Seattle Mariners vs Houston Astros Prediction, 5/22/2025 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Houston Astros

Date: Thursday, May 22, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Seattle (-122) Houston (+102)

Daikin Park is the location where the Houston Astros (25-23) will attempt to beat the Seattle Mariners (27-20) on Thursday. The odds on this game have Seattle at -122 and Houston is opening at +102. The over/under is set at 8.5. The pitchers taking the mound will be George Kirby and Lance McCullers Jr..

Seattle is slugging .397 and have been rung up 415 times, while taking a walk on 186 occasions. They have 213 RBI's and 375 base knocks so far this season, and their team batting average sits at .236. The Mariners have accumulated 62 two-baggers as a squad and have hit 63 baseballs out of the park. They have earned 221 runs and hold an OBP of .324. As a squad, the Seattle Mariners are notching 4.7 runs per contest, which has them at 9th in baseball.

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They have accumulated a K/BB ratio of 2.57 and the pitching staff has a collective WHIP of 1.30. Mariners pitchers have conceded 44 long balls and also 195 runs (13th in the league). Seattle has surrendered 406 base knocks (8.5 per 9 innings) as well as 172 earned runs. The Mariners hold a team earned run average of 3.61 this season (11th in the league), and the staff has struck out 388 hitters. Their pitching staff has walked 151 players from the other team and their FIP comes in at 3.75 as a unit so far this season.

The Mariners relievers have earned a save rate of 66.7% and have come into the game in 50 save situations. The relievers have inherited 44 base runners on the year and 27.3% of those runners earned a run for their team. Mariners bullpen pitchers have gone to the mound with runners on 39 times as well as having 67 appearances in high leverage situations. The Mariners have dispatched 166 relievers to the hill for the year. The relief pitchers have recorded 26 holds on the season (20th in the league). They have accumulated 16 saves for the season and have blown 8 of their 24 save chances.

The San Francisco Giants are sitting with 1,286 putouts over the course of the season, in addition to 417 assists and 19 errors. Their fielding percentage is holding at .989 which is 6th in professional baseball, and have earned 34 double plays. The Mariners have converted 69.5% of balls hit into play into outs out of 3,858 innings on the diamond, which has them sitting at 19th in MLB.

Kirby has taken the mound for 511 innings and is sitting with 484 K's during his pro baseball career. His ERA is 3.43 (195 ER's allowed) and his career WHIP is 1.094. He has given up 495 hits (8.7 hits per nine innings) with 64 walks. Kirby (35-26 career win-loss record) has earned a FIP of 3.38 and he has faced 2,077 hitters during his time in the majors.

The Astros have a SLG% of .375 and they have an average of 3.98 runs per outing (21st in MLB). They have recorded 69 two-baggers, while walking 152 times as well as racking up 191 runs. Houston has compiled 42 HRs for the year and 182 RBIs. They have been rung up on 371 occasions (24th in the league) and have totaled 392 base knocks. The Houston Astros have accumulated a team OBP of .318 in addition to a batting average of .247 this season.

The Astros hold a team WHIP of 1.121 and are the owners of a FIP of 3.45 as a unit this year. They come in at 3rd in MLB as a pitching staff in total hits given up with 327. The Houston pitching staff have surrendered 171 runs on the campaign and come in with a team ERA of 3.38 (158 earned runs yielded). They currently have a K/BB ratio of 9.30 (437 strikeouts against 145 walks). They have allowed 42 dingers and they allow 3.65 runs per 9 innings (6th in baseball).

Houston has called on relief pitchers to step onto the hill in 18 save opportunities and they have come away with 13 saves. They rank 4th in the league holding a save percentage of 72.2%, and they have sent 148 relief pitchers onto the diamond on the season. Their relief pitchers have stepped onto the hill 38 times in high leverage situations and on 34 occasions with runners on base. Houston bullpen pitchers have an inherited score percentage of 32.0% out of 50 inherited runners. With 47 save situations, the Astros have compiled 29 holds in addition to 5 blown saves.

The Houston Astros have turned 26 double plays and hold a fielding percentage of .988 (7th in the majors). The Astros have 357 assists, 19 errors and have accounted for 1,264 putouts this season. Out of their 3,792 innings on the diamond, the Astros have earned a defensive efficiency of 72.7% (3rd in MLB).

So far in his pro baseball career, McCullers has allowed 613 hits and he has 806 punch outs in 726 frames. He has given up 285 ER's while holding a WHIP of 1.261 and having a FIP of 3.5. His strikeout to walk ratio is 2.66 and he has faced 3,062 hitters so far in his career. McCullers (49-33 career win-loss mark) is the owner of a 3.53 ERA while allowing 7.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Seattle (-122)

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