Philadelphia Phillies vs Arizona Diamondbacks Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: Philadelphia Phillies vs Arizona Diamondbacks

Date: Friday, September 19, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Philadelphia (-145) Arizona (+125)

The Philadelphia Phillies (91-62) are traveling to Chase Field on Friday where they will attempt to defeat the Arizona Diamondbacks (77-76). The moneyline on this matchup has Philadelphia at -145 and Arizona is coming in at +125. The over/under has been set at 8. The pitchers who are expected to start are Walker Buehler and Ryne Nelson.

The Phillies have tallied 255 doubles as a team and have hit 197 baseballs out of the park. Philadelphia has a slugging rate of .431 and have been called out on strikes 1,245 times, while being walked on 504 occasions. As a team, the Philadelphia Phillies are knocking in 4.9 runs per contest, which has them at 8th in MLB. They have tallied 718 runs batted in as well as 1,350 base knocks this season, while their team batting average is sitting at .259. They have accounted for 743 runs scored while having a team OBP of .330.

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The Phillies have a team ERA of 3.86 on the campaign (10th in MLB), and they have rung up 1,389 batters. Phillies pitchers have yielded 167 home runs and also 619 runs in total (7th in MLB). Their pitching staff has walked 415 players from the other team and their FIP is 3.73 as a unit for the year. Philadelphia has allowed 1,269 base hits (8.4 per 9 innings) and 582 earned runs. They have a strikeout to walk ratio of 3.35 and the pitching staff has earned a collective WHIP of 1.24.

The Phillies have dispatched 476 relievers to the mound this year. The relief pitchers have inherited 143 runners on the campaign with 32.9% of those players earned a run for their team. They have 45 saves this season and have blown 26 of 71 save chances. The Phillies relievers have accumulated a save percentage of 63.4% and have come into the game in 152 save situations. The relievers have notched 78 holds on the year (22nd in MLB). Phillies bullpen pitchers have entered the game with runners on 98 times in addition to having 168 appearances in high leverage situations.

The Philadelphia Phillies have amassed 4,075 putouts so far this season, as well as 1,305 assists and 56 errors. Their fielding percentage sits at .990 which has them sitting 3rd in baseball, and have accumulated 98 double plays. The Phillies have converted 69.1% of balls in play into outs in their 12,225 innings, which has them ranked 21st in the majors.

Buehler (55-29 career win-loss record) sits with a FIP of 3.50 while he has gone up against 3,432 opposing hitters in the major leagues. He has given up 713 hits (7.7 hits per 9 innings) and has 246 walks. His earned run average is 3.56 (328 earned runs allowed) and his WHIP is 1.155. Buehler has taken the ball for 830 innings and has 841 punch outs so far in his MLB career.

The Arizona Diamondbacks have recorded an OBP of .324 in addition to a batting average of .251 on the year. They have been called out on strikes on 1,235 instances (23rd in MLB) and have earned 1,297 hits. Arizona has knocked in 205 HRs so far this season and 737 RBIs. The Diamondbacks hold a slugging percentage of .434 and they have an average of 4.95 runs per contest (5th in the league). They have tallied 260 doubles, while walking 513 times and earning 758 runs.

The Arizona pitching staff have conceded 731 runs for the year while having an ERA of 4.44 (673 earned runs conceded). They have conceded 181 dingers and they allow 4.82 runs per 9 innings (23rd in baseball). The Diamondbacks have a WHIP of 1.309 in addition to having a FIP of 4.26 as a unit over the course of the season. They currently have a K/BB ratio of 8.00 (1,209 strikeouts against 470 bases on balls). They are currently ranked 24th in MLB as a pitching staff in total hits conceded with 1,315.

With 161 save situations, the Diamondbacks have 86 holds and 29 blown saves. Arizona has had bullpen pitchers take the mound in 70 save chances and they have recorded 41 saves. Their relievers have stepped onto the mound 158 times in high leverage situations and also on 140 occasions with runners on. Arizona relievers have an inherited score rate of 34.1% out of their 185 inherited base runners. They are ranked 22nd in MLB with a save rate of 58.6%, and they have dispatched 470 bullpen pitchers to the mound for the year.

The Arizona Diamondbacks have turned 123 double plays and have a fielding percentage of .986 (15th in pro baseball). The Diamondbacks have recorded 1,376 assists, 77 errors and have amassed 4,092 putouts for the season. In 12,276 innings on the diamond, the Diamondbacks are sitting with a defensive efficiency of 69.7% (20th in baseball).

During his MLB career, Nelson has surrendered 435 base knocks while totaling 360 K's in 456 innings pitched. He has allowed 212 ER's while holding a WHIP of 1.228 and having a FIP of 4.1. His strikeout to walk ratio is 2.88 and he has gone up against 1,890 batters so far in his MLB career. Nelson (26-18 career mark) holds a 4.18 ERA while allowing 8.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Philadelphia (-145)

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