Minnesota Twins vs Philadelphia Phillies Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Philadelphia Phillies

Date: Friday, September 26, 2025

Location: Citizens Bank Park in Philadelphia, PA

TV: NBC Sports Philadelphia

Odds/Point Spread: Minnesota (+106) Philadelphia (-128)

Citizens Bank Park is the location where the Philadelphia Phillies (93-65) will go up against the Minnesota Twins (68-90) on Friday. The odds on this game have the Twins at +106 while the Phillies are sitting at -128. The over/under is set at 8. The expected starting pitchers are Joe Ryan and Taijuan Walker.

The Twins have accrued 244 doubles as a squad and have knocked 185 balls out of the park. Minnesota is slugging .397 and have struck out 1,325 times, while being walked on 488 occasions. As a team, the Minnesota Twins are recording 4.2 runs per contest, which ranks them 21st in baseball. They have amassed 632 RBI's as well as 1,264 base knocks for the season, while their average at the plate comes in at .239. They have accounted for 667 runs scored and hold an OBP of .311.

Get all of our MLB Betting Picks

The Twins have a team earned run average of 4.65 for the season (25th in MLB), and their staff has struck out 1,327 hitters. Twins pitchers have conceded 192 home runs and 768 runs in total (25th in the league). Their pitching staff has walked 454 opposing batters and their FIP sits at 4.15 as a team on the season. Minnesota has surrendered 1,391 base knocks (9.0 per 9 innings) in addition to 718 earned runs. Their strikeout to walk ratio sits at 2.92 and their pitching staff has a team WHIP of 1.33.

The Twins have dispatched 530 relievers to the mound so far this season. The relievers have inherited 165 base runners so far this season and 35.8% of those runners earned a run for their team. They have accumulated 28 saves for the year and have blown 24 of 52 chances to save the game. The Twins bullpen have a save percentage of 53.8% and have come into the game in 146 save situations. The relievers have earned 92 holds on the season (10th in baseball). Twins relief pitchers have entered the game with players on base 115 times and also have had 168 appearances in high leverage situations.

The Twins have turned 68.3% of balls in play into outs out of 12,519 innings on the diamond, which has them sitting 28th in pro baseball. The Milwaukee Brewers have 4,173 putouts thus far, in addition to 1,184 assists and 83 errors. Their fielding rate sits at .985 which puts them in 18th in baseball, and have earned 95 double plays.

Ryan has taken the ball for 636 innings and has earned 710 strikeouts thus far in his career. His ERA is 3.81 (269 ER's allowed) and his WHIP is 1.064. He has allowed 530 base hits (7.5 hits per 9 innings) with 147 free passes. Ryan (46-35 mark in his career) has earned a FIP of 3.75 while going up against 2,582 hitters during his time in the major leagues.

Philadelphia has knocked in 210 home runs over the course of the season as well as 747 RBIs. They have hit 267 doubles, while getting a free base 522 times and putting up 772 runs. The Philadelphia Phillies have an OBP of .330 in addition to a team batting average of .260 for the season. The Phillies have a team slugging % of .435 and they tally 4.89 runs per game (6th in MLB). They have struck out on 1,291 occasions (19th in the league) and have notched a total of 1,402 base knocks.

The Phillies have a team WHIP of 1.241 in addition to having a FIP of 3.72 as a squad for the season. Their strikeout to walk ratio sits at 9.20 (1,427 strikeouts vs 424 bases on balls). They are sitting at 19th in the league as a staff in total hits given up with 1,317. They have conceded 173 long balls and they concede 4.11 runs per 9 innings (8th in the league). The Philadelphia pitching staff have conceded 641 runs on the year while having an ERA of 3.85 (600 earned runs allowed).

With 156 save situations, the Phillies have amassed 81 holds and also 27 blown saves. Philadelphia has called on relievers to enter the contest in 72 save opportunities and they have come away with 45 saves. Their bullpen pitchers have stepped onto the hill 174 times in high leverage situations in addition to 103 occasions with base runners. Philadelphia bullpen pitchers hold an inherited score rate of 32.4% out of their 148 inherited runners. They rank 18th in baseball with a save percentage of 62.5%, and they have dispatched 493 bullpen pitchers to the mound on the season.

In 12,630 innings played, the Phillies have a defensive efficiency of 69.0% (22nd in pro baseball). The Philadelphia Phillies have turned 101 double plays and have a fielding percentage of .989 (5th in MLB). The Phillies have racked up 1,354 assists, 62 errors and have 4,210 putouts for the season.

Walker (77-71 career mark) has a 4.20 earned run average while surrendering 8.5 hits per 9 innings. His strikeout to walk ratio is 2.52 and he has gone up against 5,408 batters so far in his pro baseball career. He has surrendered 594 ER's while holding a WHIP of 1.286 and being the owner of a FIP of 4.1. During his MLB career, Walker has conceded 1,209 base knocks while accumulating 1,083 strikeouts in 1,274 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Minnesota (+106)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here