San Diego Padres vs New York Yankees Prediction, 5/6/2025 MLB Picks, Best Bets & Odds
Game: San Diego Padres vs New York Yankees
Date: Tuesday, May 6, 2025
Location: Yankee Stadium in Bronx, NY
TV: YES
Odds/Point Spread: San Diego (-152) New York (+126)
The San Diego Padres (22-11) are en route to Yankee Stadium on Tuesday where they will attempt to beat the New York Yankees (19-15). The line on this matchup has San Diego at -152 and New York is coming in at +126. The total is set at 8.5. The expected starting pitchers are Michael King and Clarke Schmidt.


As a unit, the San Diego Padres are compiling 4.0 runs per game, which is 18th in the league. They have a total of 133 runs scored and hold an OBP of .329. The Padres have tallied 50 doubles as a unit and have knocked 29 baseballs out of the stadium. They have tallied 122 runs batted in in addition to 279 hits on the campaign, and their team batting average sits at .260. San Diego has a slugging % of .393 and have been rung up 226 times, while being walked on 106 occasions.
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They have a strikeout to walk ratio of 2.70 and their pitching staff holds a collective WHIP of 1.14. Padres pitchers have allowed 25 home runs and 95 total runs (1st in the league). San Diego has surrendered 225 hits (7.0 per 9 innings) and 89 earned runs. The Padres hold a team earned run average of 2.75 so far this year (1st in the league), and their staff has rung up 289 batters. They have walked 107 opposing players and their FIP comes in at 3.43 as a team for the season.
The Padres have dispatched 115 relief pitchers to the mound on the season. The relief pitchers have inherited 37 base runners this season with 27.0% of them crossed the plate. They have 14 saves over the course of the season and have blown 1 of their 15 save opportunities. The Padres relievers have a save percentage of 93.3% and have come into the game in 43 save situations. The bullpen have earned 27 holds this season (4th in the league). Padres relief pitchers have entered the contest with runners on 25 times and also have had 43 appearances in high leverage situations.
The San Diego Padres have a total of 873 putouts at this point in the season, as well as 239 assists and 15 errors. Their fielding percentage sits at .987 which has them sitting 13th in baseball, and have 23 double plays. The Padres have turned 72.5% of balls in play into outs out of their 2,619 innings, which has them ranked 4th in the majors.
King (30-27 career win-loss record) has earned a FIP of 3.07 and he has gone up against 1,917 batters in the majors. He has conceded 383 hits (7.5 hits per 9 innings) and has had 158 free passes. His ERA is 3.12 (159 earned runs allowed) and his WHIP is 1.178. King has pitched in 459 innings and has earned 529 K's during his MLB career.
The Yankees have a SLG% of .470 and they average 5.50 runs per game (2nd in the league). They have notched 59 doubles, while walking 135 times and scoring 187 runs. New York is sitting with 57 home runs so far this season to go along with 181 runs batted in. They have struck out on 308 occasions (5th in baseball) and have recorded 302 hits. The New York Yankees have compiled a team OBP of .346 in addition to a team batting average of .262 so far this year.
The Yankees hold a team WHIP of 1.205 in addition to having a FIP of 3.75 as a staff on the year. Their K/BB ratio sits at 9.40 (312 strikeouts vs 134 bases on balls). They are sitting at 1st in MLB as a pitching staff in total hits conceded with 225. They have conceded 31 long balls and they give up 4.08 runs per 9 innings (10th in the league). The New York pitching staff have allowed 135 runs this season and come in with a team ERA of 3.62 (120 earned runs allowed).
New York has called on relief pitchers to step onto the mound in 14 save chances and they have tallied 10 saves. They sit at 11th in MLB with a save rate of 71.4%, and they have dispatched 106 bullpen pitchers onto the field over the course of the season. Their relievers have taken the field 25 times in high leverage situations and on 35 occasions with base runners. New York relievers have an inherited score rate of 14.3% out of their 49 inherited base runners. Sitting with 35 save situations, the Yankees have amassed 21 holds in addition to 4 blown saves.
In 2,682 innings played, the Yankees have earned a efficiency on defense of 72.9% (2nd in the majors). The New York Yankees have gotten 20 double plays and have notched a fielding percentage of .984 (18th in MLB). The Yankees have recorded 286 assists, 19 errors and have earned 894 putouts this season.
Schmidt (19-21 mark in his career) has a 4.03 ERA and has conceded 8.7 hits per nine innings. His K/BB ratio is 2.76 and he has gone up against 1,419 batters during his career. He has given up a total of 147 earned runs while holding a WHIP of 1.322 and being the owner of a FIP of 4.0. In his MLB career, Schmidt has conceded 316 hits and he has 326 K's in 328 frames.
Who will win tonight's MLB game against the spread or moneyline?
Josh Schonwald's Pick: Take San Diego (-152)
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Additional Resources:
New York Yankees - Twitter
San Diego Padres - Twitter