Milwaukee Brewers vs San Diego Padres Prediction, 9/23/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs San Diego Padres

Date: Tuesday, September 23, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Milwaukee (-160) San Diego (+132)

The San Diego Padres (85-71) will compete against the Milwaukee Brewers (95-61) at Petco Park on Tuesday. The line on this contest has Milwaukee at -160 and San Diego is sitting at +132. The total is set at 9. The pitchers who are expected to start are Bruce Zimmermann and Randy Vasquez.

As a team, the Milwaukee Brewers are knocking in 5.1 runs per game, which has them sitting at 3rd in the league. They have notched a total of 789 runs and have an OBP of .334. The Brewers have accounted for 256 doubles as a squad and have hit 163 balls out of the stadium. They have earned 733 RBI's and 1,378 base knocks on the year, and their team batting average is at .261. Milwaukee has a slugging % of .409 and have struck out 1,203 times, while drawing a walk on 537 occasions.

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Their strikeout to walk ratio is 2.72 and their pitching staff holds a WHIP of 1.23. Brewers pitchers have relinquished 159 home runs in addition to 604 runs (3rd in MLB). Milwaukee has surrendered 1,187 base knocks (7.7 per 9 innings) and also 553 earned runs. The Brewers have a team earned run average of 3.61 over the course of the season (2nd in baseball), and their staff has rung up 1,374 batters. They have walked 506 opposing hitters and their FIP sits at 3.89 as a team this season.

Brewers relief pitchers have entered the game with runners on 138 times in addition to having 176 appearances in high leverage situations. The relief pitchers are sitting with 101 holds for the season (5th in MLB). The Brewers relief pitchers have accumulated a save rate of 69.4% and have come into the game in 167 save situations. They have 43 saves so far this year and have blown 19 of 62 save opportunities. The bullpen pitchers have inherited 208 runners this year with 30.8% of those runners ended up crossing the plate. The Brewers have dispatched 523 relievers to the mound over the course of the season.

The Brewers have converted 70.7% of baseballs in play into outs in their 12,417 innings on the diamond, ranking them 8th in professional baseball. The Miami Marlins have notched a total of 4,139 putouts at this point in the season, in addition to 1,239 assists and 72 errors. Their fielding percentage sits at .987 which has them ranked 11th in MLB, and they have turned 117 double plays.

Zimmermann (8-10 career record) has a FIP of 5.50 while he has faced 697 batters in the major leagues. He has conceded 195 base hits (11.1 hits per 9 innings) with 36 walks. His ERA is 5.58 (98 earned runs allowed) and his WHIP is 1.461. Zimmermann has taken the hill for 158 innings and has accounted for 126 K's so far in his career.

The Padres have a team slugging % of .388 and they earn 4.27 runs per outing (18th in baseball). They have recorded 248 doubles, while getting a free base 488 times as well as notching 662 runs. San Diego has tallied 141 HRs over the course of the season as well as 625 runs batted in. They have been rung up on 1,102 instances (28th in baseball) and have totaled 1,306 base knocks. The San Diego Padres have accounted for an on-base percentage of .321 as well as a team batting average of .252 this year.

The San Diego pitching staff have surrendered 603 runs on the year while having a team ERA of 3.69 (561 earned runs given up). They have given up 173 homers and they allow 3.97 runs per 9 innings (3rd in the league). The Padres are sitting with a team WHIP of 1.202 and are the owners of a FIP of 4.03 as a pitching staff on the campaign. Their strikeout to walk ratio comes in at 8.90 (1,356 strikeouts vs 497 bases on balls). They are currently ranked 1st in baseball as a staff in total hits relinquished with 1,147.

Sitting with 167 save situations, the Padres have accumulated 99 holds and 16 blown saves. San Diego has called on relief pitchers to enter the contest in 63 save chances and they have walked away with 47 saves. Their relief pitchers have stepped onto the mound 199 times in high leverage situations and on 175 occasions with runners on. San Diego relief pitchers have an inherited score percentage of 29.6% out of their 247 inherited base runners. They are ranked 1st in the league with a save rate of 74.6%, and they have sent 547 bullpen pitchers to the mound on the season.

In 12,312 innings played, the Padres hold a defensive efficiency of 71.8% (2nd in pro baseball). The San Diego Padres have gotten 109 double plays and have accounted for a fielding rate of .987 (9th in pro baseball). The Padres have recorded 1,168 assists, 70 errors and have notched a total of 4,104 putouts this year.

Thus far in his career, Vasquez has surrendered 270 base hits and he has 169 K's in 260 innings pitched. Vasquez (11-16 mark in his career) has earned a 4.15 ERA while allowing 9.3 hits per 9 innings. He has surrendered 120 ER's while earning a WHIP of 1.409 and a FIP of 4.1. He has a K/BB ratio of 1.74 and he has gone up against 1,137 batters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Milwaukee (-160)

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