San Diego Padres vs New York Mets Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs New York Mets

Date: Tuesday, September 16, 2025

Location: Citi Field in Queens, NY

TV: Sportsnet New York

Odds/Point Spread: San Diego (-150) New York (+125)

The San Diego Padres (82-68) are hitting the road to Citi Field on Tuesday where they will meet the New York Mets (77-73). The moneyline on this game has San Diego at -150 and New York is sitting at +125. The total is 9. The pitchers taking the mound are Michael King and Clay Holmes.

San Diego has a slugging rate of .388 and have been called out on strikes 1,065 times, while drawing a walk on 478 occasions. They have accumulated 604 RBI's and 1,262 hits this season, and their average at the plate is .252. The Padres have tallied 242 two-baggers as a team and have smacked 135 baseballs out of the park. They have tallied 641 runs scored while holding a team OBP of .321. As a squad, the San Diego Padres are compiling 4.3 runs per game, which has them at 21st in baseball.

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The Padres have an ERA of 3.64 over the course of the season (3rd in MLB), and they have struck out 1,312 hitters. Padres pitchers have conceded 161 home runs and also 578 runs in total (2nd in baseball). They have walked 484 opposing hitters and their FIP sits at 3.98 as a unit so far this season. San Diego has yielded 1,109 hits (7.5 per 9 innings) as well as 536 earned runs. Their strikeout to walk ratio is 2.71 and their pitching staff has a collective WHIP of 1.20.

The Padres bullpen have a save percentage of 74.2% and have stepped onto the mound in 163 save situations. The relief pitchers have inherited 242 base runners this year with 29.3% of them ended up scoring. Padres relief pitchers have entered the contest with runners on base 171 times in addition to having 197 appearances in high leverage situations. The Padres have dispatched 529 relief pitchers to the mound on the year. The relief pitchers have racked up 96 holds over the course of the season (6th in the league). They have recorded 46 saves for the season and have blown 16 of 62 save opportunities.

The San Diego Padres have accumulated 3,978 putouts so far this season, as well as 1,132 assists and 70 errors. Their fielding percentage is at .986 which ranks 13th in pro baseball, and have accumulated 106 double plays. The Padres have turned 71.7% of balls in play into outs in their 11,934 innings, which has them ranked 2nd in baseball.

King has pitched in 483 innings and has racked up 550 K's so far in his MLB career. King (30-28 career record) has a FIP of 3.12 and he has gone up against 2,016 hitters during his time in the major leagues. His earned run average is 3.17 (170 ER's allowed) and his WHIP is 1.177. He has surrendered 403 base knocks (7.5 hits per nine innings) with 166 free passes.

The Mets hold a team slugging percentage of .426 and they score 4.69 runs per game (11th in the league). They have tallied 245 doubles, while walking 525 times and earning 704 runs. New York has a total of 203 HRs this season to go along with 686 runs batted in. They have been rung up on 1,219 occasions (19th in baseball) and have earned a total of 1,257 base hits. The New York Mets have an OBP of .327 as well as a team batting average of .249 this year.

The Mets have a team WHIP of 1.337 and have a FIP of 3.89 as a unit this season. They have a ranking of 18th in the league as a pitching staff in total hits given up with 1,243. The New York pitching staff have allowed 658 runs so far this season while having a team ERA of 4.01 (591 earned runs conceded). They have earned a strikeout to walk ratio of 8.70 (1,285 strikeouts against 528 free passes). They have given up 135 homers and they relinquish 4.47 runs per 9 innings (18th in MLB).

With 157 save situations, the Mets have recorded 92 holds in addition to 27 blown saves. New York has had relief pitchers step onto the mound in 65 save opportunities and they have come away with 38 saves. Their relief pitchers have come in 178 times in high leverage situations in addition to 161 occasions with base runners. New York bullpen pitchers have an inherited score percentage of 34.9% out of 241 inherited runners. They rank 23rd in MLB with a save percentage of 58.5%, and they have sent 490 relief pitchers to the hill this season.

The New York Mets have gotten 113 double plays and have accounted for a fielding rate of .987 (11th in the majors). The Mets have accrued 1,348 assists, 70 errors and have a tally of 3,975 putouts this season. In 11,925 innings played, the Mets have a defensive efficiency of 68.7% (25th in the majors).

In his pro baseball career, Holmes has given up 428 hits while he has earned 482 punch outs in 488 innings. Holmes (35-30 career mark) has a 3.72 ERA and has conceded 7.9 hits per nine innings. He has allowed a total of 202 earned runs while earning a WHIP of 1.317 and a FIP of 3.7. He has a K/BB ratio of 2.24 and he has gone up against 2,113 opposing hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take New York (+125)

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