Seattle Mariners vs Houston Astros Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Houston Astros

Date: Friday, September 19, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Seattle (+162) Houston (-196)

Daikin Park is where the Houston Astros (84-69) will play the Seattle Mariners (83-69) on Friday. The odds on this game have the Mariners at +162 while the Astros are priced at -196. The over/under is 8.5. The starting pitchers will be Bryan Woo and Hunter Brown.

The Mariners have recorded 219 two-baggers as a unit and have knocked 223 baseballs out of the park. Seattle has a slugging percentage of .420 and have struck out 1,341 times, while drawing a walk on 515 occasions. As a unit, the Seattle Mariners are putting up 4.8 runs per contest, which puts them at 10th in MLB. They have accrued 691 runs batted in and 1,266 base knocks this year, and their team batting average is at .245. They have 722 runs while holding a team OBP of .321.

Get all of our Free MLB Picks

The Mariners have compiled a team ERA of 3.94 over the course of the season (14th in the league), and the staff has rung up 1,326 batters. Mariners pitchers have relinquished 183 home runs and 666 total runs (17th in baseball). Their pitching staff has walked 438 batters and their FIP sits at 4.06 as a squad over the course of the season. Seattle has relinquished 1,266 hits (8.3 per 9 innings) and 601 earned runs. Their strikeout to walk ratio sits at 3.03 and the pitching staff has a collective WHIP of 1.24.

Mariners pitchers have entered the game with players on base 127 times and also have had 207 appearances in high leverage situations. The relief pitchers have a total of 85 holds so far this year (15th in MLB). The Mariners bullpen have recorded a save percentage of 61.5% and have entered the game in 150 save situations. They have 40 saves this season and have blown 25 of 65 save chances. The bullpen pitchers have inherited 138 runners this season and 25.4% of those runners crossed home plate. The Mariners have dispatched 517 relief pitchers to the mound for the season.

The Mariners have turned 70.1% of balls hit into play into outs out of their 12,354 innings on the diamond, which ranks them 14th in baseball. The San Francisco Giants have earned 4,118 putouts so far this season, in addition to 1,278 assists and 66 errors. Their fielding percentage sits at .988 which has them ranked 7th in MLB, and they have turned 111 double plays.

Woo has taken the ball for 390 innings and is sitting with 385 strikeouts in his career. His earned run average is 3.25 (141 ER's allowed) and his career WHIP is 0.989. He has surrendered 307 hits (7.1 hits per nine innings) and has 79 walks. Woo (27-15 win-loss record in his career) has earned a FIP of 3.20 and he has faced 1,557 hitters in the majors.

Houston has recorded 169 home runs this year as well as 622 runs batted in. They have hit 234 two-baggers, while walking 451 times and racking up 652 runs. The Houston Astros have an OBP of .318 as well as a batting average of .252 for the season. The Astros hold a slugging % of .400 and they have an average of 4.26 runs per contest (23rd in the league). They have been called out on strikes on 1,220 instances (24th in baseball) and have a total of 1,308 base hits.

The Astros have a team WHIP of 1.221 in addition to having a FIP of 4.00 as a unit on the year. They come in at 5th in baseball as a pitching staff in total hits given up with 1,185. The Houston pitching staff have surrendered 625 runs for the year while having a team ERA of 3.83 (581 earned runs surrendered). Their strikeout to walk ratio sits at 9.40 (1,428 strikeouts vs 480 free passes). They have allowed 185 long balls and they surrender 4.12 runs per 9 innings (7th in the league).

Houston has called on relievers to enter the game in 61 save opportunities and they have earned 45 saves. They are currently ranked 2nd in MLB with a save rate of 73.8%, and they have sent 488 relief pitchers to the hill so far this year. Their relievers have taken the field 166 times in high leverage situations and on 124 occasions with base runners. Houston relievers have an inherited score percentage of 22.7% out of their 172 inherited runners. Sitting with 152 save situations, the Astros have tallied 88 holds in addition to 16 blown saves.

In their 12,276 innings on the diamond, the Astros have earned a defensive efficiency of 70.7% (7th in pro baseball). The Houston Astros have turned 100 double plays and have earned a fielding percentage of .988 (8th in the majors). The Astros have accrued 1,207 assists, 66 errors and have accumulated 4,092 putouts on the campaign.

So far in his MLB career, Brown has conceded 450 base hits while earning 571 strikeouts in 520 innings pitched. Brown (36-29 career mark) holds a 3.46 earned run average and has conceded 7.8 hits per 9 innings. He has conceded a total of 200 ER's while earning a WHIP of 1.202 and having a FIP of 3.4. His K/BB ratio is 3.26 and he has gone up against 2,138 opposing batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Seattle (+162)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here