San Diego Padres vs Arizona Diamondbacks Prediction, 8/6/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Arizona Diamondbacks

Date: Wednesday, August 6, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: San Diego (-160) Arizona (+132)

The San Diego Padres (62-51) are hitting the road to Chase Field on Wednesday where they will go up against the Arizona Diamondbacks (54-59). The odds on this game have San Diego at -160 while Arizona is at +132. The betting total is set at 9. The pitchers who are expected to start are Nestor Cortes and Anthony DeSclafani.

San Diego owns a slugging percentage of .380 and have been rung up 791 times, while taking a walk on 356 occasions. They have recorded 434 runs batted in as well as 943 hits for the season, while their batting average sits at .250. The Padres have recorded 172 doubles as a unit and have smacked 95 baseballs out of the park. They have accumulated 463 runs while holding a team OBP of .318. As a squad, the San Diego Padres are putting up 4.1 runs per game, which has them at 25th in MLB.

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The Padres have a team ERA of 3.58 on the campaign (3rd in the league), and they have struck out 957 hitters. Padres pitchers have allowed 110 home runs in addition to 431 runs in total (3rd in MLB). They have walked 364 opposing hitters and their FIP comes in at 3.86 as a team so far this season. San Diego has conceded 846 hits (7.6 per 9 innings) as well as 397 earned runs. They have accrued a K/BB ratio of 2.63 and their pitching staff holds a WHIP of 1.21.

Padres relief pitchers have come into the game with players on base 131 times and also have had 158 appearances in high leverage situations. The relief pitchers have earned 78 holds so far this year (3rd in MLB). The Padres relief pitchers have accumulated a save percentage of 74.5% and stepped onto the hill in 132 save situations. They have tallied 38 saves so far this year and have blown 13 of their 51 chances to get a save. The relief pitchers have inherited 185 runners so far this season with 29.2% of those players ended up crossing the plate. The Padres have sent 395 relief pitchers to the hill so far this year.

The San Diego Padres have earned 2,991 putouts at this point in the season, as well as 857 assists and 53 errors. Their fielding rate is at .986 which has them ranked 14th in the majors, and they have turned 84 double plays. The Padres have turned 71.4% of baseballs in play into outs out of 8,973 innings, which ranks them 2nd in baseball.

Cortes Jr has taken the ball for 576 innings and has racked up 583 strikeouts so far in his MLB career. Cortes Jr (34-22 career mark) is the owner of a FIP of 3.82 and he has gone up against 2,371 opposing hitters during his time in the major leagues. His earned run average is 3.88 (248 ER's allowed) and he has a WHIP of 1.172. He has conceded 508 base knocks (7.9 hits per nine innings) with 167 free passes.

Arizona is sitting with 155 home runs so far this year and 536 RBIs. They have tallied 197 doubles, while taking a walk 394 times as well as racking up 548 runs. The Arizona Diamondbacks have an on-base percentage of .325 in addition to a team batting average of .250 for the year. The Diamondbacks have a SLG% of .437 and they earn 4.85 runs per contest (6th in baseball). They have struck out on 886 instances (21st in baseball) and have 953 hits.

The Arizona pitching staff have conceded 553 runs for the season while holding a team ERA of 4.55 (507 earned runs conceded). They have surrendered 141 long balls and they yield 4.97 runs per 9 innings (25th in the league). The Diamondbacks hold a team WHIP of 1.334 with a FIP of 4.29 as a team for the season. They currently have a K/BB ratio of 8.30 (929 strikeouts vs 353 walks). They are sitting at 24th in MLB as a staff in total hits conceded with 984.

Arizona relief pitchers hold an inherited score percentage of 33.0% out of 115 inherited runners. Their relief pitchers have stepped onto the hill 97 times in high leverage situations and on 90 occasions with runners on base. Sitting with 109 save situations, the Diamondbacks have earned 57 holds and also 18 blown saves. They are ranked 15th in the league with a save rate of 63.3%, and they have sent 337 relief pitchers to the hill this season. Arizona has called on relief pitchers to step onto the hill in 49 save chances and they have converted 31 saves.

Out of their 9,024 innings on the field, the Diamondbacks have earned a defensive efficiency of 69.0% (23rd in professional baseball). The Arizona Diamondbacks have gotten 87 double plays and have a fielding percentage of .986 (17th in professional baseball). The Diamondbacks have accrued 996 assists, 57 errors and are sitting with 3,008 putouts this season.

In his pro baseball career, DeSclafani has allowed 968 base hits while earning 854 punch outs in 967 innings pitched. DeSclafani (55-58 mark in his career) is the owner of a 4.22 ERA while giving up 9.0 hits per nine innings. He has allowed 454 earned runs while earning a WHIP of 1.269 and being the owner of a FIP of 4.2. He has a strikeout to walk ratio of 3.28 and he has gone up against 4,077 hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Arizona (+132) and under 9 runs

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