San Francisco Giants vs Arizona Diamondbacks Prediction, 9/15/2025 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Arizona Diamondbacks

Date: Monday, September 15, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: San Francisco (-150) Arizona (+125)

Chase Field is where the Arizona Diamondbacks (73-74) will attempt to beat the San Francisco Giants (74-72) on Monday. The odds on this game have San Francisco at -150 while Arizona is sitting at +125. The over/under comes in at 8.5. The expected starting pitchers are Carson Whisenhunt and Zac Gallen.

As a unit, the San Francisco Giants are recording 4.4 runs per game, which puts them at 16th in MLB. They are sitting with 637 runs while holding a team on-base percentage of .314. The Giants have hit 217 two-baggers as a team and have hit 159 baseballs out of the park. They have tallied 608 RBI's as well as 1,161 hits on the campaign, and their team batting average is at .239. San Francisco has a slugging percentage of .392 and have struck out 1,236 times, while drawing a walk on 490 occasions.

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Their strikeout to walk ratio is 2.73 and the pitching staff has earned a collective WHIP of 1.29. Giants pitchers have given up 125 long balls in addition to 605 total runs (10th in baseball). San Francisco has surrendered 1,211 base knocks (8.4 per 9 innings) and 539 earned runs. The Giants have an ERA of 3.76 for the year (6th in MLB), and their staff has rung up 1,235 hitters. They have walked 453 opposing batters and their FIP is 3.68 as a unit over the course of the season.

The Giants relief pitchers have accumulated a save percentage of 65.5% and have stepped onto the mound in 134 save situations. The relievers have inherited 171 base runners on the campaign and 35.7% of them crossed home plate. Giants relief pitchers have gone to the mound with players on base 107 times as well as having 152 appearances in high leverage situations. The Giants have sent 462 relief pitchers to the mound this season. The relievers have a total of 79 holds for the year (18th in baseball). They have 36 saves so far this season and have blown 19 of 55 save chances.

The Seattle Mariners have a total of 3,875 putouts on the campaign, in addition to 1,364 assists and 86 errors. Their fielding percentage is holding at .984 which is 24th in the majors, and have accumulated 121 double plays. The Giants have converted 68.4% of baseballs in play into outs in their 11,625 innings on the diamond, ranking them 27th in MLB.

Whisenhunt has taken the hill for 23 innings and has accounted for 16 K's in his pro baseball career. His ERA is 5.06 (13 earned runs allowed) and his career WHIP is 1.472. He has given up 22 base hits (8.6 hits per nine innings) and has had 12 free passes. Whisenhunt (2-1 career win-loss record) sits with a FIP of 4.99 while he has gone up against 102 opposing hitters during his time in the major leagues.

The Diamondbacks have a team slugging percentage of .434 and they earn 4.93 runs per contest (6th in the league). They have recorded 246 two-baggers, while taking a walk 490 times and notching 724 runs. Arizona has 199 HRs on the year as well as 705 RBIs. They have struck out on 1,190 instances (21st in MLB) and have earned a total of 1,242 base hits. The Arizona Diamondbacks have accumulated an OBP of .323 as well as a team batting average of .250 this year.

The Diamondbacks have a WHIP of 1.320 and are the owners of a FIP of 4.26 as a staff for the season. Their strikeout to walk ratio is 8.00 (1,163 strikeouts against 455 bases on balls). They come in at 24th in the league as a staff in total hits conceded with 1,271. They have conceded 174 long balls and they relinquish 4.85 runs per 9 innings (23rd in the league). The Arizona pitching staff have surrendered 705 runs this season while having an ERA of 4.48 (650 earned runs conceded).

Arizona relievers have an inherited score percentage of 34.1% of 173 inherited runners. Their relief pitchers have taken the field 145 times in high leverage situations and on 132 occasions with runners on. With 152 save situations, the Diamondbacks have accumulated 81 holds in addition to 27 blown saves. They rank 22nd in baseball holding a save rate of 59.7%, and they have dispatched 447 relievers onto the field for the year. Arizona has called on bullpen pitchers to take the mound in 67 save chances and they have converted 40 saves.

The Arizona Diamondbacks have gotten 116 double plays and have accounted for a fielding rate of .986 (15th in pro baseball). The Diamondbacks have racked up 1,328 assists, 73 errors and have earned a total of 3,923 putouts for the year. In their 11,769 innings on the field, the Diamondbacks hold a defensive efficiency of 69.5% (20th in professional baseball).

Gallen (64-51 career mark) has a 3.57 ERA and has given up 7.6 hits per 9 innings. His K/BB ratio is 3.28 and he has gone up against 4,069 opposing batters thus far in his career. He has conceded 392 earned runs while holding a WHIP of 1.160 and being the owner of a FIP of 3.5. So far in his career, Gallen has surrendered 830 base hits while earning 1,042 strikeouts in 989 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Francisco (-150)

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