St. Louis Cardinals vs Chicago Cubs Prediction, 7/4/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago Cubs

Date: Friday, July 4, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: St. Louis (+172) Chicago (-210)

Wrigley Field is the site where the Chicago Cubs (50-35) will take on the St. Louis Cardinals (47-40) on Friday. The moneyline on this contest has the Cardinals at +172 while the Cubs are at -210. The over/under has been set at 8. The expected starting pitchers will be Miles Mikolas and Colin Rea.

St. Louis is slugging .395 and have been rung up 674 times, while taking a walk on 273 occasions. They have tallied 383 runs batted in in addition to 748 base knocks for the season, while their team batting average is at .253. The Cardinals have accumulated 148 two-baggers as a unit and have knocked 87 balls out of the stadium. They have accounted for 403 runs while holding a team OBP of .324. As a team, the St. Louis Cardinals are putting up 4.6 runs per game, which has them sitting at 9th in the league.

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The Cardinals hold a team ERA of 3.92 this season (16th in the league), and their staff has struck out 631 hitters. Cardinals pitchers have surrendered 73 home runs and also 366 total runs (17th in MLB). Their pitching staff has walked 238 players from the other team and their FIP is 3.70 as a squad this year. St. Louis has given up 733 base knocks (8.5 per 9 innings) in addition to 337 earned runs. Their K/BB ratio is 2.65 and their pitching staff has earned a collective WHIP of 1.26.

Cardinals bullpen pitchers have stepped onto the hill with runners on 85 times and also have had 95 appearances in high leverage situations. The relief pitchers have earned 50 holds this year (13th in baseball). The Cardinals bullpen have earned a save percentage of 63.6% and have entered the game in 86 save situations. They have compiled 21 saves for the year and have blown 12 out of their 33 chances to get a save. The relievers have inherited 112 base runners for the year and 33.0% of those players crossed the plate. The Cardinals have sent 259 relief pitchers to the hill this season.

The Cardinals have turned 70.2% of balls hit into play into outs out of their 6,963 innings, which ranks them 14th in baseball. The St. Louis Cardinals have a total of 2,321 putouts over the course of the season, as well as 844 assists and 32 errors. Their fielding percentage is holding steady at .990 which is 2nd in pro baseball, and have a total of 64 double plays.

Mikolas has pitched in 1,177 innings and has accounted for 851 strikeouts in his career. His ERA is 4.20 (549 earned runs allowed) and he has a career WHIP of 1.210. He has given up 1,195 hits (9.1 hits per 9 innings) and has had 229 free passes. Mikolas (68-69 career record) has a FIP of 4.13 and he has gone up against 4,897 batters in the majors.

The Chicago Cubs have an OBP of .326 in addition to a team batting average of .257 this year. They have struck out on 662 occasions (25th in baseball) and have accounted for 755 hits. Chicago has recorded 125 home runs over the course of the season and 449 runs batted in. The Cubs have a team SLG% of .446 and they tally 5.39 runs per contest (2nd in MLB). They have 150 two-baggers, while walking 293 times and putting up 458 runs.

The Chicago pitching staff have given up 351 runs on the year and come in with a team ERA of 3.85 (324 earned runs given up). They have conceded 100 homers and they relinquish 4.17 runs per 9 innings (14th in the league). The Cubs have a WHIP of 1.242 and are the owners of a FIP of 4.16 as a staff so far this year. Their K/BB ratio sits at 7.60 (637 strikeouts vs 233 walks). They are currently ranked 17th in baseball as a staff in total hits allowed with 709.

Chicago relievers hold an inherited score rate of 32.1% out of their 81 inherited base runners. Their relief pitchers have stepped onto the mound 90 times in high leverage situations and also on 60 occasions with base runners. Sitting with 85 save situations, the Cubs have 53 holds and also 9 blown saves. They sit at 8th in the league with a save percentage of 69.0%, and they have sent 282 relievers to the mound so far this year. Chicago has had relief pitchers enter the contest in 29 save opportunities and they have walked away with 20 saves.

The Chicago Cubs have turned 73 double plays and own a fielding percentage of .988 (6th in professional baseball). The Cubs have racked up 727 assists, 36 errors and have accounted for 2,276 putouts so far this season. Out of their 6,828 innings played, the Cubs are sitting with a defensive efficiency of 70.8% (10th in professional baseball).

Rea (31-23 career record) has earned a 4.55 ERA while allowing 8.9 hits per nine innings. He has a K/BB ratio of 2.69 and he has faced 2,236 opposing batters during his career. He has given up a total of 265 ER's while earning a WHIP of 1.291 and being the owner of a FIP of 4.5. So far in his pro baseball career, Rea has given up 520 base hits and he has 422 punch outs in 524 frames.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-210) and under 8 runs

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