St. Louis Cardinals vs Chicago Cubs Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago Cubs

Date: Friday, September 26, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: St. Louis (+125) Chicago (-145)

The St. Louis Cardinals (78-81) are hitting the road to Wrigley Field on Friday where they will go up against the Chicago Cubs (89-69). The line on this matchup has the Cardinals at +125 and the Cubs are sitting at -145. The total comes in at 8.5. The pitchers expected to start will be Miles Mikolas and Colin Rea.

St. Louis has a slugging percentage of .380 and have been called out on strikes 1,284 times, while taking a walk on 472 occasions. They have 649 runs batted in as well as 1,313 base knocks on the year, and their batting average is sitting at .246. The Cardinals have earned 261 two-baggers as a team and have smacked 146 baseballs out of the park. They have 685 runs while holding a team OBP of .316. As a squad, the St. Louis Cardinals are scoring 4.3 runs per game, which has them sitting at 18th in MLB.

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Their strikeout to walk ratio is 2.62 and their pitching staff holds a collective WHIP of 1.32. Cardinals pitchers have conceded 161 home runs and also 733 runs (22nd in MLB). St. Louis has given up 1,406 hits (9.0 per 9 innings) in addition to 662 earned runs. The Cardinals are sitting with a team ERA of 4.23 for the season (19th in the league), and they have rung up 1,185 hitters. They have walked 453 opposing hitters and their FIP is 4.01 as a team this season.

The Cardinals have dispatched 476 relief pitchers to the mound on the campaign. The relief pitchers have inherited 213 base runners this year and 32.9% of them ended up scoring. They have earned 42 saves on the year and have blown 23 of 65 save opportunities. The Cardinals relief pitchers have a save percentage of 64.6% and have entered the game in 161 save situations. The relief pitchers have 92 holds so far this year (11th in MLB). Cardinals bullpen pitchers have gone to the mound with runners on 153 times as well as having 158 appearances in high leverage situations.

The Cardinals have transformed 68.9% of balls in play into outs in their 12,672 innings, which ranks them 23rd in MLB. The St. Louis Cardinals have accumulated 4,224 putouts over the course of the season, as well as 1,533 assists and 80 errors. Their fielding rate is holding steady at .986 which has them ranked 12th in pro baseball, and they have turned 122 double plays.

Mikolas has taken the ball for 1,247 innings and is sitting with 891 strikeouts so far in his career. Mikolas (72-74 career record) has earned a FIP of 4.17 while he has faced 5,198 batters in the majors. His ERA is 4.23 (586 earned runs allowed) and he has a WHIP of 1.217. He has conceded 1,273 base hits (9.2 hits per nine innings) and has had 245 walks.

The Cubs hold a slugging percentage of .426 and they are scoring 4.85 runs per game (8th in MLB). They have 262 doubles, while taking a walk 544 times and notching 767 runs. Chicago has hit 211 HRs for the season and 745 RBIs. They have struck out on 1,239 occasions (25th in the league) and have 1,336 base hits. The Chicago Cubs have compiled an on-base percentage of .320 as well as a team batting average of .249 so far this season.

The Cubs are sitting with a team WHIP of 1.182 and are the owners of a FIP of 4.20 as a staff this season. Their strikeout to walk ratio comes in at 7.90 (1,221 strikeouts against 397 walks). They sit at 10th in the league as a staff in total hits conceded with 1,256. They have surrendered 198 homers and they relinquish 4.10 runs per 9 innings (7th in the league). The Chicago pitching staff have allowed 637 runs over the course of the season while having an ERA of 3.81 (593 earned runs surrendered).

Chicago bullpen pitchers have an inherited score percentage of 34.1% out of 138 inherited runners. Their relief pitchers have taken the field 157 times in high leverage situations and on 98 occasions with runners on. Sitting with 172 save situations, the Cubs have amassed 106 holds in addition to 20 blown saves. They sit at 4th in MLB with a save percentage of 68.3%, and they have sent 511 bullpen pitchers onto the field this year. Chicago has had relievers enter the game in 63 save chances and they have walked away with 43 saves.

In 12,591 innings on the diamond, the Cubs hold a defensive efficiency of 71.9% (2nd in baseball). The Chicago Cubs have turned 116 double plays and have accounted for a fielding rate of .989 (3rd in professional baseball). The Cubs have accrued 1,314 assists, 60 errors and have earned a total of 4,197 putouts over the course of the season.

During his MLB career, Rea has surrendered 585 hits and he has 486 strikeouts in 599 innings pitched. He has conceded 297 ER's while holding a WHIP of 1.278 and a FIP of 4.4. His K/BB ratio is 2.69 and he has faced 2,546 batters so far in his pro baseball career. Rea (36-27 career mark) is the owner of a 4.46 earned run average and has allowed 8.8 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (-145)

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