San Diego Padres vs Chicago White Sox Prediction, 9/20/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago White Sox

Date: Saturday, September 20, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: San Diego (-132) Chicago (+110)

Rate Field is the site where the Chicago White Sox (57-96) will attempt to defeat the San Diego Padres (83-69) on Saturday. The moneyline on this game has the Padres at -132 while the White Sox are sitting at +110. The total is set at 9. The starting pitchers will be Yu Darvish and Yoendrys Gomez.

San Diego has a slugging rate of .390 and have been called out on strikes 1,075 times, while drawing a walk on 484 occasions. They have accrued 614 runs batted in in addition to 1,281 base knocks for the season, while their average at the plate is .252. The Padres have tallied 244 two-baggers as a team and have hit 140 balls out of the park. They are sitting with 651 runs scored and have an on-base percentage of .322. As a team, the San Diego Padres are notching 4.3 runs per outing, which has them sitting at 20th in the league.

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The Padres hold a team earned run average of 3.67 on the year (3rd in MLB), and they have struck out 1,332 batters. Padres pitchers have surrendered 169 home runs and 590 runs in total (2nd in MLB). Their pitching staff has walked 488 opposing hitters and their FIP comes in at 4.03 as a squad this year. San Diego has surrendered 1,128 hits (7.6 per 9 innings) and also 548 earned runs. Their strikeout to walk ratio is 2.73 and the pitching staff has a collective WHIP of 1.20.

Padres bullpen pitchers have entered the contest with runners on 173 times and also have had 198 appearances in high leverage situations. The bullpen have a total of 98 holds over the course of the season (6th in MLB). The Padres bullpen have earned a save percentage of 74.6% and stepped onto the hill in 166 save situations. They have earned 47 saves on the campaign and have blown 16 of their 63 chances to save the game. The relievers have inherited 244 base runners on the season with 29.1% of them crossed the plate. The Padres have dispatched 536 relief pitchers to the hill over the course of the season.

The Padres have converted 71.7% of balls hit into play into outs out of their 12,087 innings on the field, which has them sitting 2nd in baseball. The San Diego Padres have a total of 4,029 putouts at this point in the season, as well as 1,143 assists and 70 errors. Their fielding percentage is holding at .987 which ranks 12th in MLB, and they have turned 107 double plays.

Darvish has taken the mound for 1,768 frames and is sitting with 2,067 strikeouts so far in his career. Darvish (114-93 record in his career) has earned a FIP of 3.59 while he has faced 7,266 batters in the major leagues. His ERA is 3.65 (717 earned runs allowed) and his WHIP is 1.136. He has allowed 1,448 hits (7.4 hits per nine innings) and has had 561 free passes.

The Chicago White Sox have a team on-base percentage of .302 in addition to a team batting average of .233 this season. They have struck out on 1,287 instances (14th in baseball) and have totaled 1,184 base knocks. Chicago is sitting with 154 home runs over the course of the season and 588 RBIs. The White Sox have a SLG% of .373 and they are recording 3.98 runs per game (26th in baseball). They have put up 231 two-baggers, while taking a walk 472 times and scoring 609 runs.

The Chicago pitching staff have allowed 698 runs this year while holding an ERA of 4.23 (629 earned runs relinquished). They have allowed 175 home runs and they surrender 4.69 runs per 9 innings (21st in MLB). The White Sox have a WHIP of 1.362 and have a FIP of 4.49 as a unit so far this season. They currently have a strikeout to walk ratio of 8.00 (1,193 strikeouts against 566 free passes). They come in at 15th in the league as a staff in total hits relinquished with 1,256.

Chicago has had bullpen pitchers enter the game in 44 save opportunities and they have recorded 23 saves. They rank 29th in the league with a save rate of 52.3%, and they have sent 498 relievers to the hill so far this season. Their bullpen pitchers have come in 141 times in high leverage situations in addition to 154 occasions with runners on. Chicago bullpen pitchers have an inherited score percentage of 31.8% out of 223 inherited runners. With 110 save situations, the White Sox have compiled 64 holds and also 21 blown saves.

The Chicago White Sox have gotten 123 double plays and have a fielding rate of .982 (28th in baseball). The White Sox have recorded 1,208 assists, 96 errors and have notched a total of 4,015 putouts on the campaign. In their 12,045 innings played, the White Sox hold a defensive efficiency of 69.8% (18th in the majors).

So far in his MLB career, Gomez has allowed 58 base hits while he has earned 63 punch outs in 64 innings. He has given up 33 ER's while earning a WHIP of 1.433 and having a FIP of 4.6. His K/BB ratio is 1.85 and he has faced 293 hitters in his pro baseball career. Gomez (3-2 record in his career) is the owner of a 4.63 ERA while giving up 8.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-132)

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