Milwaukee Brewers vs St. Louis Cardinals Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs St. Louis Cardinals

Date: Sunday, September 21, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Milwaukee (-150) St. Louis (+125)

The St. Louis Cardinals (74-79) are hosting the Milwaukee Brewers (94-59) at Busch Stadium on Sunday. The moneyline on this contest has the Brewers at -150 while the Cardinals are sitting at +125. The over/under comes in at 9. The pitchers taking the mound will be Chad Patrick and Miles Mikolas.

Milwaukee has a slugging % of .409 and have been called out on strikes 1,187 times, while drawing a walk on 533 occasions. They have 729 runs batted in in addition to 1,357 hits so far this year, and their batting average is .261. The Brewers have accounted for 251 doubles as a team and have hit 162 baseballs out of the park. They have earned a total of 785 runs scored and hold an on-base percentage of .334. As a team, the Milwaukee Brewers are compiling 5.1 runs per game, which has them sitting at 2nd in the league.

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Their K/BB ratio is 2.71 and their pitching staff has a collective WHIP of 1.22. Brewers pitchers have conceded 159 home runs and also 595 runs in total (2nd in the league). Milwaukee has conceded 1,164 hits (7.7 per 9 innings) and also 544 earned runs. The Brewers have an ERA of 3.60 so far this year (2nd in baseball), and the staff has struck out 1,361 hitters. Their pitching staff has walked 502 hitters and their FIP is 3.91 as a team for the year.

The Brewers have sent 516 relief pitchers to the hill this year. The bullpen pitchers have inherited 199 runners over the course of the season and 30.2% of those runners crossed the plate. They have accumulated 43 saves on the campaign and have not converted 19 of their 62 save opportunities. The Brewers relievers have earned a save rate of 69.4% and have come into the game in 167 save situations. The relievers have 101 holds this year (5th in baseball). Brewers bullpen pitchers have come into the game with runners on base 134 times in addition to having 171 appearances in high leverage situations.

The Miami Marlins have 4,058 putouts so far this season, as well as 1,207 assists and 69 errors. Their fielding rate is holding steady at .987 which ranks 10th in MLB, and they have turned 111 double plays. The Brewers have transformed 71.0% of balls hit into play into outs out of their 12,174 innings on the field, ranking them 4th in pro baseball.

Patrick has taken the hill for 111 innings and has racked up 116 punch outs during his career. His earned run average is 3.65 (45 ER's allowed) and he has a career WHIP of 1.287. He has allowed 106 base hits (8.6 hits per 9 innings) with 37 free passes. Patrick (3-8 win-loss mark in his career) is the owner of a FIP of 3.59 and he has gone up against 469 hitters in the major leagues.

The St. Louis Cardinals have earned a team on-base percentage of .314 in addition to a team batting average of .244 on the year. They have been called out on strikes on 1,240 instances (22nd in the league) and have 1,255 base hits. St. Louis has tallied 142 home runs this year to go along with 620 runs batted in. The Cardinals have a team SLG% of .378 and they tally 4.27 runs per game (19th in baseball). They have tallied 243 two-baggers, while taking a walk 451 times and notching 653 runs.

The Cardinals have a WHIP of 1.320 and have a FIP of 4.04 as a staff on the year. They sit at 25th in the league as a staff in total hits given up with 1,349. The St. Louis pitching staff have given up 711 runs so far this season while holding a team ERA of 4.29 (645 earned runs allowed). Their K/BB ratio sits at 7.50 (1,135 strikeouts against 438 free passes). They have conceded 156 home runs and they give up 4.73 runs per 9 innings (22nd in the league).

St. Louis has had relievers take the mound in 62 save opportunities and they have come away with 40 saves. They are ranked 13th in MLB holding a save rate of 64.5%, and they have dispatched 456 relievers to the mound so far this season. Their bullpen pitchers have come in 148 times in high leverage situations and on 148 occasions with runners on. St. Louis bullpen pitchers hold an inherited score rate of 33.0% out of their 206 inherited runners. With 152 save situations, the Cardinals have recorded 86 holds in addition to 22 blown saves.

In 12,186 innings on the diamond, the Cardinals have accumulated a defensive efficiency of 69.0% (22nd in the majors). The St. Louis Cardinals have turned 121 double plays and have a fielding percentage of .987 (13th in pro baseball). The Cardinals have racked up 1,465 assists, 75 errors and have accumulated 4,062 putouts on the season.

Mikolas (72-74 career record) is the owner of a 4.23 earned run average while surrendering 9.2 hits per 9 innings. He has a K/BB ratio of 3.65 and he has gone up against 5,174 batters thus far in his career. He has conceded a total of 584 ER's while holding a WHIP of 1.215 and a FIP of 4.2. During his MLB career, Mikolas has surrendered 1,266 base hits while he has tallied 888 K's in 1,242 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+125)

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