Milwaukee Brewers vs San Diego Padres Prediction, 9/22/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs San Diego Padres

Date: Monday, September 22, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Milwaukee (-152) San Diego (+126)

The Milwaukee Brewers (94-59) are traveling to Petco Park on Monday where they will try to beat the San Diego Padres (83-70). The moneyline on this matchup has Milwaukee at -152 while San Diego is sitting at +126. The betting total comes in at 8.5. The expected starting pitchers are Freddy Peralta and Nick Pivetta.

As a squad, the Milwaukee Brewers are putting up 5.1 runs/g, which is 2nd in the league. They have accounted for 785 runs and hold an on-base percentage of .334. The Brewers have accumulated 251 doubles as a unit and have smacked 162 baseballs out of the stadium. They have earned 729 RBI's in addition to 1,357 hits on the season, and their team batting average is at .261. Milwaukee has a slugging rate of .409 and have struck out 1,187 times, while drawing a walk on 533 occasions.

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The Brewers hold a team earned run average of 3.60 on the year (2nd in the league), and the staff has rung up 1,361 hitters. Brewers pitchers have conceded 159 home runs in addition to 595 total runs (2nd in MLB). They have walked 502 opposing hitters and their FIP sits at 3.91 as a unit on the year. Milwaukee has relinquished 1,164 base knocks (7.7 per 9 innings) and also 544 earned runs. They have a strikeout to walk ratio of 2.71 and their pitching staff sits with a WHIP of 1.22.

Brewers relief pitchers have gone to the mound with runners on 134 times as well as having 171 appearances in high leverage situations. The relievers have earned 101 holds so far this season (5th in MLB). The Brewers relief pitchers have a save percentage of 69.4% and have entered the game in 167 save situations. They have compiled 43 saves on the campaign and have not converted 19 out of their 62 save chances. The relievers have inherited 199 runners on the year with 30.2% of them ended up scoring. The Brewers have sent 516 relief pitchers to the hill this season.

The Brewers have transformed 70.9% of balls in play into outs out of their 12,255 innings, which has them sitting at 6th in baseball. The Miami Marlins have accumulated 4,085 putouts over the course of the season, as well as 1,213 assists and 70 errors. Their fielding rate is at .987 which is 10th in MLB, and they have turned 111 double plays.

Peralta has taken the ball for 923 innings and has 1,144 strikeouts so far in his MLB career. His ERA is 3.59 (368 earned runs allowed) and he has a career WHIP of 1.133. He has allowed 687 base hits (6.7 hits per 9 innings) and has had 359 free passes. Peralta (70-42 career win-loss mark) is the owner of a FIP of 3.53 and he has gone up against 3,824 hitters during his time in the major leagues.

San Diego has 140 HRs so far this season as well as 615 runs batted in. They have hit 244 two-baggers, while taking a walk 484 times as well as scoring 652 runs. The San Diego Padres have earned an on-base percentage of .321 in addition to a batting average of .252 so far this season. The Padres hold a team SLG% of .389 and they score 4.26 runs per game (22nd in the league). They have struck out on 1,085 instances (28th in baseball) and have earned 1,288 hits.

The Padres hold a team WHIP of 1.204 and have a FIP of 4.04 as a team over the course of the season. They currently have a K/BB ratio of 8.90 (1,341 strikeouts vs 492 walks). They have a ranking of 1st in MLB as a pitching staff in total hits relinquished with 1,135. They have conceded 171 long balls and they relinquish 3.97 runs per 9 innings (3rd in the league). The San Diego pitching staff have allowed 596 runs so far this year while having a team ERA of 3.69 (554 earned runs yielded).

With 166 save situations, the Padres have accumulated 98 holds and 16 blown saves. San Diego has had bullpen pitchers step onto the hill in 63 save chances and they have tallied 47 saves. Their bullpen pitchers have come in 199 times in high leverage situations and also on 174 occasions with base runners. San Diego relievers hold an inherited score percentage of 29.7% out of their 246 inherited runners. They rank 1st in baseball with a save rate of 74.6%, and they have sent 541 relief pitchers onto the field for the year.

In their 12,159 innings played, the Padres have a defensive efficiency of 71.7% (2nd in MLB). The San Diego Padres have gotten 107 double plays and have a fielding rate of .987 (12th in the majors). The Padres have recorded 1,151 assists, 70 errors and have notched a total of 4,053 putouts this year.

During his MLB career, Pivetta has allowed 1,103 base knocks while he has accumulated 1,324 punch outs in 1,205 innings. He has given up a total of 599 earned runs while holding a WHIP of 1.265 and being the owner of a FIP of 4.4. He has a K/BB ratio of 3.14 and he has faced 5,082 hitters thus far in his career. Pivetta (69-76 win-loss record in his career) is the owner of a 4.47 ERA and has surrendered 8.2 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Milwaukee (-152)

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