San Diego Padres vs Arizona Diamondbacks Prediction, 8/4/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Arizona Diamondbacks

Date: Monday, August 4, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: San Diego (-130) Arizona (+110)

The San Diego Padres (60-49) are hitting the road to Chase Field on Monday where they will go up against the Arizona Diamondbacks (51-58). The odds on this game have San Diego at -130 while Arizona is sitting at +110. The betting total is set at 8.5. The starting pitchers are JP Sears and Brandon Pfaadt.

As a unit, the San Diego Padres are notching 4.1 runs per game, which ranks them 24th in baseball. They have earned 445 runs scored while holding a team OBP of .318. The Padres have recorded 168 two-baggers as a team and have knocked 92 baseballs out of the park. They have amassed 417 runs batted in as well as 911 hits for the season, and their batting average is .250. San Diego is slugging .380 and have struck out 767 times, while being walked on 344 occasions.

Get all of our MLB Parlay Picks

They have accumulated a K/BB ratio of 2.57 and the pitching staff sits with a WHIP of 1.22. Padres pitchers have yielded 106 home runs and also 413 total runs (3rd in MLB). San Diego has relinquished 812 base hits (7.6 per 9 innings) in addition to 379 earned runs. The Padres are sitting with a team ERA of 3.55 over the course of the season (3rd in MLB), and they have struck out 921 batters. Their pitching staff has walked 358 opposing batters and their FIP is 3.87 as a squad on the campaign.

Padres relief pitchers have come into the game with players on base 129 times as well as having 156 appearances in high leverage situations. The relief pitchers have recorded 75 holds on the campaign (5th in baseball). The Padres relief pitchers have accumulated a save rate of 73.5% and have come into the game in 127 save situations. They have compiled 36 saves over the course of the season and have blown 13 of their 49 save chances. The relief pitchers have inherited 181 runners on the season and 28.7% of those runners crossed home plate. The Padres have dispatched 382 relievers to the mound so far this season.

The San Diego Padres have a total of 2,886 putouts this year, as well as 828 assists and 52 errors. Their fielding percentage is holding steady at .986 which ranks 13th in the majors, and have 80 double plays. The Padres have turned 71.5% of balls in play into outs out of their 8,658 innings on the field, which has them sitting 3rd in baseball.

Sears (29-39 career record) sits with a FIP of 4.42 and he has faced 2,253 batters during his time in the majors. He has given up 516 hits (8.7 hits per 9 innings) with 154 free passes. His earned run average is 4.48 (266 ER's allowed) and his WHIP is 1.255. Sears has thrown 534 frames and is sitting with 446 strikeouts during his pro baseball career.

Arizona has tallied 149 home runs over the course of the season to go along with 516 runs batted in. They have notched 191 doubles, while taking a walk 377 times and scoring 528 runs. The Arizona Diamondbacks are sitting with an on-base percentage of .323 as well as a batting average of .248 over the course of the season. The Diamondbacks have a SLG% of .436 and they are recording 4.84 runs per game (5th in baseball). They have been rung up on 861 instances (21st in baseball) and have tallied 914 base hits.

The Diamondbacks have a team WHIP of 1.334 in addition to having a FIP of 4.30 as a unit this year. They come in at 24th in MLB as a pitching staff in total hits given up with 949. The Arizona pitching staff have conceded 540 runs over the course of the season while holding an ERA of 4.60 (494 earned runs yielded). They have earned a strikeout to walk ratio of 8.40 (905 strikeouts against 341 walks). They have surrendered 139 homers and they surrender 5.02 runs per 9 innings (25th in MLB).

Arizona has called on bullpen pitchers to step onto the mound in 47 save opportunities and they have earned 29 saves. They sit at 16th in the league with a save rate of 61.7%, and they have dispatched 324 bullpen pitchers to the hill so far this season. Their bullpen pitchers have stepped onto the mound 94 times in high leverage situations in addition to 85 occasions with runners on. Arizona relief pitchers have an inherited score rate of 34.9% out of their 109 inherited base runners. Sitting with 103 save situations, the Diamondbacks have accumulated 53 holds and also 18 blown saves.

The Arizona Diamondbacks have turned 85 double plays and have a fielding percentage of .986 (18th in professional baseball). The Diamondbacks have racked up 957 assists, 56 errors and have accounted for 2,903 putouts over the course of the season. In 8,709 innings played, the Diamondbacks have a defensive efficiency of 69.0% (22nd in baseball).

Pfaadt (24-26 career win-loss record) is the owner of a 5.08 ERA and has allowed 9.6 hits per 9 innings. He has a strikeout to walk ratio of 4.05 and he has faced 1,686 opposing batters so far in his MLB career. He has allowed 222 ER's while holding a WHIP of 1.302 and having a FIP of 5.0. So far in his MLB career, Pfaadt has allowed 419 hits while he has tallied 377 K's in 393 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Arizona (+110) and under 8.5 runs

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here