San Francisco Giants vs Los Angeles Dodgers Prediction, 9/18/2025 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Los Angeles Dodgers

Date: Thursday, September 18, 2025

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: San Francisco (+132) Los Angeles (-160)

The San Francisco Giants (75-76) are hitting the road to Dodger Stadium on Thursday where they will take on the Los Angeles Dodgers (84-67). The odds on this game have the Giants at +132 and the Dodgers are at -160. The total is set at 8.5. The pitchers who are expected to start are Logan Webb and Yoshinobu Yamamoto.

As a team, the San Francisco Giants are putting up 4.4 runs per game, which has them at 17th in MLB. They have tallied 657 runs scored while holding a team on-base percentage of .312. The Giants have compiled 224 doubles as a team and have hit 162 balls out of the park. They have amassed 627 RBI's as well as 1,187 base knocks on the campaign, and their team batting average comes in at .237. San Francisco is slugging .388 and have struck out 1,278 times, while being walked on 509 occasions.

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They have a strikeout to walk ratio of 2.65 and their pitching staff holds a collective WHIP of 1.31. Giants pitchers have allowed 129 home runs in addition to 643 runs in total (13th in baseball). San Francisco has surrendered 1,272 base hits (8.6 per 9 innings) and 575 earned runs. The Giants have an ERA of 3.87 this year (11th in baseball), and the staff has struck out 1,265 batters. They have walked 478 opposing hitters and their FIP is 3.73 as a squad on the campaign.

The Giants have dispatched 481 relievers to the hill for the year. The relief pitchers have inherited 181 base runners so far this season and 37.6% of them crossed the plate. They have compiled 36 saves on the campaign and have blown 19 of 55 save opportunities. The Giants relief pitchers have a save percentage of 65.5% and have entered the game in 134 save situations. The relievers have earned 79 holds for the season (19th in baseball). Giants bullpen pitchers have entered the contest with players on base 114 times and also have had 159 appearances in high leverage situations.

The Giants have turned 68.1% of baseballs in play into outs out of 12,021 innings on the field, which has them sitting 28th in MLB. The Seattle Mariners are sitting with 4,007 putouts at this point in the season, as well as 1,417 assists and 90 errors. Their fielding percentage is holding at .984 which ranks 25th in MLB, and they have turned 125 double plays.

Webb (69-52 career mark) is the owner of a FIP of 3.36 and he has faced 4,280 batters in the major leagues. He has allowed 1,005 base knocks (8.7 hits per 9 innings) and has 247 walks. His ERA is 3.41 (395 ER's allowed) and he has a WHIP of 1.200. Webb has taken the ball for 1,043 innings and has totaled 976 punch outs during his MLB career.

The Dodgers hold a slugging percentage of .440 and they are scoring 5.12 runs per contest (2nd in MLB). They have hit 242 doubles, while taking a walk 554 times as well as earning 773 runs. Los Angeles has 223 long balls this year to go along with 741 RBIs. They have been rung up on 1,260 occasions (15th in baseball) and have totaled 1,301 base knocks. The Los Angeles Dodgers have accumulated an on-base percentage of .330 as well as a team batting average of .254 on the campaign.

The Los Angeles pitching staff have relinquished 656 runs so far this year while having an ERA of 4.08 (607 earned runs surrendered). They have given up 171 dingers and they relinquish 4.41 runs per 9 innings (15th in the league). The Dodgers hold a team WHIP of 1.269 and have a FIP of 4.06 as a pitching staff this year. Their K/BB ratio sits at 9.20 (1,370 strikeouts vs 520 walks). They have a ranking of 6th in MLB as a staff in total hits conceded with 1,181.

Los Angeles relievers hold an inherited score percentage of 26.0% out of their 215 inherited runners. Their relief pitchers have stepped onto the mound 165 times in high leverage situations and on 138 occasions with runners on base. With 178 save situations, the Dodgers have recorded 110 holds and also 24 blown saves. They sit at 18th in the league with a save rate of 61.9%, and they have sent 536 relievers to the mound for the year. Los Angeles has had relief pitchers step onto the hill in 63 save chances and they have walked away with 39 saves.

The Los Angeles Dodgers have turned 97 double plays and hold a fielding percentage of .988 (6th in the majors). The Dodgers have recorded 1,269 assists, 64 errors and have 4,021 putouts so far this year. In 12,063 innings on the diamond, the Dodgers are sitting with a efficiency on defense of 70.4% (11th in professional baseball).

Yamamoto (18-10 mark in his career) has a 2.78 earned run average while surrendering 6.6 hits per 9 innings. He has a K/BB ratio of 4.00 and he has gone up against 1,006 opposing hitters during his pro baseball career. He has surrendered a total of 78 ER's while earning a WHIP of 1.027 and a FIP of 2.7. So far in his MLB career, Yamamoto has surrendered 186 hits while he has totaled 292 punch outs in 252 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-160)

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