San Diego Padres vs Chicago Cubs Prediction, 4/4/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago Cubs

Date: Friday, April 4, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: San Diego (-150) Chicago (+125)

The Chicago Cubs (5-4) host the San Diego Padres (7-0) at Wrigley Field on Friday. The odds on this game have San Diego at -150 while Chicago is coming in at +125. The betting total comes in at 8.5. The pitchers who are expected to start will be Randy Vasquez and Shota Imanaga.

The Padres have accounted for 13 doubles as a unit and have hit 6 balls out of the park. San Diego has a slugging % of .440 and have struck out 40 times, while drawing a walk on 26 occasions. As a squad, the San Diego Padres are scoring 5.1 runs per game, which puts them at 8th in the league. They have compiled 33 runs batted in and 65 base knocks on the year, and their team batting average is at .298. They are sitting with 36 runs and hold an OBP of .369.

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They have earned a strikeout to walk ratio of 3.29 and the pitching staff has recorded a WHIP of 0.90. Padres pitchers have surrendered 5 home runs and 11 total runs (1st in the league). San Diego has surrendered 36 base hits (5.1 per 9 innings) in addition to 11 earned runs. The Padres are sitting with a team ERA of 1.57 this year (1st in baseball), and their staff has struck out 69 batters. Their pitching staff has walked 21 hitters and their FIP is 2.81 as a unit for the year.

The Padres have dispatched 26 relief pitchers to the mound so far this year. The bullpen pitchers have inherited 9 runners on the year and 0.0% of them earned a run for their team. They have earned 4 saves on the campaign and have blown 0 of their 4 chances to save the game. The Padres relief pitchers have a save percentage of 100.0% and has entered the game in 10 save situations. The relievers have accumulated 6 holds this year (8th in MLB). Padres relief pitchers have gone to the mound with runners on 6 times as well as having 8 appearances in high leverage situations.

The San Diego Padres have accounted for 189 putouts so far this season, in addition to 52 assists and 2 errors. Their fielding percentage is holding at .992 which puts them in 8th in MLB, and have accumulated 6 double plays. The Padres have converted 77.7% of balls in play into outs out of their 567 innings, which has them sitting 4th in the majors.

Vasquez has thrown 141 innings and has accounted for 98 K's in his MLB career. His earned run average is 4.14 (65 ER's allowed) and his WHIP is 1.445. He has allowed 153 hits (9.8 hits per nine innings) with 51 walks. Vasquez (6-9 career mark) sits with a FIP of 4.08 while he has gone up against 620 hitters during his time in the majors.

The Chicago Cubs have earned an on-base percentage of .344 as well as a batting average of .255 this year. They have struck out on 79 instances (1st in the league) and have recorded 84 hits. Chicago has accounted for 14 HRs on the year and 60 RBIs. The Cubs hold a team slugging percentage of .450 and they have an average of 6.67 runs per outing (3rd in baseball). They have 20 doubles, while taking a walk 43 times as well as putting up 60 runs.

The Chicago pitching staff have allowed 46 runs on the campaign while having an ERA of 5.13 (45 earned runs conceded). They have surrendered 12 dingers and they concede 5.24 runs per 9 innings (24th in the league). The Cubs have a WHIP of 1.544 and have a FIP of 4.83 as a team so far this year. Their strikeout to walk ratio comes in at 7.10 (62 strikeouts against 39 walks). They come in at 30th in MLB as a pitching staff in total hits given up with 83.

Sitting with 11 save situations, the Cubs have compiled 7 holds and also 1 blown save. Chicago has called on relief pitchers to step onto the hill in 4 save chances and they have walked away with 3 saves. Their relief pitchers have taken the field 2 times in high leverage situations and on 5 occasions with runners on. Chicago bullpen pitchers have an inherited score rate of 57.1% out of 7 inherited base runners. They rank 12th in baseball holding a save percentage of 75.0%, and they have dispatched 28 relievers onto the field for the season.

The Chicago Cubs have turned 10 double plays and have accounted for a fielding rate of .988 (12th in baseball). The Cubs have racked up 82 assists, 4 errors and have a tally of 237 putouts over the course of the season. In their 711 innings on the field, the Cubs hold a defensive efficiency of 68.8% (24th in pro baseball).

Imanaga (16-3 career record) is the owner of a 2.79 earned run average while allowing 7.4 hits per 9 innings. His strikeout to walk ratio is 5.29 and he has faced 736 opposing hitters in his career. He has allowed a total of 57 earned runs while earning a WHIP of 1.010 and having a FIP of 2.7. During his MLB career, Imanaga has given up 152 base knocks while tallying 180 K's in 184 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (+125) and under 8.5 runs

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