Miami Marlins vs San Diego Padres Prediction, 5/28/2025 MLB Picks, Best Bets & Odds

Game: Miami Marlins vs San Diego Padres

Date: Wednesday, May 28, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Miami (+220) San Diego (-275)

The Miami Marlins (21-31) are headed to Petco Park on Wednesday where they will compete against the San Diego Padres (30-22). The moneyline on this contest has Miami at +220 and San Diego is opening at -275. The total has been set at 8.5. The starting pitchers are Sandy Alcantara and Kyle Hart.

As a squad, the Miami Marlins are notching 4.1 runs per game, which has them sitting at 20th in MLB. They have 213 runs while having a team on-base percentage of .314. The Marlins have recorded 85 doubles as a team and have hit 48 baseballs out of the stadium. They have 204 RBI's and 443 hits over the course of the season, and their team batting average is .249. Miami has a slugging % of .387 and have been rung up 435 times, while drawing a walk on 161 occasions.

Get all of our MLB Picks

The Marlins have an ERA of 5.21 this season (27th in the league), and the staff has struck out 418 batters. Marlins pitchers have conceded 64 home runs and also 289 total runs (27th in baseball). They have walked 200 players from the other team and their FIP is 4.48 as a unit this season. Miami has yielded 468 hits (9.1 per 9 innings) as well as 268 earned runs. They have a strikeout to walk ratio of 2.09 and the pitching staff has earned a collective WHIP of 1.44.

The Marlins have dispatched 174 relievers to the hill on the season. The bullpen pitchers have inherited 76 runners for the season and 35.5% of those runners crossed the plate. They have earned 9 saves this season and have not converted 9 out of their 18 save opportunities. The Marlins relievers have a save percentage of 50.0% and have come into the game in 44 save situations. The bullpen have racked up 26 holds this year (27th in the league). Marlins relief pitchers have gone to the mound with runners on base 53 times in addition to having 60 appearances in high leverage situations.

The Los Angeles Dodgers have earned a total of 1,389 putouts on the campaign, in addition to 459 assists and 26 errors. Their fielding percentage is at .986 which has them ranked 16th in MLB, and have a total of 36 double plays. The Marlins have converted 68.5% of balls hit into play into outs out of their 4,167 innings on the diamond, which has them sitting 22nd in the majors.

Alcantara has taken the hill for 947 innings and is sitting with 829 punch outs in his career. Alcantara (43-62 career win-loss mark) has a FIP of 3.50 while he has faced 3,896 batters in the major leagues. His ERA is 3.55 (374 earned runs allowed) and he has a WHIP of 1.178. He has allowed 818 base knocks (7.8 hits per 9 innings) and has 298 free passes.

San Diego has accounted for 49 home runs so far this year to go along with 198 RBIs. They have recorded 76 doubles, while taking a walk 160 times and scoring 217 runs. The San Diego Padres have accounted for a team OBP of .317 in addition to a team batting average of .251 for the year. The Padres have a team slugging % of .388 and they have an average of 4.17 runs per outing (17th in the league). They have struck out on 371 instances (30th in the league) and have 435 hits.

The Padres have a WHIP of 1.193 with a FIP of 3.83 as a pitching staff this season. Their K/BB ratio sits at 8.90 (458 strikeouts against 169 bases on balls). They are sitting at 3rd in the league as a staff in total hits given up with 381. They have given up 54 dingers and they yield 3.89 runs per 9 innings (10th in baseball). The San Diego pitching staff have given up 199 runs this year and come in with a team ERA of 3.49 (179 earned runs yielded).

San Diego has had relief pitchers step onto the mound in 24 save opportunities and they have come away with 18 saves. They are ranked 3rd in MLB with a save percentage of 75.0%, and they have dispatched 181 bullpen pitchers onto the diamond over the course of the season. Their relief pitchers have come in 68 times in high leverage situations and also on 52 occasions with runners on base. San Diego relievers have an inherited score rate of 39.4% of 71 inherited base runners. With 60 save situations, the Padres have earned 35 holds and 6 blown saves.

In their 4,149 innings on the diamond, the Padres hold a efficiency on defense of 71.7% (7th in baseball). The San Diego Padres have turned 40 double plays and have earned a fielding percentage of .985 (20th in pro baseball). The Padres have 392 assists, 27 errors and have notched a total of 1,383 putouts this season.

Hart (2-3 record in his career) has a 9.28 ERA while surrendering 13.2 hits per nine innings. His strikeout to walk ratio is 1.81 and he has faced 157 hitters in his MLB career. He has conceded a total of 33 earned runs while holding a WHIP of 1.969 and having a FIP of 9.1. So far in his pro baseball career, Hart has surrendered 47 base hits and he has 29 strikeouts in 32 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Diego (-275)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here