St. Louis Cardinals vs Cincinnati Reds Prediction, 8/29/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Cincinnati Reds

Date: Friday, August 29, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: St. Louis (+120) Cincinnati (-144)

Great American Ball Park is the site where the Cincinnati Reds (68-66) will meet the St. Louis Cardinals (65-69) on Friday. The odds on this game have St. Louis at +120 and Cincinnati is sitting at -144. The over/under has been set at 8.5. The pitchers expected to start will be Matthew Liberatore and Zack Littell.

The Cardinals have accrued 220 two-baggers as a unit and have hit 126 baseballs out of the park. St. Louis has a slugging rate of .383 and have been rung up 1,059 times, while being walked on 405 occasions. As a team, the St. Louis Cardinals are scoring 4.4 runs per outing, which ranks them 16th in the league. They have 556 RBI's and 1,116 hits so far this season, while their team batting average is sitting at .248. They have earned a total of 584 runs while having a team OBP of .317.

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Their K/BB ratio is 2.68 and their pitching staff holds a WHIP of 1.31. Cardinals pitchers have surrendered 135 home runs and 621 runs (23rd in baseball). St. Louis has allowed 1,173 base hits (8.9 per 9 innings) in addition to 566 earned runs. The Cardinals are sitting with a team ERA of 4.31 this year (21st in MLB), and the staff has rung up 990 hitters. They have walked 370 hitters and their FIP sits at 3.97 as a unit so far this year.

Cardinals relief pitchers have gone to the mound with runners on base 126 times in addition to having 123 appearances in high leverage situations. The bullpen have earned 74 holds this year (14th in MLB). The Cardinals relief pitchers have earned a save rate of 64.0% and have entered the game in 127 save situations. They have recorded 32 saves this season and have blown 18 of 50 save opportunities. The relievers have inherited 176 base runners this season and 33.5% of those players crossed home plate. The Cardinals have sent 395 relievers to the mound on the year.

The Cardinals have converted 69.1% of balls hit into play into outs out of their 10,644 innings on the diamond, which has them ranked 23rd in professional baseball. The St. Louis Cardinals have earned a total of 3,548 putouts so far this season, in addition to 1,287 assists and 66 errors. Their fielding percentage is at .987 which has them sitting 15th in baseball, and they have turned 103 double plays.

Liberatore has thrown 308 frames and is sitting with 248 punch outs during his pro baseball career. His ERA is 4.70 (161 ER's allowed) and he has a career WHIP of 1.372. He has given up 320 hits (9.3 hits per nine innings) with 103 free passes. Liberatore (14-23 career record) is the owner of a FIP of 4.63 while he has faced 1,333 batters in the major leagues.

The Reds have a slugging percentage of .388 and they are earning 4.46 runs per game (15th in MLB). They have 212 doubles, while walking 435 times as well as putting up 597 runs. Cincinnati has compiled 130 home runs on the campaign as well as 562 RBIs. They have been rung up on 1,165 occasions (7th in MLB) and are sitting with 1,107 hits. The Cincinnati Reds have a team on-base percentage of .316 as well as a team batting average of .246 for the year.

The Cincinnati pitching staff have surrendered 563 runs over the course of the season while holding a team ERA of 3.85 (506 earned runs yielded). They have surrendered 150 home runs and they relinquish 4.28 runs per 9 innings (14th in the league). The Reds hold a team WHIP of 1.240 and have a FIP of 4.05 as a staff on the year. Their K/BB ratio is 8.50 (1,125 strikeouts vs 418 walks). They rank 7th in the league as a staff in total hits conceded with 1,050.

Cincinnati has had bullpen pitchers step onto the mound in 50 save chances and they have come away with 31 saves. They sit at 19th in baseball holding a save rate of 62.0%, and they have dispatched 457 relievers to the hill for the season. Their relievers have stepped onto the mound 135 times in high leverage situations and on 123 occasions with runners on base. Cincinnati relievers have an inherited score rate of 32.1% out of their 184 inherited runners. Sitting with 135 save situations, the Reds have earned 83 holds in addition to 19 blown saves.

The Cincinnati Reds have turned 85 double plays and own a fielding percentage of .984 (26th in pro baseball). The Reds have racked up 1,024 assists, 76 errors and have notched a total of 3,554 putouts on the season. Out of their 10,662 innings on the field, the Reds have accumulated a defensive efficiency of 70.8% (8th in the majors).

In his pro baseball career, Littell has allowed 571 base knocks while he has tallied 472 K's in 570 innings. He has given up 243 earned runs while holding a WHIP of 1.230 and having a FIP of 3.8. He has a K/BB ratio of 3.63 and he has faced 2,383 opposing batters so far in his MLB career. Littell (33-29 win-loss record in his career) has a 3.84 earned run average and has surrendered 9.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+120)

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