Seattle Mariners vs Houston Astros Prediction, 9/20/2025 MLB Picks, Best Bets & Odds

Game: Seattle Mariners vs Houston Astros

Date: Saturday, September 20, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Seattle (+220) Houston (-275)

The Houston Astros (84-69) will go up against the Seattle Mariners (83-69) at Daikin Park on Saturday. The odds on this game have the Mariners at +220 and the Astros are sitting at -275. The betting total is set at 8. The starting pitchers are George Kirby and Framber Valdez.

Seattle has a slugging percentage of .420 and have been rung up 1,341 times, while drawing a walk on 515 occasions. They have recorded 691 runs batted in in addition to 1,266 hits over the course of the season, and their team batting average sits at .245. The Mariners have compiled 219 doubles as a squad and have hit 223 baseballs out of the park. They have earned a total of 722 runs while holding a team OBP of .321. As a unit, the Seattle Mariners are knocking in 4.8 runs per game, which ranks them 10th in the league.

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The Mariners have an earned run average of 3.94 on the year (14th in MLB), and their staff has struck out 1,326 batters. Mariners pitchers have conceded 183 home runs and also 666 total runs (17th in the league). They have walked 438 players from the other team and their FIP is 4.06 as a team on the season. Seattle has given up 1,266 hits (8.3 per 9 innings) and also 601 earned runs. Their strikeout to walk ratio is 3.03 and the pitching staff has a collective WHIP of 1.24.

Mariners bullpen pitchers have come into the game with runners on 127 times as well as having 207 appearances in high leverage situations. The relievers have a total of 85 holds on the season (15th in MLB). The Mariners bullpen have compiled a save rate of 61.5% and have entered the game in 150 save situations. They have compiled 40 saves so far this year and have blown 25 out of their 65 save chances. The bullpen pitchers have inherited 138 runners over the course of the season with 25.4% of those players ended up crossing the plate. The Mariners have sent 517 relief pitchers to the mound for the season.

The Mariners have turned 70.1% of balls in play into outs out of their 12,354 innings on the field, ranking them 14th in pro baseball. The San Francisco Giants are sitting with 4,118 putouts on the year, in addition to 1,278 assists and 66 errors. Their fielding percentage is holding at .988 which puts them in 7th in baseball, and have accumulated 111 double plays.

Kirby (44-33 win-loss mark in his career) holds a FIP of 3.57 while going up against 2,559 opposing hitters during his time in the majors. He has surrendered 608 hits (8.7 hits per 9 innings) and has had 92 walks. His earned run average is 3.62 (252 earned runs allowed) and his WHIP is 1.118. Kirby has pitched in 626 frames and has earned 604 strikeouts during his pro baseball career.

The Astros hold a slugging % of .400 and they average 4.26 runs per game (23rd in baseball). They have put up 234 doubles, while walking 451 times as well as putting up 652 runs. Houston has accumulated 169 home runs over the course of the season as well as 622 RBIs. They have been rung up on 1,220 occasions (24th in MLB) and have earned a total of 1,308 base hits. The Houston Astros have accumulated an OBP of .318 in addition to a team batting average of .252 this season.

The Astros have a WHIP of 1.221 and have a FIP of 4.00 as a team this year. Their strikeout to walk ratio sits at 9.40 (1,428 strikeouts vs 480 walks). They are currently ranked 5th in the league as a staff in total hits relinquished with 1,185. They have given up 185 long balls and they allow 4.12 runs per 9 innings (7th in baseball). The Houston pitching staff have surrendered 625 runs for the year while holding a team ERA of 3.83 (581 earned runs relinquished).

Houston has had bullpen pitchers enter the game in 61 save opportunities and they have tallied 45 saves. They are currently ranked 2nd in MLB holding a save percentage of 73.8%, and they have sent 488 bullpen pitchers to the mound so far this year. Their bullpen pitchers have taken the field 166 times in high leverage situations and also on 124 occasions with runners on base. Houston bullpen pitchers hold an inherited score percentage of 22.7% of 172 inherited base runners. Sitting with 152 save situations, the Astros have earned 88 holds in addition to 16 blown saves.

In their 12,276 innings played, the Astros have a defensive efficiency of 70.7% (7th in MLB). The Houston Astros have gotten 100 double plays and hold a fielding percentage of .988 (8th in the majors). The Astros have racked up 1,207 assists, 66 errors and have a tally of 4,092 putouts for the year.

In his MLB career, Valdez has surrendered 899 base knocks while tallying 1,039 punch outs in 1,068 innings. He has given up 398 earned runs while earning a WHIP of 1.200 and being the owner of a FIP of 3.3. His strikeout to walk ratio is 2.71 and he has faced 4,429 hitters in his pro baseball career. Valdez (80-51 career mark) is the owner of a 3.35 earned run average and has given up 7.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Seattle (+220)

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