St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/12/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Friday, September 12, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: St. Louis (+125) Milwaukee (-150)

The Milwaukee Brewers (89-58) will compete against the St. Louis Cardinals (72-75) at American Family Field on Friday. The odds on this game have the Cardinals at +125 while the Brewers are priced at -150. The over/under has been set at 9. The starting pitchers are Andre Pallante and Quinn Priester.

As a unit, the St. Louis Cardinals are scoring 4.3 runs/g, which puts them at 22nd in baseball. They have accumulated 629 runs while having a team on-base percentage of .313. The Cardinals have accounted for 234 doubles as a team and have hit 138 baseballs out of the park. They have tallied 599 runs batted in and 1,206 base knocks so far this year, while their team batting average is sitting at .244. St. Louis has a slugging % of .379 and have been called out on strikes 1,185 times, while drawing a walk on 433 occasions.

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The Cardinals have a team ERA of 4.26 on the year (21st in MLB), and their staff has rung up 1,086 hitters. Cardinals pitchers have conceded 151 home runs and also 675 total runs (22nd in baseball). They have walked 415 opposing batters and their FIP sits at 4.04 as a squad for the season. St. Louis has surrendered 1,293 hits (9.0 per 9 innings) in addition to 615 earned runs. They have earned a strikeout to walk ratio of 2.62 and their pitching staff sits with a WHIP of 1.31.

The Cardinals relievers have earned a save percentage of 65.5% and stepped onto the hill in 143 save situations. The relief pitchers have inherited 195 runners this season and 32.8% of those runners earned a run for their team. Cardinals pitchers have entered the game with runners on base 141 times and also have had 140 appearances in high leverage situations. The Cardinals have dispatched 434 relievers to the hill on the campaign. The relief pitchers have racked up 82 holds on the year (14th in the league). They have recorded 38 saves so far this season and have not converted 20 of their 58 save chances.

The Cardinals have converted 69.1% of balls in play into outs out of 11,706 innings on the field, ranking them 21st in pro baseball. The St. Louis Cardinals have amassed 3,902 putouts so far this season, as well as 1,414 assists and 71 errors. Their fielding percentage is holding steady at .987 which ranks 11th in pro baseball, and they have turned 116 double plays.

Pallante (24-27 career win-loss record) has a FIP of 4.22 while he has gone up against 1,923 batters during his time in the majors. He has surrendered 460 hits (9.3 hits per 9 innings) and has 171 walks. His earned run average is 4.29 (213 earned runs allowed) and he has a WHIP of 1.411. Pallante has taken the mound for 447 frames and has accumulated 314 punch outs in his MLB career.

Milwaukee has tallied 157 long balls for the season as well as 689 runs batted in. They have 239 two-baggers, while walking 504 times as well as racking up 743 runs. The Milwaukee Brewers have recorded an on-base percentage of .333 in addition to a team batting average of .260 this year. The Brewers hold a slugging percentage of .408 and they are scoring 5.05 runs per contest (3rd in MLB). They have been called out on strikes on 1,147 occasions (25th in baseball) and are sitting with 1,300 base hits.

The Brewers have a team WHIP of 1.232 and have a FIP of 3.92 as a unit for the year. They are currently ranked 3rd in the league as a pitching staff in total hits conceded with 1,124. The Milwaukee pitching staff have surrendered 576 runs so far this year and come in with a team ERA of 3.63 (527 earned runs conceded). Their strikeout to walk ratio comes in at 8.90 (1,290 strikeouts vs 485 free passes). They have yielded 152 dingers and they relinquish 3.97 runs per 9 innings (4th in MLB).

With 165 save situations, the Brewers have accumulated 100 holds in addition to 19 blown saves. Milwaukee has called on bullpen pitchers to take the mound in 61 save chances and they have tallied 42 saves. Their relievers have stepped onto the hill 169 times in high leverage situations and on 129 occasions with base runners. Milwaukee relief pitchers have an inherited score percentage of 29.7% out of 192 inherited base runners. They rank 6th in baseball with a save percentage of 68.9%, and they have sent 494 relief pitchers onto the field on the year.

The Milwaukee Brewers have gotten 107 double plays and hold a fielding percentage of .987 (9th in professional baseball). The Brewers have 1,172 assists, 65 errors and have a total of 3,920 putouts during this campaign. Out of their 11,760 innings on the diamond, the Brewers hold a efficiency on defense of 70.9% (4th in MLB).

So far in his pro baseball career, Priester has allowed 242 base hits while totaling 182 strikeouts in 240 innings. Priester (18-11 win-loss record in his career) has earned a 4.49 earned run average and has allowed 9.1 hits per 9 innings. He has given up a total of 120 ER's while holding a WHIP of 1.369 and a FIP of 4.4. His K/BB ratio is 2.09 and he has faced 1,041 batters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Milwaukee (-150) and under 9 runs

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