New York Mets vs Chicago Cubs Prediction, 9/25/2025 MLB Picks, Best Bets & Odds

Game: New York Mets vs Chicago Cubs

Date: Thursday, September 25, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: New York (+102) Chicago (-122)

Wrigley Field is the location where the Chicago Cubs (88-69) will take on the New York Mets (81-76) on Thursday. The moneyline on this game has New York at +102 and Chicago is at -122. The betting total is set at 8. The starting pitchers are Nolan McLean and Shota Imanaga.

As a squad, the New York Mets are putting up 4.8 runs per game, which puts them at 9th in the league. They have a total of 748 runs while holding a team on-base percentage of .327. The Mets have hit 256 doubles as a team and have knocked 218 balls out of the stadium. They have 729 runs batted in as well as 1,326 base knocks this season, and their average at the plate comes in at .251. New York has a slugging % of .430 and have been called out on strikes 1,281 times, while taking a walk on 544 occasions.

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The Mets are sitting with a team ERA of 4.00 so far this season (17th in the league), and the staff has rung up 1,350 hitters. Mets pitchers have yielded 143 home runs in addition to 690 runs in total (18th in MLB). Their pitching staff has walked 544 opposing hitters and their FIP is 3.88 as a squad this year. New York has surrendered 1,300 base hits (8.4 per 9 innings) and also 618 earned runs. Their strikeout to walk ratio is 2.48 and the pitching staff has earned a collective WHIP of 1.33.

The Mets have sent 520 relievers to the mound on the season. The relief pitchers have inherited 248 runners on the campaign and 34.3% of those players ended up crossing the plate. They have recorded 39 saves so far this season and have not converted 28 of their 67 save chances. The Mets relievers have compiled a save rate of 58.2% and have stepped onto the mound in 164 save situations. The relievers have accumulated 96 holds for the season (8th in baseball). Mets relief pitchers have entered the game with players on base 169 times in addition to having 184 appearances in high leverage situations.

The Mets have transformed 68.7% of balls in play into outs in their 12,510 innings, ranking them 24th in professional baseball. The Minnesota Twins have a tally of 4,170 putouts for the season, as well as 1,426 assists and 78 errors. Their fielding rate is currently at .986 which has them ranked 15th in the majors, and have a total of 117 double plays.

McLean (4-1 career mark) has a FIP of 1.26 while he has faced 165 batters in the majors. He has given up 29 base knocks (6.2 hits per 9 innings) with 14 walks. His earned run average is 1.28 (6 earned runs allowed) and his WHIP is 1.019. McLean has taken the ball for 42 frames and has tallied 46 punch outs so far in his career.

The Cubs have a slugging percentage of .425 and they tally 4.82 runs per contest (8th in the league). They have 259 two-baggers, while getting a free base 541 times as well as earning 757 runs. Chicago has 209 home runs over the course of the season to go along with 737 runs batted in. They have been rung up on 1,233 occasions (25th in MLB) and have notched a total of 1,325 hits. The Chicago Cubs have tallied an OBP of .320 and a team batting average of .249 over the course of the season.

The Chicago pitching staff have conceded 634 runs so far this season while having an ERA of 3.82 (590 earned runs allowed). They have given up 196 home runs and they surrender 4.11 runs per 9 innings (6th in MLB). The Cubs are sitting with a team WHIP of 1.186 with a FIP of 4.20 as a squad on the season. Their strikeout to walk ratio comes in at 7.90 (1,214 strikeouts against 396 walks). They come in at 10th in the league as a pitching staff in total hits conceded with 1,252.

Chicago has called on relievers to step onto the hill in 62 save chances and they have recorded 42 saves. They rank 5th in baseball with a save percentage of 67.7%, and they have dispatched 509 relief pitchers onto the diamond this year. Their relievers have come in 157 times in high leverage situations and also on 98 occasions with runners on. Chicago bullpen pitchers have an inherited score rate of 34.1% of 138 inherited base runners. With 171 save situations, the Cubs have recorded 106 holds in addition to 20 blown saves.

The Chicago Cubs have turned 116 double plays and own a fielding percentage of .989 (5th in MLB). The Cubs have 1,306 assists, 60 errors and have 4,170 putouts this season. Out of their 12,510 innings played, the Cubs have earned a defensive efficiency of 71.8% (3rd in the majors).

In his career, Imanaga has surrendered 257 hits while he has accumulated 288 strikeouts in 312 innings pitched. Imanaga (24-10 win-loss mark in his career) has earned a 3.11 earned run average while surrendering 7.4 hits per nine innings. He has given up 108 earned runs while earning a WHIP of 0.993 and having a FIP of 3.1. His K/BB ratio is 5.43 and he has faced 1,235 opposing batters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-122) and under 8 runs

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