San Diego Padres vs Seattle Mariners Prediction, 8/26/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Seattle Mariners

Date: Tuesday, August 26, 2025

Location: T-Mobile Park in Seattle, WA

TV: Root Sports Northwest

Odds/Point Spread: San Diego (-130) Seattle (+110)

The San Diego Padres (74-57) are traveling to T-Mobile Park on Tuesday where they will take on the Seattle Mariners (70-61). The moneyline on this matchup has San Diego at -130 and Seattle is opening at +110. The betting total comes in at 8. The starting pitchers will be Dylan Cease and Luis Castillo.

San Diego has a slugging percentage of .383 and have struck out 911 times, while drawing a walk on 424 occasions. They have accrued 513 runs batted in as well as 1,094 hits over the course of the season, while their batting average comes in at .251. The Padres have tallied 212 two-baggers as a team and have hit 111 baseballs out of the park. They have accumulated 548 runs while holding a team on-base percentage of .321. As a unit, the San Diego Padres are scoring 4.2 runs per outing, which puts them at 22nd in the league.

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The Padres have a team ERA of 3.53 so far this season (2nd in baseball), and the staff has rung up 1,127 batters. Padres pitchers have allowed 134 home runs and 491 total runs (2nd in the league). Their pitching staff has walked 427 opposing players and their FIP sits at 3.91 as a team for the season. San Diego has surrendered 952 hits (7.4 per 9 innings) and also 455 earned runs. They have earned a K/BB ratio of 2.64 and their pitching staff sits with a WHIP of 1.19.

Padres relief pitchers have entered the game with opponents on base 150 times and also have had 176 appearances in high leverage situations. The relievers have notched 88 holds on the campaign (5th in the league). The Padres bullpen have recorded a save percentage of 73.7% and have entered the game in 149 save situations. They have recorded 42 saves on the campaign and have missed out on 15 of their 57 chances to save the game. The bullpen pitchers have inherited 212 base runners so far this season with 27.4% of those players crossed the plate. The Padres have dispatched 458 relief pitchers to the hill on the year.

The Padres have transformed 72.1% of balls hit into play into outs out of 10,431 innings on the diamond, which has them sitting at 2nd in pro baseball. The San Diego Padres have accumulated 3,477 putouts this year, as well as 991 assists and 58 errors. Their fielding percentage is currently at .987 which ranks 10th in baseball, and have earned 99 double plays.

Cease (63-57 win-loss mark in his career) has earned a FIP of 3.83 and he has gone up against 4,174 opposing hitters during his time in the majors. He has given up 826 base hits (7.6 hits per 9 innings) and has 417 walks. His earned run average is 3.89 (425 ER's allowed) and he has a career WHIP of 1.263. Cease has thrown 984 innings and has tallied 1,194 punch outs during his career.

The Mariners hold a slugging % of .410 and they average 4.56 runs per contest (11th in MLB). They have recorded 179 two-baggers, while taking a walk 440 times and putting up 597 runs. Seattle has accumulated 186 home runs so far this year and 573 runs batted in. They have been rung up on 1,175 instances (3rd in the league) and are sitting with 1,075 base hits. The Seattle Mariners have compiled a team on-base percentage of .317 as well as a batting average of .241 this season.

The Mariners have a WHIP of 1.258 and have a FIP of 4.10 as a staff this year. Their K/BB ratio is 8.50 (1,119 strikeouts vs 397 bases on balls). They are sitting at 21st in the league as a staff in total hits relinquished with 1,091. They have yielded 157 dingers and they relinquish 4.37 runs per 9 innings (16th in MLB). The Seattle pitching staff have yielded 575 runs over the course of the season while having an ERA of 3.95 (519 earned runs surrendered).

Seattle relievers hold an inherited score percentage of 25.2% out of their 119 inherited runners. Their relief pitchers have stepped onto the mound 180 times in high leverage situations and on 110 occasions with base runners. With 125 save situations, the Mariners have 71 holds and also 20 blown saves. They sit at 16th in baseball holding a save percentage of 63.0%, and they have sent 440 relievers to the hill on the year. Seattle has called on relievers to take the mound in 54 save chances and they have tallied 34 saves.

The Seattle Mariners have gotten 95 double plays and have a fielding rate of .989 (5th in pro baseball). The Mariners have accrued 1,104 assists, 54 errors and are sitting with 3,550 putouts this year. In their 10,650 innings on the diamond, the Mariners have earned a efficiency on defense of 70.4% (10th in baseball).

Castillo (81-83 career record) holds a 3.56 earned run average and has surrendered 7.8 hits per 9 innings. He has a strikeout to walk ratio of 3.26 and he has faced 5,696 batters during his MLB career. He has given up a total of 544 ER's while holding a WHIP of 1.187 and having a FIP of 3.5. Thus far in his career, Castillo has given up 1,186 base knocks and he has 1,458 punch outs in 1,376 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-130)

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