St. Louis Cardinals vs Baltimore Orioles Prediction, 5/27/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Baltimore Orioles

Date: Tuesday, May 27, 2025

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: St. Louis (-160) Baltimore (+132)

Oriole Park at Camden Yards is where the Baltimore Orioles (18-34) will attempt to defeat the St. Louis Cardinals (30-23) on Tuesday. The odds on this game have the Cardinals at -160 and the Orioles are sitting at +132. The over/under comes in at 9. The pitchers who are expected to start are Andre Pallante and Tomoyuki Sugano.

As a team, the St. Louis Cardinals are notching 4.8 runs per outing, which puts them at 8th in the league. They have racked up 254 runs while holding a team on-base percentage of .332. The Cardinals have accrued 100 two-baggers as a team and have knocked 48 balls out of the park. They have accounted for 240 RBI's in addition to 470 hits this season, and their team batting average sits at .261. St. Louis has a slugging % of .399 and have struck out 401 times, while drawing a walk on 174 occasions.

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The Cardinals have an earned run average of 3.73 for the season (13th in the league), and they have rung up 373 batters. Cardinals pitchers have given up 40 home runs in addition to 211 runs (12th in the league). They have walked 149 batters and their FIP comes in at 3.66 as a team for the year. St. Louis has allowed 424 base knocks (8.1 per 9 innings) and 195 earned runs. They have a strikeout to walk ratio of 2.50 and their pitching staff sits with a WHIP of 1.22.

Cardinals relief pitchers have entered the game with runners on 48 times in addition to having 66 appearances in high leverage situations. The bullpen have earned 37 holds this season (6th in baseball). The Cardinals relief pitchers have accumulated a save rate of 63.6% and have come into the game in 61 save situations. They have recorded 14 saves on the year and have blown 8 of their 22 chances to save the game. The bullpen pitchers have inherited 66 runners on the campaign with 39.4% of those players crossed the plate. The Cardinals have dispatched 157 relief pitchers to the hill on the season.

The St. Louis Cardinals have a total of 1,412 putouts thus far, in addition to 520 assists and 17 errors. Their fielding percentage sits at .991 which has them ranked 1st in baseball, and they have turned 36 double plays. The Cardinals have turned 71.4% of balls hit into play into outs out of their 4,236 innings on the diamond, which ranks them 8th in the majors.

Pallante has pitched in 353 innings and has accumulated 245 strikeouts in his pro baseball career. His earned run average is 3.85 (151 earned runs allowed) and he has a WHIP of 1.393. He has given up 354 base hits (9.0 hits per nine innings) and has had 138 walks. Pallante (22-17 career win-loss mark) holds a FIP of 3.79 and he has faced 1,505 batters during his time in the majors.

The Baltimore Orioles have accumulated an on-base percentage of .302 and a team batting average of .234 over the course of the season. They have been rung up on 465 occasions (8th in the league) and have earned 407 base knocks. Baltimore has knocked in 58 home runs over the course of the season to go along with 188 RBIs. The Orioles have a team slugging percentage of .386 and they are recording 3.85 runs per contest (25th in MLB). They have hit 75 two-baggers, while getting a free base 151 times as well as scoring 200 runs.

The Baltimore pitching staff have surrendered 295 runs on the campaign while having an ERA of 5.52 (278 earned runs surrendered). They have relinquished 83 HR's and they concede 5.86 runs per 9 innings (29th in the league). The Orioles have a team WHIP of 1.483 with a FIP of 5.05 as a pitching staff so far this year. Their strikeout to walk ratio comes in at 7.80 (392 strikeouts against 182 walks). They rank 28th in baseball as a staff in total hits surrendered with 490.

With 47 save situations, the Orioles have tallied 29 holds and 7 blown saves. Baltimore has called on relief pitchers to step onto the hill in 15 save chances and they have recorded 8 saves. Their relief pitchers have come in 48 times in high leverage situations and on 64 occasions with runners on. Baltimore bullpen pitchers have an inherited score percentage of 25.6% out of their 82 inherited base runners. They sit at 24th in baseball holding a save rate of 53.3%, and they have sent 182 bullpen pitchers onto the field on the campaign.

The Baltimore Orioles have gotten 37 double plays and have earned a fielding percentage of .984 (23rd in the majors). The Orioles have recorded 474 assists, 30 errors and have amassed 1,360 putouts over the course of the season. In their 4,080 innings played, the Orioles have a efficiency on defense of 68.0% (24th in pro baseball).

Sugano (4-3 career record) has a 3.09 earned run average while allowing 7.7 hits per 9 innings. He has a strikeout to walk ratio of 3.20 and he has faced 232 batters in his MLB career. He has surrendered a total of 20 earned runs while earning a WHIP of 1.031 and having a FIP of 3.0. So far in his MLB career, Sugano has surrendered 50 base hits and he has 32 strikeouts in 58 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take St. Louis (-160)

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