Philadelphia Phillies vs Arizona Diamondbacks Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Philadelphia Phillies vs Arizona Diamondbacks

Date: Sunday, September 21, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Philadelphia (-152) Arizona (+126)

Chase Field is the location where the Arizona Diamondbacks (77-76) will go up against the Philadelphia Phillies (91-62) on Sunday. The line on this matchup has the Phillies at -152 while the Diamondbacks are sitting at +126. The over/under is 8.5. The expected starting pitchers are Taijuan Walker and Zac Gallen.

Philadelphia owns a slugging percentage of .431 and have struck out 1,245 times, while taking a walk on 504 occasions. They have 718 RBI's in addition to 1,350 hits for the season, and their batting average comes in at .259. The Phillies have accrued 255 doubles as a team and have smacked 197 balls out of the park. They have tallied 743 runs and hold an OBP of .330. As a squad, the Philadelphia Phillies are scoring 4.9 runs per game, which has them sitting at 8th in baseball.

Get all of our MLB Expert Picks

Their strikeout to walk ratio is 3.35 and their pitching staff sits with a WHIP of 1.24. Phillies pitchers have conceded 167 home runs and 619 runs in total (7th in baseball). Philadelphia has given up 1,269 base knocks (8.4 per 9 innings) as well as 582 earned runs. The Phillies have a team ERA of 3.86 on the season (11th in MLB), and the staff has struck out 1,389 batters. Their pitching staff has walked 415 players from the other team and their FIP comes in at 3.72 as a squad this year.

Phillies bullpen pitchers have entered the contest with players on base 98 times and also have had 168 appearances in high leverage situations. The relief pitchers have accumulated 78 holds for the year (22nd in the league). The Phillies relief pitchers have a save percentage of 63.4% and have stepped onto the mound in 152 save situations. They have earned 45 saves so far this season and have blown 26 of 71 save opportunities. The relief pitchers have inherited 143 base runners on the season with 32.9% of those players crossed home plate. The Phillies have dispatched 476 relievers to the mound on the season.

The Phillies have turned 69.1% of balls in play into outs in their 12,225 innings, which has them sitting at 21st in baseball. The Philadelphia Phillies have notched a total of 4,075 putouts so far this season, in addition to 1,305 assists and 56 errors. Their fielding percentage is currently at .990 which puts them in 3rd in baseball, and they have turned 98 double plays.

Walker has taken the ball for 1,270 frames and has accounted for 1,081 K's during his MLB career. His ERA is 4.19 (592 ER's allowed) and he has a WHIP of 1.286. He has given up 1,204 base knocks (8.5 hits per 9 innings) with 429 free passes. Walker (77-71 career win-loss mark) has a FIP of 4.13 and he has gone up against 5,391 batters during his time in the majors.

Arizona has tallied 205 home runs this season to go along with 737 RBIs. They have recorded 260 doubles, while getting a free base 513 times and notching 758 runs. The Arizona Diamondbacks hold an on-base percentage of .324 in addition to a team batting average of .251 on the year. The Diamondbacks hold a team SLG% of .434 and they are earning 4.95 runs per contest (4th in the league). They have struck out on 1,235 occasions (23rd in the league) and have earned 1,297 base hits.

The Diamondbacks hold a team WHIP of 1.309 in addition to having a FIP of 4.26 as a pitching staff so far this season. They have a ranking of 24th in the league as a pitching staff in total hits conceded with 1,315. The Arizona pitching staff have surrendered 731 runs for the season while having a team ERA of 4.44 (673 earned runs allowed). They currently have a strikeout to walk ratio of 8.00 (1,209 strikeouts vs 470 walks). They have given up 181 home runs and they give up 4.82 runs per 9 innings (23rd in MLB).

Arizona has had relief pitchers enter the contest in 70 save chances and they have walked away with 41 saves. They sit at 22nd in MLB holding a save rate of 58.6%, and they have sent 470 relief pitchers to the mound for the season. Their bullpen pitchers have come in 158 times in high leverage situations and on 140 occasions with runners on base. Arizona relievers have an inherited score percentage of 34.1% of 185 inherited runners. With 161 save situations, the Diamondbacks have accrued 86 holds and also 29 blown saves.

The Arizona Diamondbacks have turned 123 double plays and have a fielding percentage of .986 (15th in pro baseball). The Diamondbacks have recorded 1,376 assists, 77 errors and have accounted for 4,092 putouts so far this season. In their 12,276 innings on the diamond, the Diamondbacks hold a defensive efficiency of 69.7% (20th in pro baseball).

In his pro baseball career, Gallen has given up 832 hits while tallying 1,048 punch outs in 995 frames. Gallen (65-51 career mark) holds a 3.55 ERA while giving up 7.5 hits per nine innings. He has allowed a total of 393 earned runs while holding a WHIP of 1.156 and a FIP of 3.5. He has a K/BB ratio of 3.29 and he has faced 4,090 hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Philadelphia (-152)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here