases on balls). They have given up 125 long balls and they allow 4.22 runs per 9 innings (10th in MLB).

San Francisco bullpen pitchers have an inherited score percentage of 35.7% of 171 inherited runners. Their bullpen pitchers have come in 152 times in high leverage situations in addition to 107 occasions with base runners. Sitting with 134 save situations, the Giants have compiled 79 holds in addition to 19 blown saves. They rank 10th in the league with a save rate of 65.5%, and they have sent 462 relievers to the hill this year. San Francisco has had bullpen pitchers enter the contest in 55 save chances and they have tallied 36 saves.

Out of their 11,625 innings played, the Giants hold a efficiency on defense of 68.4% (27th in professional baseball). The San Francisco Giants have turned 121 double plays and have notched a fielding percentage of .984 (23rd in the majors). The Giants have recorded 1,364 assists, 86 errors and have accumulated 3,875 putouts so far this season.

In his career, Verlander has allowed 3,025 hits and he has 3,536 strikeouts in 3,542 innings. He has surrendered 1,310 earned runs while holding a WHIP of 1.135 and a FIP of 3.3. He has a K/BB ratio of 3.55 and he has faced 14,505 batters in his pro baseball career. Verlander (265-157 career record) has a 3.33 ERA while giving up 7.7 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Francisco (+106)

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