Milwaukee Brewers vs Chicago Cubs Prediction, 8/20/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Chicago Cubs

Date: Wednesday, August 20, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Milwaukee (-132) Chicago (+110)

The Milwaukee Brewers (79-45) are traveling to Wrigley Field on Wednesday where they will go up against the Chicago Cubs (70-54). The line on this matchup has Milwaukee at -132 while Chicago is at +110. The over/under has been set at 9. The expected starting pitchers are Jacob Misiorowski and Colin Rea.

As a team, the Milwaukee Brewers are notching 5.2 runs per game, which has them at 1st in the league. They are sitting with 645 runs scored while holding a team on-base percentage of .333. The Brewers have hit 196 two-baggers as a team and have smacked 134 baseballs out of the stadium. They have 598 RBI's as well as 1,091 base knocks so far this year, while their average at the plate is sitting at .259. Milwaukee is slugging .407 and have struck out 979 times, while taking a walk on 429 occasions.

Get all of our MLB Expert Picks

The Brewers are sitting with a team earned run average of 3.56 this year (2nd in baseball), and the staff has rung up 1,077 batters. Brewers pitchers have given up 134 home runs and also 477 runs in total (3rd in the league). They have walked 410 opposing batters and their FIP sits at 3.98 as a squad on the year. Milwaukee has surrendered 946 hits (7.7 per 9 innings) as well as 438 earned runs. They have earned a strikeout to walk ratio of 2.63 and the pitching staff has a team WHIP of 1.23.

The Brewers bullpen have a save percentage of 72.0% and have entered the game in 140 save situations. The relief pitchers have inherited 167 base runners over the course of the season with 31.7% of them crossed home plate. Brewers pitchers have entered the game with runners on base 111 times as well as having 142 appearances in high leverage situations. The Brewers have dispatched 425 relievers to the hill on the campaign. The relief pitchers have recorded 86 holds on the campaign (3rd in baseball). They have earned 36 saves for the season and have blown 14 of 50 save chances.

The Miami Marlins have notched a total of 3,320 putouts this year, in addition to 1,005 assists and 57 errors. Their fielding rate is holding steady at .987 which has them ranked 11th in MLB, and have a total of 88 double plays. The Brewers have turned 71.4% of balls hit into play into outs out of 9,960 innings, which ranks them 3rd in pro baseball.

Misiorowski has taken the hill for 34 innings and has 50 strikeouts during his pro baseball career. His earned run average is 3.95 (15 earned runs allowed) and his WHIP is 1.140. He has conceded 22 base hits (5.8 hits per nine innings) and has had 17 free passes. Misiorowski (4-1 win-loss mark in his career) has a FIP of 3.89 while he has gone up against 140 hitters during his time in the majors.

The Chicago Cubs have an on-base percentage of .319 in addition to a team batting average of .250 so far this season. They have been rung up on 958 occasions (27th in baseball) and have accounted for 1,059 base hits. Chicago has a total of 170 home runs for the year and 598 RBIs. The Cubs hold a team slugging % of .429 and they are earning 4.95 runs per game (5th in the league). They have put up 204 doubles, while getting a free base 416 times as well as scoring 614 runs.

The Chicago pitching staff have surrendered 504 runs on the season while holding a team ERA of 3.84 (469 earned runs conceded). They have allowed 153 dingers and they relinquish 4.12 runs per 9 innings (6th in MLB). The Cubs have a WHIP of 1.206 with a FIP of 4.19 as a unit for the year. They currently have a K/BB ratio of 7.70 (945 strikeouts against 320 walks). They are sitting at 12th in MLB as a staff in total hits allowed with 1,007.

Sitting with 124 save situations, the Cubs have recorded 78 holds and 14 blown saves. Chicago has had bullpen pitchers enter the game in 43 save chances and they have tallied 29 saves. Their bullpen pitchers have taken the field 118 times in high leverage situations in addition to 83 occasions with runners on. Chicago relievers hold an inherited score percentage of 29.7% of 118 inherited base runners. They are currently ranked 7th in the league with a save rate of 67.4%, and they have sent 405 bullpen pitchers to the hill so far this season.

The Chicago Cubs have gotten 95 double plays and have a fielding percentage of .988 (7th in baseball). The Cubs have racked up 1,037 assists, 52 errors and have accounted for 3,302 putouts over the course of the season. In their 9,906 innings on the field, the Cubs hold a efficiency on defense of 71.4% (4th in baseball).

Rea (35-25 career mark) has earned a 4.46 earned run average and has surrendered 8.8 hits per 9 innings. His strikeout to walk ratio is 2.67 and he has gone up against 2,414 batters during his MLB career. He has conceded a total of 281 ER's while holding a WHIP of 1.280 and being the owner of a FIP of 4.4. During his career, Rea has given up 555 hits and he has 456 punch outs in 567 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Milwaukee (-132)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here