San Diego Padres vs Chicago Cubs Prediction, 10/1/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago Cubs

Date: Wednesday, October 1, 2025

Location: Wrigley Field in Chicago, IL

TV: ABC

Odds/Point Spread: San Diego (+102) Chicago (-122)

The Chicago Cubs (92-70) are hosting the San Diego Padres (90-72) at Wrigley Field on Wednesday in Game 2 of the NL Wild Card series. The line on this contest has the Padres at +102 while the Cubs are coming in at -122. The betting total comes in at 9. The pitchers expected to start will be Dylan Cease and Shota Imanaga.

The Padres have accumulated 254 two-baggers as a unit and have hit 152 balls out of the park. San Diego has a slugging rate of .390 and have been rung up 1,161 times, while taking a walk on 510 occasions. As a unit, the San Diego Padres are putting up 4.3 runs per game, which ranks them 18th in the league. They have 663 RBI's as well as 1,369 base knocks for the year, while their average at the plate is .252. They have a total of 702 runs and hold an on-base percentage of .321.

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The Padres have a team earned run average of 3.63 this year (3rd in baseball), and their staff has rung up 1,425 hitters. Padres pitchers have conceded 178 long balls in addition to 621 runs in total (2nd in baseball). They have walked 535 players from the other team and their FIP is 4.02 as a team so far this season. San Diego has surrendered 1,197 base hits (7.5 per 9 innings) in addition to 578 earned runs. They have accumulated a K/BB ratio of 2.66 and their pitching staff has a team WHIP of 1.21.

The Padres have sent 577 relievers to the mound so far this season. The relievers have inherited 263 runners for the season and 29.3% of them ended up crossing the plate. They have tallied 49 saves so far this season and have blown 16 of their 65 save opportunities. The Padres relievers have earned a save rate of 75.4% and have come into the game in 174 save situations. The relievers have recorded 104 holds this season (7th in baseball). Padres bullpen pitchers have gone to the mound with runners on 185 times as well as having 209 appearances in high leverage situations.

The Padres have turned 71.7% of baseballs in play into outs in their 12,897 innings on the diamond, which ranks them 3rd in pro baseball. The San Diego Padres have accounted for 4,299 putouts this year, as well as 1,234 assists and 74 errors. Their fielding percentage sits at .987 which is 9th in the majors, and they have turned 117 double plays.

Cease (65-58 career record) sits with a FIP of 3.83 while he has faced 4,304 opposing batters in the major leagues. He has surrendered 854 hits (7.6 hits per nine innings) and has had 430 free passes. His earned run average is 3.88 (438 ER's allowed) and his career WHIP is 1.265. Cease has taken the ball for 1,015 frames and has accounted for 1,231 strikeouts so far in his MLB career.

Chicago has accounted for 223 home runs so far this season and 771 RBIs. They have tallied 267 two-baggers, while getting a free base 554 times and scoring 793 runs. The Chicago Cubs have a team OBP of .320 and a batting average of .249 for the season. The Cubs hold a slugging percentage of .430 and they score 4.90 runs per contest (5th in MLB). They have been called out on strikes on 1,277 occasions (25th in the league) and have earned 1,371 base hits.

The Chicago pitching staff have yielded 649 runs on the season while holding an ERA of 3.79 (605 earned runs conceded). They have allowed 202 home runs and they relinquish 4.07 runs per 9 innings (8th in the league). The Cubs hold a team WHIP of 1.177 and have a FIP of 4.16 as a unit this year. They have earned a K/BB ratio of 7.90 (1,265 strikeouts vs 405 bases on balls). They come in at 10th in the league as a staff in total hits relinquished with 1,284.

Chicago relievers hold an inherited score percentage of 33.8% of 142 inherited base runners. Their relievers have taken the field 158 times in high leverage situations and on 101 occasions with runners on. With 177 save situations, the Cubs have 110 holds in addition to 20 blown saves. They are currently ranked 4th in the league with a save rate of 68.8%, and they have dispatched 523 bullpen pitchers to the mound so far this season. Chicago has called on bullpen pitchers to enter the game in 64 save chances and they have walked away with 44 saves.

The Chicago Cubs have gotten 117 double plays and have earned a fielding percentage of .989 (4th in MLB). The Cubs have accrued 1,342 assists, 61 errors and have earned a total of 4,305 putouts this season. In 12,915 innings played, the Cubs have earned a defensive efficiency of 71.9% (2nd in the majors).

During his MLB career, Imanaga has allowed 266 base knocks and he has 291 strikeouts in 317 frames. He has given up a total of 116 earned runs while earning a WHIP of 1.009 and being the owner of a FIP of 3.2. He has a strikeout to walk ratio of 5.39 and he has gone up against 1,261 batters during his pro baseball career. Imanaga (24-11 career mark) has earned a 3.29 earned run average and has allowed 7.5 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-122)

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