San Diego Padres vs Miami Marlins Prediction, 7/22/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Miami Marlins

Date: Tuesday, July 22, 2025

Location: loanDepot park in Miami, FL

TV: FanDuel Sports Network Florida

Odds/Point Spread: San Diego (-144) Miami (+120)

loanDepot park is the site where the Miami Marlins (46-52) will play the San Diego Padres (54-45) on Tuesday. The odds on this game have San Diego at -144 while Miami is sitting at +120. The total comes in at 8.5. The pitchers taking the mound will be Stephen Kolek and Edward Cabrera.

San Diego has a slugging % of .377 and have been rung up 695 times, while being walked on 322 occasions. They have accrued 375 RBI's in addition to 811 base knocks so far this season, while their team batting average comes in at .247. The Padres have accrued 144 doubles as a team and have hit 86 balls out of the stadium. They are sitting with 400 runs scored while holding a team OBP of .317. As a squad, the San Diego Padres are compiling 4.0 runs per game, which is 24th in the league.

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They have earned a strikeout to walk ratio of 2.57 and the pitching staff has a team WHIP of 1.23. Padres pitchers have conceded 98 home runs and also 383 runs in total (4th in baseball). San Diego has surrendered 748 hits (7.7 per 9 innings) as well as 351 earned runs. The Padres hold a team ERA of 3.61 so far this season (5th in baseball), and they have struck out 849 batters. Their pitching staff has walked 330 players from the other team and their FIP is 3.87 as a team so far this year.

The Padres have sent 349 relievers to the hill so far this year. The relief pitchers have inherited 164 base runners for the season with 31.1% of those players crossed home plate. They have accumulated 34 saves this year and have missed out on 12 of their 46 save opportunities. The Padres relief pitchers have compiled a save rate of 73.9% and stepped onto the hill in 116 save situations. The relievers have notched 68 holds this year (6th in MLB). Padres pitchers have entered the game with runners on base 118 times in addition to having 144 appearances in high leverage situations.

The San Diego Padres have a tally of 2,550 putouts on the campaign, as well as 724 assists and 48 errors. Their fielding percentage is holding at .986 which is 20th in the majors, and have 65 double plays. The Padres have converted 71.1% of balls in play into outs out of their 7,650 innings, which has them ranked 7th in professional baseball.

Kolek (6-4 win-loss mark in his career) has a FIP of 4.58 while he has gone up against 498 opposing hitters in the majors. He has given up 125 base knocks (9.9 hits per 9 innings) and has 34 walks. His ERA is 4.65 (59 earned runs allowed) and he has a WHIP of 1.392. Kolek has taken the mound for 114 innings and has accumulated 88 K's during his pro baseball career.

The Marlins hold a team SLG% of .392 and they are recording 4.32 runs per contest (17th in MLB). They have recorded 165 two-baggers, while taking a walk 292 times and notching 423 runs. Miami is sitting with 90 HRs this year as well as 407 runs batted in. They have struck out on 777 occasions (24th in the league) and have 849 hits. The Miami Marlins have an on-base percentage of .315 as well as a batting average of .253 over the course of the season.

The Marlins are sitting with a team WHIP of 1.324 in addition to having a FIP of 4.16 as a staff over the course of the season. Their strikeout to walk ratio is 7.90 (769 strikeouts against 312 walks). They are sitting at 23rd in baseball as a staff in total hits conceded with 844. They have allowed 108 long balls and they yield 4.93 runs per 9 innings (24th in the league). The Miami pitching staff have allowed 478 runs for the season while having an ERA of 4.57 (443 earned runs allowed).

Miami has had bullpen pitchers step onto the hill in 39 save opportunities and they have recorded 23 saves. They are ranked 20th in the league with a save rate of 59.0%, and they have dispatched 312 bullpen pitchers to the hill for the season. Their bullpen pitchers have come in 108 times in high leverage situations and also on 80 occasions with runners on base. Miami relief pitchers hold an inherited score percentage of 31.3% out of their 115 inherited base runners. Sitting with 93 save situations, the Marlins have amassed 53 holds in addition to 16 blown saves.

The Miami Marlins have gotten 65 double plays and hold a fielding percentage of .986 (18th in professional baseball). The Marlins have 831 assists, 48 errors and have accounted for 2,535 putouts so far this year. In 7,605 innings played, the Marlins are sitting with a defensive efficiency of 69.2% (20th in MLB).

So far in his MLB career, Cabrera has given up 302 hits while he has accumulated 414 strikeouts in 376 innings pitched. Cabrera (20-26 mark in his career) holds a 4.16 ERA while giving up 7.2 hits per 9 innings. He has surrendered 174 earned runs while earning a WHIP of 1.329 and being the owner of a FIP of 4.1. He has a strikeout to walk ratio of 2.09 and he has faced 1,610 hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Miami (+120)

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