New York Yankees vs Baltimore Orioles Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Baltimore Orioles

Date: Sunday, September 21, 2025

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: New York (-150) Baltimore (+125)

The Baltimore Orioles (72-81) are hosting the New York Yankees (86-67) at Oriole Park at Camden Yards on Sunday. The odds on this game have New York at -150 while Baltimore is priced at +125. The over/under comes in at 9. The expected starting pitchers are Carlos Rodon and Tomoyuki Sugano.

As a team, the New York Yankees are knocking in 5.2 runs per game, which ranks them 1st in baseball. They have racked up 801 runs while having a team OBP of .331. The Yankees have accounted for 247 two-baggers as a squad and have hit 258 balls out of the park. They have tallied 773 RBI's as well as 1,296 base knocks on the campaign, and their team batting average is at .250. New York has a slugging % of .455 and have been rung up 1,370 times, while drawing a walk on 597 occasions.

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They have a strikeout to walk ratio of 2.56 and their pitching staff has earned a collective WHIP of 1.27. Yankees pitchers have yielded 166 long balls and also 666 total runs (16th in the league). New York has given up 1,192 hits (7.9 per 9 innings) and 608 earned runs. The Yankees have a team earned run average of 4.03 for the season (18th in MLB), and the staff has struck out 1,358 hitters. Their pitching staff has walked 530 opposing hitters and their FIP is 4.03 as a squad for the year.

Yankees pitchers have gone to the mound with runners on base 160 times and also have had 156 appearances in high leverage situations. The bullpen have 95 holds so far this season (7th in MLB). The Yankees bullpen have accumulated a save rate of 66.1% and have entered the game in 159 save situations. They have recorded 41 saves for the season and have blown 21 of 62 chances to save the game. The relief pitchers have inherited 245 base runners so far this season and 28.2% of them crossed the plate. The Yankees have dispatched 503 relievers to the mound so far this season.

The New York Mets have 4,049 putouts at this point in the season, as well as 1,316 assists and 88 errors. Their fielding rate sits at .984 which has them ranked 24th in MLB, and they have turned 104 double plays. The Yankees have turned 70.3% of balls hit into play into outs in their 12,147 innings on the diamond, which ranks them 12th in MLB.

Rodon (91-72 career record) sits with a FIP of 3.69 and he has faced 5,328 hitters in the major leagues. He has given up 1,077 hits (7.6 hits per 9 innings) with 475 walks. His earned run average is 3.75 (528 ER's allowed) and he has a career WHIP of 1.224. Rodon has taken the ball for 1,268 frames and has tallied 1,396 strikeouts during his pro baseball career.

The Orioles hold a team slugging % of .398 and they are recording 4.25 runs per outing (23rd in baseball). They have recorded 243 doubles, while walking 451 times as well as putting up 650 runs. Baltimore has 180 home runs so far this year to go along with 617 runs batted in. They have been called out on strikes on 1,369 occasions (4th in baseball) and have earned a total of 1,224 hits. The Baltimore Orioles have accumulated a team on-base percentage of .307 and a team batting average of .238 on the season.

The Baltimore pitching staff have relinquished 745 runs this season while holding an ERA of 4.61 (693 earned runs allowed). They have yielded 202 home runs and they allow 4.95 runs per 9 innings (24th in baseball). The Orioles have a WHIP of 1.371 in addition to having a FIP of 4.41 as a team this year. Their K/BB ratio sits at 8.40 (1,264 strikeouts vs 496 walks). They are sitting at 28th in the league as a staff in total hits allowed with 1,359.

Baltimore relief pitchers hold an inherited score rate of 26.2% out of 206 inherited base runners. Their relievers have come in 163 times in high leverage situations and on 148 occasions with runners on. Sitting with 164 save situations, the Orioles have compiled 103 holds and 20 blown saves. They rank 10th in MLB with a save rate of 64.9%, and they have dispatched 512 bullpen pitchers to the hill for the year. Baltimore has had bullpen pitchers step onto the hill in 57 save opportunities and they have converted 37 saves.

The Baltimore Orioles have gotten 113 double plays and have a fielding percentage of .985 (19th in the majors). The Orioles have recorded 1,336 assists, 83 errors and have accounted for 4,034 putouts for the year. Out of their 12,102 innings on the field, the Orioles have a efficiency on defense of 68.5% (26th in the majors).

In his career, Sugano has surrendered 162 hits while tallying 100 strikeouts in 149 frames. Sugano (10-8 career win-loss record) is the owner of a 4.40 earned run average and has surrendered 9.8 hits per nine innings. He has surrendered a total of 73 ER's while holding a WHIP of 1.320 and being the owner of a FIP of 4.3. He has a strikeout to walk ratio of 2.86 and he has faced 640 hitters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (+125)

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