San Diego Padres vs Chicago Cubs Prediction, 10/2/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago Cubs

Date: Thursday, October 2, 2025

Location: Wrigley Field in Chicago, IL

TV: ABC

Odds/Point Spread: San Diego (+150) Chicago (-182)

The Chicago Cubs (92-70) are hosting the San Diego Padres (90-72) at Wrigley Field on Wednesday in Game 2 of the NL Wild Card series. The moneyline on this contest has the Padres at +150 and the Cubs are sitting at -182. The over/under is 9. The pitchers taking the mound will be Yu Darvish and Jameson Taillon.

As a team, the San Diego Padres are scoring 4.3 runs per game, which has them sitting at 18th in MLB. They have racked up 702 runs while holding a team on-base percentage of .321. The Padres have hit 254 two-baggers as a team and have knocked 152 baseballs out of the park. They have compiled 663 RBI's in addition to 1,369 base knocks on the campaign, while their batting average is sitting at .252. San Diego has a slugging percentage of .390 and have been called out on strikes 1,161 times, while being walked on 510 occasions.

Get all of our MLB Betting Picks

The Padres have a team ERA of 3.63 on the campaign (3rd in MLB), and their staff has struck out 1,425 batters. Padres pitchers have given up 178 home runs and 621 runs in total (2nd in the league). Their pitching staff has walked 535 opposing batters and their FIP sits at 4.02 as a team for the year. San Diego has given up 1,197 base hits (7.5 per 9 innings) in addition to 578 earned runs. Their K/BB ratio is 2.66 and the pitching staff has recorded a WHIP of 1.21.

Padres bullpen pitchers have come into the game with opponents on base 185 times and also have had 209 appearances in high leverage situations. The relievers have racked up 104 holds this season (7th in the league). The Padres relief pitchers have earned a save percentage of 75.4% and have entered the game in 174 save situations. They have accumulated 49 saves this season and have blown 16 of 65 chances to save the game. The relievers have inherited 263 base runners on the season and 29.3% of them ended up crossing the plate. The Padres have sent 577 relievers to the mound over the course of the season.

The Padres have turned 71.7% of balls hit into play into outs out of 12,897 innings, ranking them 3rd in professional baseball. The San Diego Padres have amassed 4,299 putouts so far this season, in addition to 1,234 assists and 74 errors. Their fielding rate is holding steady at .987 which has them sitting 9th in professional baseball, and have a total of 117 double plays.

Darvish has taken the ball for 1,778 frames and is sitting with 2,075 K's during his MLB career. Darvish (115-93 career mark) has a FIP of 3.59 while going up against 7,305 hitters during his time in the major leagues. His ERA is 3.65 (721 earned runs allowed) and his WHIP is 1.138. He has surrendered 1,460 hits (7.4 hits per nine innings) and has 563 walks.

Chicago has hit 223 home runs so far this season as well as 771 RBIs. They have recorded 267 doubles, while taking a walk 554 times and racking up 793 runs. The Chicago Cubs have recorded an OBP of .320 as well as a team batting average of .249 for the year. The Cubs have a slugging percentage of .430 and they score 4.90 runs per outing (5th in MLB). They have been called out on strikes on 1,277 instances (25th in the league) and have tallied 1,371 base hits.

The Cubs hold a team WHIP of 1.177 with a FIP of 4.16 as a pitching staff for the season. They currently have a strikeout to walk ratio of 7.90 (1,265 strikeouts vs 405 bases on balls). They come in at 10th in MLB as a staff in total hits given up with 1,284. They have given up 202 HR's and they allow 4.07 runs per 9 innings (8th in the league). The Chicago pitching staff have conceded 649 runs so far this year while having an ERA of 3.79 (605 earned runs yielded).

Sitting with 177 save situations, the Cubs have recorded 110 holds and also 20 blown saves. Chicago has called on relief pitchers to enter the game in 64 save opportunities and they have earned 44 saves. Their relief pitchers have taken the field 158 times in high leverage situations in addition to 101 occasions with runners on base. Chicago bullpen pitchers hold an inherited score percentage of 33.8% out of their 142 inherited base runners. They are ranked 4th in the league with a save percentage of 68.8%, and they have sent 523 relief pitchers to the mound so far this season.

The Chicago Cubs have gotten 117 double plays and have earned a fielding percentage of .989 (4th in professional baseball). The Cubs have recorded 1,342 assists, 61 errors and have 4,305 putouts on the campaign. Out of their 12,915 innings on the diamond, the Cubs are sitting with a efficiency on defense of 71.9% (2nd in professional baseball).

So far in his pro baseball career, Taillon has surrendered 1,182 base knocks while accumulating 1,073 strikeouts in 1,236 innings pitched. Taillon (82-60 career record) is the owner of a 3.87 ERA while allowing 8.6 hits per 9 innings. He has allowed 532 earned runs while holding a WHIP of 1.194 and a FIP of 3.8. He has a K/BB ratio of 3.65 and he has gone up against 5,128 opposing batters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-182)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here