Milwaukee Brewers vs St. Louis Cardinals Prediction, 9/20/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs St. Louis Cardinals

Date: Saturday, September 20, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Milwaukee (-132) St. Louis (+110)

The St. Louis Cardinals (74-79) host the Milwaukee Brewers (93-59) at Busch Stadium on Saturday. The moneyline on this contest has Milwaukee at -132 while St. Louis is coming in at +110. The total is 8. The expected starting pitchers are Chad Patrick and Miles Mikolas.

Milwaukee owns a slugging percentage of .409 and have been called out on strikes 1,185 times, while drawing a walk on 528 occasions. They have accounted for 724 runs batted in and 1,348 base knocks on the season, while their average at the plate is sitting at .261. The Brewers have compiled 248 doubles as a team and have knocked 162 baseballs out of the park. They have notched a total of 780 runs while holding a team OBP of .334. As a team, the Milwaukee Brewers are scoring 5.1 runs per game, which has them at 2nd in baseball.

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The Brewers hold a team earned run average of 3.61 so far this season (2nd in MLB), and their staff has rung up 1,345 hitters. Brewers pitchers have relinquished 158 long balls and 593 total runs (3rd in the league). They have walked 500 opposing players and their FIP is 3.92 as a unit so far this year. Milwaukee has given up 1,157 base hits (7.7 per 9 innings) in addition to 542 earned runs. Their strikeout to walk ratio sits at 2.69 and their pitching staff holds a WHIP of 1.23.

Brewers bullpen pitchers have entered the contest with runners on base 133 times and also have had 170 appearances in high leverage situations. The relief pitchers have a total of 100 holds for the year (5th in baseball). The Brewers relief pitchers have compiled a save rate of 68.9% and have come into the game in 165 save situations. They have recorded 42 saves so far this year and have blown 19 of their 61 save opportunities. The bullpen pitchers have inherited 197 base runners so far this season with 30.5% of those players earned a run for their team. The Brewers have sent 513 relief pitchers to the mound this season.

The Miami Marlins have earned a total of 4,058 putouts this year, in addition to 1,207 assists and 69 errors. Their fielding percentage sits at .987 which ranks 10th in the majors, and have earned 111 double plays. The Brewers have converted 71.0% of balls hit into play into outs out of 12,174 innings on the field, which has them ranked 4th in pro baseball.

Patrick has taken the mound for 111 innings and has 116 K's during his career. His earned run average is 3.65 (45 ER's allowed) and he has a career WHIP of 1.287. He has surrendered 106 hits (8.6 hits per nine innings) and has 37 walks. Patrick (3-8 record in his career) has a FIP of 3.59 and he has faced 469 hitters during his time in the majors.

The Cardinals hold a team slugging percentage of .378 and they are earning 4.27 runs per game (21st in the league). They have 243 doubles, while taking a walk 451 times as well as racking up 653 runs. St. Louis has tallied 142 home runs so far this season to go along with 620 runs batted in. They have struck out on 1,240 occasions (21st in the league) and are sitting with 1,255 base hits. The St. Louis Cardinals have a team on-base percentage of .314 as well as a team batting average of .244 for the year.

The Cardinals hold a team WHIP of 1.320 in addition to having a FIP of 4.04 as a unit over the course of the season. They have earned a K/BB ratio of 7.50 (1,135 strikeouts against 438 walks). They are sitting at 26th in MLB as a staff in total hits surrendered with 1,349. They have conceded 156 homers and they surrender 4.73 runs per 9 innings (22nd in the league). The St. Louis pitching staff have allowed 711 runs this year while holding an ERA of 4.29 (645 earned runs surrendered).

Sitting with 152 save situations, the Cardinals have earned 86 holds in addition to 22 blown saves. St. Louis has called on bullpen pitchers to step onto the mound in 62 save chances and they have come away with 40 saves. Their bullpen pitchers have stepped onto the mound 148 times in high leverage situations and on 148 occasions with runners on. St. Louis relievers hold an inherited score rate of 33.0% out of 206 inherited runners. They are currently ranked 12th in the league with a save rate of 64.5%, and they have dispatched 456 bullpen pitchers to the mound on the season.

In their 12,186 innings on the field, the Cardinals hold a defensive efficiency of 69.0% (22nd in MLB). The St. Louis Cardinals have turned 121 double plays and have notched a fielding percentage of .987 (13th in the majors). The Cardinals have racked up 1,465 assists, 75 errors and have a total of 4,062 putouts so far this season.

During his MLB career, Mikolas has given up 1,266 hits while he has tallied 888 strikeouts in 1,242 frames. He has given up a total of 584 earned runs while earning a WHIP of 1.215 and having a FIP of 4.2. His K/BB ratio is 3.65 and he has faced 5,174 opposing hitters so far in his MLB career. Mikolas (72-74 win-loss mark in his career) is the owner of a 4.23 ERA while giving up 9.2 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+110)

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