San Diego Padres vs Minnesota Twins Prediction, 8/31/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Minnesota Twins

Date: Sunday, August 31, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: San Diego (-275) Minnesota (+220)

The Minnesota Twins (60-73) are hosting the San Diego Padres (75-59) at Target Field on Sunday. The moneyline on this contest has San Diego at -275 while Minnesota is at +220. The betting total is set at 9. The starting pitchers are Randy Vasquez and Joe Ryan.

The Padres have tallied 219 two-baggers as a squad and have hit 116 balls out of the park. San Diego has a slugging percentage of .385 and have been called out on strikes 938 times, while drawing a walk on 430 occasions. As a squad, the San Diego Padres are putting up 4.2 runs per game, which ranks them 23rd in baseball. They have 529 RBI's in addition to 1,123 hits on the campaign, while their average at the plate sits at .251. They have earned a total of 564 runs and have an OBP of .321.

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Their strikeout to walk ratio is 2.63 and their pitching staff holds a collective WHIP of 1.19. Padres pitchers have allowed 139 home runs in addition to 510 total runs (2nd in baseball). San Diego has surrendered 977 hits (7.4 per 9 innings) and 473 earned runs. The Padres are sitting with a team earned run average of 3.60 for the season (2nd in MLB), and their staff has rung up 1,150 batters. Their pitching staff has walked 437 opposing hitters and their FIP is 3.95 as a team for the year.

Padres relief pitchers have entered the contest with runners on base 154 times as well as having 182 appearances in high leverage situations. The relievers have tallied 90 holds so far this year (4th in the league). The Padres bullpen have a save percentage of 74.1% and have come into the game in 153 save situations. They have earned 43 saves this season and have blown 15 out of their 58 chances to save the game. The relief pitchers have inherited 218 runners so far this season and 28.0% of those runners earned a run for their team. The Padres have dispatched 470 relievers to the mound on the campaign.

The San Diego Padres have accounted for 3,552 putouts on the campaign, in addition to 1,010 assists and 61 errors. Their fielding percentage sits at .987 which has them sitting 12th in MLB, and have accumulated 100 double plays. The Padres have converted 72.1% of baseballs in play into outs in their 10,656 innings on the diamond, which has them sitting 2nd in MLB.

Vasquez has taken the ball for 246 innings and has earned 154 strikeouts in his career. His ERA is 4.17 (114 ER's allowed) and he has a career WHIP of 1.421. He has given up 254 hits (9.3 hits per 9 innings) and has had 96 walks. Vasquez (9-15 career mark) is the owner of a FIP of 4.10 while he has gone up against 1,078 batters in the majors.

The Twins have a SLG% of .398 and they score 4.18 runs per game (24th in MLB). They have put up 204 doubles, while getting a free base 403 times and putting up 556 runs. Minnesota has accounted for 159 home runs over the course of the season to go along with 530 runs batted in. They have been called out on strikes on 1,105 occasions (16th in baseball) and have earned a total of 1,058 hits. The Minnesota Twins hold an OBP of .310 as well as a batting average of .238 over the course of the season.

The Twins have a team WHIP of 1.307 in addition to having a FIP of 4.07 as a unit for the season. Their strikeout to walk ratio comes in at 8.60 (1,113 strikeouts vs 368 bases on balls). They are sitting at 24th in the league as a staff in total hits relinquished with 1,161. They have surrendered 159 dingers and they yield 4.75 runs per 9 innings (23rd in the league). The Minnesota pitching staff have conceded 618 runs for the season while holding an ERA of 4.44 (577 earned runs yielded).

Sitting with 127 save situations, the Twins have amassed 81 holds in addition to 19 blown saves. Minnesota has had relief pitchers enter the contest in 44 save opportunities and they have walked away with 25 saves. Their relief pitchers have come in 155 times in high leverage situations and also on 100 occasions with runners on. Minnesota relievers hold an inherited score rate of 35.7% of 143 inherited base runners. They are ranked 25th in the league with a save percentage of 56.8%, and they have dispatched 454 relievers to the hill over the course of the season.

The Minnesota Twins have gotten 80 double plays and have a fielding rate of .987 (14th in baseball). The Twins have accrued 991 assists, 61 errors and have accounted for 3,510 putouts on the season. In their 10,530 innings on the field, the Twins have a efficiency on defense of 68.6% (27th in pro baseball).

Ryan (45-33 record in his career) holds a 3.76 earned run average while surrendering 7.4 hits per nine innings. He has a strikeout to walk ratio of 5.01 and he has gone up against 2,500 batters in his career. He has conceded 258 earned runs while earning a WHIP of 1.050 and a FIP of 3.7. During his career, Ryan has allowed 511 hits while totaling 691 K's in 618 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Minnesota (+220)

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