St. Louis Cardinals vs Chicago White Sox Prediction, 6/18/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Chicago White Sox

Date: Wednesday, June 18, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: St. Louis (-145) Chicago (+125)

The Chicago White Sox (23-49) host the St. Louis Cardinals (37-35) at Rate Field on Wednesday. The line on this matchup has the Cardinals at -145 and the White Sox open at +125. The total has been set at 8.5. The pitchers who are expected to start will be Sonny Gray and Sean Burke.

The Cardinals have tallied 125 doubles as a team and have hit 66 balls out of the stadium. St. Louis is slugging .391 and have been called out on strikes 562 times, while drawing a walk on 228 occasions. As a squad, the St. Louis Cardinals are recording 4.6 runs per contest, which puts them at 11th in baseball. They have 312 runs batted in and 624 base knocks this year, while their team batting average comes in at .255. They have notched a total of 328 runs scored while holding a team on-base percentage of .326.

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Their strikeout to walk ratio is 2.66 and their pitching staff has a team WHIP of 1.28. Cardinals pitchers have relinquished 59 long balls and 310 total runs (19th in MLB). St. Louis has relinquished 623 base hits (8.8 per 9 innings) and 283 earned runs. The Cardinals hold a team earned run average of 3.99 for the year (20th in the league), and the staff has struck out 516 batters. They have walked 194 opposing players and their FIP is 3.68 as a unit this year.

The Cardinals relievers have a save rate of 60.7% and stepped onto the hill in 75 save situations. The relief pitchers have inherited 94 base runners this season and 36.2% of them crossed home plate. Cardinals bullpen pitchers have gone to the mound with opponents on base 72 times and also have had 82 appearances in high leverage situations. The Cardinals have dispatched 215 relievers to the mound over the course of the season. The bullpen are sitting with 44 holds this year (15th in the league). They have accumulated 17 saves for the year and have not converted 11 of their 28 save chances.

The St. Louis Cardinals have 1,913 putouts thus far, as well as 697 assists and 27 errors. Their fielding percentage is holding at .990 which has them sitting 2nd in the majors, and have a total of 53 double plays. The Cardinals have turned 69.5% of baseballs in play into outs out of 5,739 innings, which has them sitting 18th in professional baseball.

Gray has taken the hill for 1,816 innings and has totaled 1,809 punch outs during his career. Gray (118-96 career win-loss mark) holds a FIP of 3.47 while facing 7,525 opposing batters in the major leagues. His ERA is 3.52 (711 ER's allowed) and he has a WHIP of 1.193. He has conceded 1,569 base knocks (7.8 hits per nine innings) and has had 598 walks.

The White Sox have a team slugging % of .343 and they have an average of 3.44 runs per outing (27th in MLB). They have recorded 111 doubles, while taking a walk 235 times and putting up 248 runs. Chicago has a total of 55 home runs for the year as well as 238 runs batted in. They have been called out on strikes on 628 occasions (9th in MLB) and have notched a total of 523 base hits. The Chicago White Sox have a team on-base percentage of .295 in addition to a batting average of .222 for the year.

The White Sox hold a team WHIP of 1.398 and have a FIP of 4.45 as a unit so far this year. They come in at 19th in baseball as a staff in total hits relinquished with 603. The Chicago pitching staff have surrendered 310 runs for the year and come in with a team ERA of 4.13 (285 earned runs allowed). They have earned a strikeout to walk ratio of 7.50 (521 strikeouts against 265 walks). They have yielded 75 HR's and they allow 4.49 runs per 9 innings (22nd in baseball).

Chicago relief pitchers have an inherited score rate of 28.6% out of their 98 inherited runners. Their relief pitchers have stepped onto the hill 66 times in high leverage situations in addition to 69 occasions with runners on base. Sitting with 54 save situations, the White Sox have 35 holds and 12 blown saves. They are ranked 30th in the league holding a save rate of 36.8%, and they have dispatched 229 relievers to the mound on the campaign. Chicago has had bullpen pitchers step onto the hill in 19 save chances and they have converted 7 saves.

The Chicago White Sox have turned 60 double plays and have a fielding percentage of .982 (26th in the majors). The White Sox have accrued 583 assists, 44 errors and have earned 1,864 putouts on the season. In 5,592 innings played, the White Sox have a efficiency on defense of 69.3% (20th in baseball).

Burke (5-7 mark in his career) has a 4.04 earned run average and has conceded 8.2 hits per 9 innings. He has a K/BB ratio of 1.90 and he has faced 387 opposing batters in his career. He has conceded a total of 40 ER's while holding a WHIP of 1.357 and a FIP of 4.0. So far in his career, Burke has surrendered 81 hits while accumulating 76 strikeouts in 89 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+125)

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