Pittsburgh Pirates vs Baltimore Orioles Prediction, 9/10/2025 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Baltimore Orioles

Date: Wednesday, September 10, 2025

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Pittsburgh (+102) Baltimore (-122)

The Baltimore Orioles (66-77) are welcoming the Pittsburgh Pirates (64-80) at Oriole Park at Camden Yards on Wednesday. The line on this matchup has Pittsburgh at +102 while Baltimore is sitting at -122. The over/under is 9. The men taking the mound are Paul Skenes and Tyler Wells.

The Pirates have accrued 218 two-baggers as a unit and have knocked 102 balls out of the stadium. Pittsburgh owns a slugging percentage of .351 and have struck out 1,257 times, while drawing a walk on 470 occasions. As a team, the Pittsburgh Pirates are compiling 3.6 runs per contest, which puts them at 30th in MLB. They have accounted for 502 runs batted in and 1,111 base knocks over the course of the season, and their batting average sits at .233. They have a total of 522 runs scored while holding a team on-base percentage of .306.

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They have a strikeout to walk ratio of 2.73 and their pitching staff has recorded a WHIP of 1.23. Pirates pitchers have allowed 137 home runs and also 591 total runs (9th in the league). Pittsburgh has allowed 1,139 hits (8.1 per 9 innings) as well as 552 earned runs. The Pirates are sitting with a team ERA of 3.91 this season (14th in the league), and they have struck out 1,141 hitters. Their pitching staff has walked 418 opposing batters and their FIP comes in at 3.90 as a team over the course of the season.

Pirates bullpen pitchers have entered the contest with players on base 123 times and also have had 134 appearances in high leverage situations. The relievers have accumulated 64 holds for the season (26th in the league). The Pirates bullpen have accumulated a save rate of 60.0% and stepped onto the hill in 121 save situations. They have compiled 33 saves for the year and have blown 22 of their 55 save opportunities. The relief pitchers have inherited 191 runners on the season with 36.6% of them ended up crossing the plate. The Pirates have sent 449 relievers to the mound for the year.

The Pittsburgh Pirates have amassed 3,812 putouts this season, in addition to 1,203 assists and 70 errors. Their fielding rate sits at .986 which puts them in 14th in professional baseball, and have a total of 106 double plays. The Pirates have converted 70.6% of balls in play into outs out of 11,436 innings on the field, which has them ranked 7th in baseball.

Skenes has taken the mound for 306 innings and has accounted for 365 strikeouts during his career. Skenes (21-12 career mark) has a FIP of 1.94 while he has faced 1,189 opposing batters in the major leagues. His ERA is 1.97 (67 earned runs allowed) and his WHIP is 0.941. He has surrendered 217 base hits (6.4 hits per nine innings) with 71 walks.

The Orioles hold a slugging % of .403 and they are scoring 4.34 runs per contest (17th in MLB). They have notched 232 two-baggers, while walking 410 times and putting up 620 runs. Baltimore has accumulated 172 HRs on the season to go along with 587 RBIs. They have struck out on 1,265 occasions (7th in the league) and have totaled 1,157 base hits. The Baltimore Orioles hold a team on-base percentage of .307 in addition to a batting average of .241 so far this season.

The Orioles are sitting with a team WHIP of 1.377 and are the owners of a FIP of 4.48 as a staff on the campaign. They currently have a K/BB ratio of 8.30 (1,171 strikeouts vs 458 bases on balls). They come in at 28th in the league as a staff in total hits allowed with 1,281. They have given up 194 homers and they surrender 5.00 runs per 9 innings (25th in MLB). The Baltimore pitching staff have allowed 702 runs over the course of the season while having a team ERA of 4.65 (653 earned runs surrendered).

Baltimore has had relief pitchers step onto the hill in 51 save opportunities and they have recorded 33 saves. They are ranked 11th in baseball with a save percentage of 64.7%, and they have dispatched 478 relievers onto the diamond for the year. Their relievers have come in 145 times in high leverage situations in addition to 138 occasions with runners on base. Baltimore relievers hold an inherited score percentage of 25.8% of 194 inherited base runners. With 148 save situations, the Orioles have recorded 93 holds and also 18 blown saves.

The Baltimore Orioles have turned 104 double plays and own a fielding percentage of .985 (21st in professional baseball). The Orioles have racked up 1,263 assists, 79 errors and have amassed 3,789 putouts so far this year. In 11,367 innings played, the Orioles are sitting with a defensive efficiency of 68.4% (27th in pro baseball).

Wells (17-18 career mark) has a 4.06 ERA and has conceded 7.1 hits per nine innings. He has a K/BB ratio of 3.57 and he has gone up against 1,204 opposing batters during his MLB career. He has surrendered 135 ER's while earning a WHIP of 1.046 and a FIP of 4.0. Thus far in his career, Wells has conceded 236 base hits while tallying 275 strikeouts in 299 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Baltimore (-122)

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