Milwaukee Brewers vs Pittsburgh Pirates Prediction, 9/5/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Pittsburgh Pirates

Date: Friday, September 5, 2025

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: Milwaukee (-275) Pittsburgh (+220)

PNC Park is the site where the Pittsburgh Pirates (63-77) will attempt to beat the Milwaukee Brewers (86-54) on Friday. The moneyline on this contest has the Brewers at -275 and the Pirates are sitting at +220. The over/under comes in at 9. The starting pitchers are Quinn Priester and Johan Oviedo.

The Brewers have hit 227 two-baggers as a team and have knocked 152 balls out of the park. Milwaukee has a slugging percentage of .409 and have struck out 1,095 times, while drawing a walk on 484 occasions. As a squad, the Milwaukee Brewers are scoring 5.1 runs per game, which has them sitting at 2nd in MLB. They have earned 667 runs batted in as well as 1,233 hits this year, while their average at the plate sits at .259. They have earned 717 runs scored and hold an on-base percentage of .333.

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The Brewers have a team earned run average of 3.65 on the year (2nd in the league), and their staff has rung up 1,221 hitters. Brewers pitchers have relinquished 148 home runs and also 553 runs in total (4th in MLB). Their pitching staff has walked 462 opposing hitters and their FIP sits at 3.97 as a unit so far this season. Milwaukee has allowed 1,083 hits (7.8 per 9 innings) and 505 earned runs. They have accrued a K/BB ratio of 2.64 and their pitching staff holds a collective WHIP of 1.24.

Brewers relief pitchers have stepped onto the hill with players on base 125 times in addition to having 164 appearances in high leverage situations. The relief pitchers have notched 97 holds this year (2nd in the league). The Brewers bullpen have compiled a save rate of 67.8% and stepped onto the hill in 160 save situations. They have 40 saves on the year and have blown 19 of their 59 save chances. The relief pitchers have inherited 187 runners on the year and 30.5% of those runners earned a run for their team. The Brewers have dispatched 475 relief pitchers to the mound on the campaign.

The Brewers have converted 70.8% of balls hit into play into outs out of 11,220 innings on the diamond, which has them ranked 6th in the majors. The Miami Marlins have accounted for 3,740 putouts at this point in the season, as well as 1,119 assists and 64 errors. Their fielding percentage sits at .987 which has them ranked 10th in the majors, and they have turned 104 double plays.

Priester has taken the hill for 233 frames and has accumulated 176 K's thus far in his career. Priester (17-11 career win-loss mark) has earned a FIP of 4.48 and he has gone up against 1,013 hitters during his time in the majors. His ERA is 4.55 (118 ER's allowed) and he has a WHIP of 1.380. He has allowed 236 base knocks (9.1 hits per nine innings) and has had 86 free passes.

The Pirates hold a slugging percentage of .353 and they score 3.66 runs per game (30th in baseball). They have hit 210 two-baggers, while walking 460 times and notching 512 runs. Pittsburgh has a total of 102 home runs on the season to go along with 492 RBIs. They have been rung up on 1,216 occasions (9th in the league) and have notched a total of 1,086 base knocks. The Pittsburgh Pirates have earned an OBP of .308 as well as a team batting average of .234 on the campaign.

The Pittsburgh pitching staff have conceded 569 runs on the year while holding a team ERA of 3.88 (532 earned runs conceded). They have allowed 134 homers and they concede 4.15 runs per 9 innings (7th in the league). The Pirates hold a team WHIP of 1.218 and are the owners of a FIP of 3.90 as a unit on the campaign. They have earned a K/BB ratio of 8.00 (1,104 strikeouts vs 404 walks). They come in at 7th in baseball as a pitching staff in total hits conceded with 1,099.

Pittsburgh bullpen pitchers hold an inherited score percentage of 36.9% out of their 187 inherited runners. Their relief pitchers have come in 133 times in high leverage situations and also on 120 occasions with runners on. With 119 save situations, the Pirates have accumulated 64 holds and also 21 blown saves. They sit at 23rd in the league with a save percentage of 60.4%, and they have dispatched 434 bullpen pitchers to the mound for the year. Pittsburgh has had bullpen pitchers enter the contest in 53 save chances and they have come away with 32 saves.

Out of their 11,112 innings played, the Pirates hold a defensive efficiency of 70.9% (5th in baseball). The Pittsburgh Pirates have turned 101 double plays and have a fielding percentage of .986 (13th in professional baseball). The Pirates have 1,165 assists, 67 errors and have notched a total of 3,704 putouts during this campaign.

Thus far in his career, Oviedo has allowed 305 base knocks while he has accumulated 299 K's in 335 frames. He has surrendered a total of 160 earned runs while holding a WHIP of 1.390 and having a FIP of 4.2. He has a strikeout to walk ratio of 1.86 and he has faced 1,486 opposing batters during his MLB career. Oviedo (15-25 career mark) is the owner of a 4.30 ERA while allowing 8.2 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (+220)

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