St. Louis Cardinals vs Chicago Cubs Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago Cubs

Date: Saturday, September 27, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: St. Louis (+150) Chicago (-182)

The Chicago Cubs (89-69) will try to beat the St. Louis Cardinals (78-81) at Wrigley Field on Saturday. The odds on this game have the Cardinals at +150 while the Cubs are opening at -182. The betting total is set at 9. The expected starting pitchers will be Michael McGreevy and Javier Assad.

As a unit, the St. Louis Cardinals are recording 4.3 runs per contest, which ranks them 18th in MLB. They have 685 runs and hold an on-base percentage of .316. The Cardinals have tallied 261 doubles as a team and have smacked 146 balls out of the stadium. They have 649 RBI's in addition to 1,313 hits for the year, and their team batting average is at .246. St. Louis has a slugging % of .380 and have been called out on strikes 1,284 times, while taking a walk on 472 occasions.

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They have a K/BB ratio of 2.62 and their pitching staff has earned a collective WHIP of 1.32. Cardinals pitchers have given up 161 home runs in addition to 733 runs in total (22nd in baseball). St. Louis has yielded 1,406 base hits (9.0 per 9 innings) as well as 662 earned runs. The Cardinals have compiled a team earned run average of 4.23 for the season (19th in baseball), and their staff has struck out 1,185 batters. Their pitching staff has walked 453 opposing batters and their FIP is 4.01 as a squad this year.

Cardinals relief pitchers have come into the game with opponents on base 153 times in addition to having 158 appearances in high leverage situations. The relievers are sitting with 92 holds on the year (11th in baseball). The Cardinals relievers have a save rate of 64.6% and stepped onto the hill in 161 save situations. They have 42 saves so far this year and have missed out on 23 out of their 65 chances to get a save. The relief pitchers have inherited 213 runners for the season with 32.9% of those players crossed the plate. The Cardinals have sent 476 relievers to the hill so far this year.

The St. Louis Cardinals have earned 4,224 putouts over the course of the season, as well as 1,533 assists and 80 errors. Their fielding rate is holding steady at .986 which puts them in 12th in professional baseball, and they have turned 122 double plays. The Cardinals have converted 68.9% of balls in play into outs out of their 12,672 innings on the diamond, which has them ranked 23rd in professional baseball.

McGreevy has taken the ball for 114 innings and is sitting with 73 strikeouts in his career. McGreevy (11-3 career record) holds a FIP of 3.81 while he has gone up against 465 batters in the major leagues. His earned run average is 3.87 (49 ER's allowed) and he has a career WHIP of 1.140. He has surrendered 110 hits (8.7 hits per nine innings) and has had 20 walks.

The Chicago Cubs have tallied an on-base percentage of .320 in addition to a team batting average of .249 on the season. They have struck out on 1,239 occasions (25th in the league) and have 1,336 base hits. Chicago has accumulated 211 home runs this year and 745 runs batted in. The Cubs hold a team slugging % of .426 and they earn 4.85 runs per contest (8th in the league). They have notched 262 doubles, while walking 544 times as well as scoring 767 runs.

The Cubs hold a team WHIP of 1.182 in addition to having a FIP of 4.20 as a team on the year. Their K/BB ratio sits at 7.90 (1,221 strikeouts against 397 walks). They come in at 10th in the league as a staff in total hits relinquished with 1,256. They have allowed 198 homers and they surrender 4.10 runs per 9 innings (7th in MLB). The Chicago pitching staff have conceded 637 runs over the course of the season while holding an ERA of 3.81 (593 earned runs given up).

Chicago has called on relief pitchers to step onto the hill in 63 save chances and they have tallied 43 saves. They sit at 4th in baseball holding a save rate of 68.3%, and they have dispatched 511 relievers onto the field so far this season. Their relief pitchers have come in 157 times in high leverage situations and on 98 occasions with runners on. Chicago bullpen pitchers hold an inherited score percentage of 34.1% out of their 138 inherited base runners. With 172 save situations, the Cubs have accrued 106 holds in addition to 20 blown saves.

The Chicago Cubs have turned 116 double plays and own a fielding percentage of .989 (3rd in baseball). The Cubs have racked up 1,314 assists, 60 errors and have earned a total of 4,197 putouts this season. In 12,591 innings on the diamond, the Cubs have earned a defensive efficiency of 71.9% (2nd in professional baseball).

During his MLB career, Assad has allowed 301 base hits while he has tallied 265 K's in 325 innings pitched. Assad (17-12 win-loss mark in his career) is the owner of a 3.49 ERA and has conceded 8.3 hits per nine innings. He has given up 126 ER's while holding a WHIP of 1.341 and a FIP of 3.4. He has a K/BB ratio of 1.96 and he has gone up against 1,387 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (-182)

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