San Diego Padres vs Chicago White Sox Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago White Sox

Date: Sunday, September 21, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: San Diego (-145) Chicago (+125)

Rate Field is where the Chicago White Sox (57-96) will compete against the San Diego Padres (83-70) on Sunday. The moneyline on this contest has San Diego at -145 and Chicago is opening at +125. The over/under has been set at 8. The expected starting pitchers will be Yu Darvish and Yoendrys Gomez.

San Diego is slugging .389 and have been rung up 1,085 times, while being walked on 484 occasions. They have recorded 615 RBI's and 1,288 base knocks over the course of the season, and their average at the plate is at .252. The Padres have accounted for 244 doubles as a squad and have hit 140 baseballs out of the stadium. They have accounted for 652 runs scored while holding a team on-base percentage of .321. As a team, the San Diego Padres are notching 4.3 runs/g, which has them at 22nd in MLB.

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Their K/BB ratio is 2.73 and the pitching staff has recorded a WHIP of 1.20. Padres pitchers have surrendered 171 home runs in addition to 596 runs in total (3rd in MLB). San Diego has conceded 1,135 base hits (7.6 per 9 innings) in addition to 554 earned runs. The Padres have a team ERA of 3.69 this season (3rd in the league), and their staff has rung up 1,341 batters. Their pitching staff has walked 492 hitters and their FIP is 4.04 as a unit this year.

The Padres have dispatched 541 relief pitchers to the mound so far this season. The bullpen pitchers have inherited 246 base runners on the season with 29.7% of those runners crossed home plate. They have accumulated 47 saves over the course of the season and have blown 16 of their 63 chances to get a save. The Padres relievers have recorded a save percentage of 74.6% and have come into the game in 166 save situations. The relief pitchers have notched 98 holds on the season (6th in MLB). Padres relief pitchers have gone to the mound with runners on 174 times and also have had 199 appearances in high leverage situations.

The San Diego Padres have accumulated 4,029 putouts over the course of the season, in addition to 1,143 assists and 70 errors. Their fielding percentage is at .987 which ranks 12th in MLB, and have accumulated 107 double plays. The Padres have converted 71.7% of balls hit into play into outs out of 12,087 innings on the diamond, which ranks them 2nd in professional baseball.

Darvish has thrown 1,768 frames and is sitting with 2,067 strikeouts in his MLB career. His earned run average is 3.65 (717 earned runs allowed) and his WHIP is 1.136. He has given up 1,448 base hits (7.4 hits per nine innings) and has 561 walks. Darvish (114-93 career record) holds a FIP of 3.59 while going up against 7,266 opposing hitters in the major leagues.

Chicago has compiled 154 home runs on the campaign as well as 588 RBIs. They have recorded 231 two-baggers, while taking a walk 472 times and putting up 609 runs. The Chicago White Sox hold an OBP of .302 and a batting average of .233 this season. The White Sox have a team slugging % of .373 and they earn 3.98 runs per game (26th in the league). They have struck out on 1,287 occasions (14th in the league) and have recorded 1,184 base hits.

The White Sox have a WHIP of 1.362 and are the owners of a FIP of 4.49 as a staff this season. They are currently ranked 15th in MLB as a staff in total hits surrendered with 1,256. The Chicago pitching staff have yielded 698 runs this season while having a team ERA of 4.23 (629 earned runs given up). Their K/BB ratio sits at 8.00 (1,193 strikeouts vs 566 walks). They have relinquished 175 dingers and they relinquish 4.69 runs per 9 innings (21st in baseball).

Chicago has called on bullpen pitchers to enter the game in 44 save opportunities and they have tallied 23 saves. They are currently ranked 29th in the league with a save rate of 52.3%, and they have dispatched 498 relievers to the mound for the season. Their relief pitchers have come in 141 times in high leverage situations in addition to 154 occasions with runners on. Chicago relievers hold an inherited score percentage of 31.8% out of their 223 inherited runners. Sitting with 110 save situations, the White Sox have earned 64 holds and also 21 blown saves.

The Chicago White Sox have turned 123 double plays and have a fielding rate of .982 (28th in professional baseball). The White Sox have accrued 1,208 assists, 96 errors and have notched a total of 4,015 putouts so far this season. Out of their 12,045 innings played, the White Sox hold a defensive efficiency of 69.8% (18th in baseball).

Gomez (3-2 career win-loss mark) has earned a 4.63 ERA and has conceded 8.1 hits per nine innings. His strikeout to walk ratio is 1.85 and he has gone up against 293 opposing batters so far in his MLB career. He has allowed a total of 33 ER's while earning a WHIP of 1.433 and being the owner of a FIP of 4.6. In his MLB career, Gomez has given up 58 hits while he has accumulated 63 punch outs in 64 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-145)

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