St. Louis Cardinals vs Milwaukee Brewers Prediction, 9/13/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs Milwaukee Brewers

Date: Saturday, September 13, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: St. Louis (+220) Milwaukee (-275)

The Milwaukee Brewers (89-58) will play the St. Louis Cardinals (72-75) at American Family Field on Saturday. The odds on this game have St. Louis at +220 while Milwaukee is at -275. The over/under is set at 8.5. The pitchers taking the mound are Sonny Gray and Brandon Woodruff.

As a team, the St. Louis Cardinals are compiling 4.3 runs per outing, which is 22nd in the league. They have accounted for 629 runs scored and hold an OBP of .313. The Cardinals have hit 234 doubles as a squad and have hit 138 balls out of the park. They have tallied 599 runs batted in in addition to 1,206 hits on the year, while their batting average is sitting at .244. St. Louis is slugging .379 and have struck out 1,185 times, while drawing a walk on 433 occasions.

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The Cardinals have compiled a team earned run average of 4.26 on the season (21st in the league), and they have rung up 1,086 batters. Cardinals pitchers have allowed 151 home runs and also 675 total runs (22nd in the league). Their pitching staff has walked 415 players from the other team and their FIP sits at 4.04 as a unit for the season. St. Louis has given up 1,293 base hits (9.0 per 9 innings) and 615 earned runs. Their strikeout to walk ratio sits at 2.62 and their pitching staff has recorded a WHIP of 1.31.

The Cardinals relievers have a save percentage of 65.5% and stepped onto the hill in 143 save situations. The relief pitchers have inherited 195 base runners on the year with 32.8% of those runners ended up scoring. Cardinals relief pitchers have entered the contest with runners on base 141 times in addition to having 140 appearances in high leverage situations. The Cardinals have sent 434 relievers to the hill on the season. The relief pitchers are sitting with 82 holds so far this season (14th in the league). They have compiled 38 saves for the year and have blown 20 of 58 save opportunities.

The Cardinals have turned 69.1% of balls hit into play into outs in their 11,706 innings, which has them sitting 21st in MLB. The St. Louis Cardinals have 3,902 putouts on the year, in addition to 1,414 assists and 71 errors. Their fielding percentage sits at .987 which is 11th in baseball, and they have turned 116 double plays.

Gray has thrown 1,900 innings and has accumulated 1,903 strikeouts during his pro baseball career. His earned run average is 3.59 (758 ER's allowed) and his WHIP is 1.196. He has given up 1,655 base hits (7.8 hits per 9 innings) and has had 618 walks. Gray (124-102 career mark) is the owner of a FIP of 3.54 and he has faced 7,878 opposing batters in the major leagues.

The Milwaukee Brewers are sitting with an on-base percentage of .333 in addition to a batting average of .260 on the season. They have struck out on 1,147 occasions (25th in MLB) and have earned 1,300 base hits. Milwaukee has 157 home runs this season as well as 689 runs batted in. The Brewers hold a slugging % of .408 and they have an average of 5.05 runs per game (3rd in MLB). They have hit 239 doubles, while walking 504 times and putting up 743 runs.

The Brewers are sitting with a team WHIP of 1.232 with a FIP of 3.92 as a pitching staff so far this season. Their K/BB ratio sits at 8.90 (1,290 strikeouts vs 485 bases on balls). They sit at 3rd in the league as a pitching staff in total hits conceded with 1,124. They have allowed 152 long balls and they surrender 3.97 runs per 9 innings (4th in MLB). The Milwaukee pitching staff have conceded 576 runs on the year while holding a team ERA of 3.63 (527 earned runs given up).

Milwaukee relievers hold an inherited score rate of 29.7% out of 192 inherited base runners. Their relief pitchers have stepped onto the mound 169 times in high leverage situations and on 129 occasions with runners on. With 165 save situations, the Brewers have accrued 100 holds in addition to 19 blown saves. They sit at 6th in baseball holding a save percentage of 68.9%, and they have dispatched 494 bullpen pitchers to the hill so far this season. Milwaukee has had relievers step onto the hill in 61 save opportunities and they have earned 42 saves.

The Milwaukee Brewers have turned 107 double plays and hold a fielding percentage of .987 (9th in the majors). The Brewers have racked up 1,172 assists, 65 errors and have accumulated 3,920 putouts for the year. In 11,760 innings on the diamond, the Brewers hold a defensive efficiency of 70.9% (4th in pro baseball).

Thus far in his career, Woodruff has conceded 578 hits and he has 862 punch outs in 739 innings pitched. He has conceded a total of 256 ER's while earning a WHIP of 1.039 and being the owner of a FIP of 3.1. He has a K/BB ratio of 4.54 and he has faced 2,966 hitters so far in his pro baseball career. Woodruff (52-28 career mark) is the owner of a 3.12 ERA and has conceded 7.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Milwaukee (-275) and under 8.5 runs

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